PDB entry 2b7h

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HEADER    OXYGEN STORAGE/TRANSPORT                04-OCT-05   2B7H              
TITLE     HEMOGLOBIN FROM CERDOCYON THOUS, A CANIDAE FROM BRAZIL, AT            
TITLE    2 2.2 ANGSTROMS RESOLUTION                                             
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: HEMOGLOBIN ALPHA CHAIN;                                    
COMPND   3 CHAIN: A, C;                                                         
COMPND   4 MOL_ID: 2;                                                           
COMPND   5 MOLECULE: HEMOGLOBIN BETA CHAIN;                                     
COMPND   6 CHAIN: B, D                                                          
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: DUSICYON THOUS;                                 
SOURCE   3 MOL_ID: 2;                                                           
SOURCE   4 ORGANISM_SCIENTIFIC: DUSICYON THOUS                                  
KEYWDS    HEMOGLOBIN, AQUOMET, X-RAY CRYSTALLOGRAPHY, CERDOCYON THOUS           
EXPDTA    X-RAY DIFFRACTION                                                     
AUTHOR    G.F.ESTEVES,V.C.SILVA,C.BLOCH JR.,F.J.MEDRANO,                        
AUTHOR   2 J.A.R.G.BARBOSA,S.M.FREITAS                                          
REVDAT   1   12-SEP-06 2B7H    0                                                
JRNL        AUTH   G.F.ESTEVES,V.C.SILVA,C.BLOCH JR.,F.J.MEDRANO,               
JRNL        AUTH 2 J.A.R.G.BARBOSA,S.M.FREITAS                                  
JRNL        TITL   CRYSTAL STRUCTURE AND BIOPHYSICAL CHARACTERIZATION           
JRNL        TITL 2 OF THE CERDOCYON THOUS, A CANIDAE FROM BRAZIL.               
JRNL        REF    TO BE PUBLISHED                                              
JRNL        REFN                                                                
REMARK   1                                                                      
REMARK   2                                                                      
REMARK   2 RESOLUTION. 2.20 ANGSTROMS.                                          
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   PROGRAM     : REFMAC 5.2.0005                                      
REMARK   3   AUTHORS     : MURSHUDOV,VAGIN,DODSON                               
REMARK   3                                                                      
REMARK   3    REFINEMENT TARGET : ENGH & HUBER                                  
REMARK   3                                                                      
REMARK   3  DATA USED IN REFINEMENT.                                            
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.20                           
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 30.00                          
REMARK   3   DATA CUTOFF            (SIGMA(F)) : 0.000                          
REMARK   3   COMPLETENESS FOR RANGE        (%) : 99.9                           
REMARK   3   NUMBER OF REFLECTIONS             : 28633                          
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT.                                     
REMARK   3   CROSS-VALIDATION METHOD          : THROUGHOUT                      
REMARK   3   FREE R VALUE TEST SET SELECTION  : RANDOM                          
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.169                           
REMARK   3   R VALUE            (WORKING SET) : 0.165                           
REMARK   3   FREE R VALUE                     : 0.233                           
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 5.100                           
REMARK   3   FREE R VALUE TEST SET COUNT      : 1530                            
REMARK   3                                                                      
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.                                  
REMARK   3   TOTAL NUMBER OF BINS USED           : 20                           
REMARK   3   BIN RESOLUTION RANGE HIGH           : 2.20                         
REMARK   3   BIN RESOLUTION RANGE LOW            : 2.26                         
REMARK   3   REFLECTION IN BIN     (WORKING SET) : 2039                         
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : 99.26                        
REMARK   3   BIN R VALUE           (WORKING SET) : 0.1680                       
REMARK   3   BIN FREE R VALUE SET COUNT          : 108                          
REMARK   3   BIN FREE R VALUE                    : 0.2740                       
REMARK   3                                                                      
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.                    
REMARK   3   ALL ATOMS                : 5037                                    
REMARK   3                                                                      
REMARK   3  B VALUES.                                                           
REMARK   3   FROM WILSON PLOT           (A**2) : 26.91                          
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 27.57                          
REMARK   3   OVERALL ANISOTROPIC B VALUE.                                       
REMARK   3    B11 (A**2) : -1.00000                                             
REMARK   3    B22 (A**2) : -0.15000                                             
REMARK   3    B33 (A**2) : 1.15000                                              
REMARK   3    B12 (A**2) : 0.00000                                              
REMARK   3    B13 (A**2) : 0.00000                                              
REMARK   3    B23 (A**2) : 0.00000                                              
REMARK   3                                                                      
REMARK   3  ESTIMATED OVERALL COORDINATE ERROR.                                 
REMARK   3   ESU BASED ON R VALUE                            (A): 0.283         
REMARK   3   ESU BASED ON FREE R VALUE                       (A): 0.218         
REMARK   3   ESU BASED ON MAXIMUM LIKELIHOOD                 (A): 0.142         
REMARK   3   ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2): 10.249        
REMARK   3                                                                      
REMARK   3 CORRELATION COEFFICIENTS.                                            
REMARK   3   CORRELATION COEFFICIENT FO-FC      : 0.953                         
REMARK   3   CORRELATION COEFFICIENT FO-FC FREE : 0.911                         
REMARK   3                                                                      
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES        COUNT    RMS    WEIGHT      
REMARK   3   BOND LENGTHS REFINED ATOMS        (A):  4716 ; 0.015 ; 0.022       
REMARK   3   BOND LENGTHS OTHERS               (A):  NULL ;  NULL ;  NULL       
REMARK   3   BOND ANGLES REFINED ATOMS   (DEGREES):  6468 ; 1.399 ; 2.065       
REMARK   3   BOND ANGLES OTHERS          (DEGREES):  NULL ;  NULL ;  NULL       
REMARK   3   TORSION ANGLES, PERIOD 1    (DEGREES):   571 ; 5.525 ; 5.000       
REMARK   3   TORSION ANGLES, PERIOD 2    (DEGREES):   182 ;36.130 ;24.341       
REMARK   3   TORSION ANGLES, PERIOD 3    (DEGREES):   729 ;14.431 ;15.000       
REMARK   3   TORSION ANGLES, PERIOD 4    (DEGREES):    10 ;12.223 ;15.000       
REMARK   3   CHIRAL-CENTER RESTRAINTS       (A**3):   705 ; 0.092 ; 0.200       
REMARK   3   GENERAL PLANES REFINED ATOMS      (A):  3548 ; 0.006 ; 0.020       
REMARK   3   GENERAL PLANES OTHERS             (A):  NULL ;  NULL ;  NULL       
REMARK   3   NON-BONDED CONTACTS REFINED ATOMS (A):  3065 ; 0.216 ; 0.200       
REMARK   3   NON-BONDED CONTACTS OTHERS        (A):  NULL ;  NULL ;  NULL       
REMARK   3   NON-BONDED TORSION REFINED ATOMS  (A):  3314 ; 0.312 ; 0.200       
REMARK   3   NON-BONDED TORSION OTHERS         (A):  NULL ;  NULL ;  NULL       
REMARK   3   H-BOND (X...Y) REFINED ATOMS      (A):   588 ; 0.161 ; 0.200       
REMARK   3   H-BOND (X...Y) OTHERS             (A):  NULL ;  NULL ;  NULL       
REMARK   3   POTENTIAL METAL-ION REFINED ATOMS (A):     2 ; 0.025 ; 0.200       
REMARK   3   POTENTIAL METAL-ION OTHERS        (A):  NULL ;  NULL ;  NULL       
REMARK   3   SYMMETRY VDW REFINED ATOMS        (A):    58 ; 0.151 ; 0.200       
REMARK   3   SYMMETRY VDW OTHERS               (A):  NULL ;  NULL ;  NULL       
REMARK   3   SYMMETRY H-BOND REFINED ATOMS     (A):    15 ; 0.156 ; 0.200       
REMARK   3   SYMMETRY H-BOND OTHERS            (A):  NULL ;  NULL ;  NULL       
REMARK   3   SYMMETRY METAL-ION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL       
REMARK   3   SYMMETRY METAL-ION OTHERS         (A):  NULL ;  NULL ;  NULL       
REMARK   3                                                                      
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.     COUNT   RMS    WEIGHT      
REMARK   3   MAIN-CHAIN BOND REFINED ATOMS  (A**2):  2886 ; 0.707 ; 1.500       
REMARK   3   MAIN-CHAIN BOND OTHER ATOMS    (A**2):  NULL ;  NULL ;  NULL       
REMARK   3   MAIN-CHAIN ANGLE REFINED ATOMS (A**2):  4576 ; 1.196 ; 2.000       
REMARK   3   SIDE-CHAIN BOND REFINED ATOMS  (A**2):  2061 ; 2.048 ; 3.000       
REMARK   3   SIDE-CHAIN ANGLE REFINED ATOMS (A**2):  1884 ; 2.996 ; 4.500       
REMARK   3                                                                      
REMARK   3 ANISOTROPIC THERMAL FACTOR RESTRAINTS.    COUNT   RMS   WEIGHT       
REMARK   3   RIGID-BOND RESTRAINTS          (A**2):  NULL ;  NULL ;  NULL       
REMARK   3   SPHERICITY; FREE ATOMS         (A**2):  NULL ;  NULL ;  NULL       
REMARK   3   SPHERICITY; BONDED ATOMS       (A**2):  NULL ;  NULL ;  NULL       
REMARK   3                                                                      
REMARK   3  NCS RESTRAINTS STATISTICS                                           
REMARK   3   NUMBER OF DIFFERENT NCS GROUPS : 0                                 
REMARK   3                                                                      
REMARK   3  TLS DETAILS                                                         
REMARK   3   NUMBER OF TLS GROUPS  : 4                                          
REMARK   3                                                                      
REMARK   3   TLS GROUP : 1                                                      
REMARK   3    NUMBER OF COMPONENTS GROUP : 2                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   A     1        A   141                          
REMARK   3    RESIDUE RANGE :   A   200        A   200                          
REMARK   3    ORIGIN FOR THE GROUP (A): -14.7250  -6.8243  -4.3671              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:  -0.0976 T22:  -0.1415                                     
REMARK   3      T33:  -0.1875 T12:   0.0092                                     
REMARK   3      T13:   0.0074 T23:   0.0019                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   3.0878 L22:   1.2604                                     
REMARK   3      L33:   1.4903 L12:   0.0346                                     
REMARK   3      L13:   0.0893 L23:   0.2159                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0242 S12:   0.0197 S13:  -0.0627                       
REMARK   3      S21:   0.0231 S22:   0.0349 S23:   0.0420                       
REMARK   3      S31:   0.1783 S32:   0.1128 S33:  -0.0107                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 2                                                      
REMARK   3    NUMBER OF COMPONENTS GROUP : 2                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   B     2        B   145                          
REMARK   3    RESIDUE RANGE :   B   200        B   200                          
REMARK   3    ORIGIN FOR THE GROUP (A): -31.6549   9.3321  -0.0934              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:  -0.0672 T22:  -0.1102                                     
REMARK   3      T33:  -0.0144 T12:   0.0291                                     
REMARK   3      T13:  -0.0393 T23:   0.0067                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   4.0680 L22:   1.8756                                     
REMARK   3      L33:   2.2526 L12:  -0.2974                                     
REMARK   3      L13:  -1.2965 L23:  -0.1522                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0621 S12:  -0.0077 S13:   0.6078                       
REMARK   3      S21:   0.1159 S22:   0.0630 S23:  -0.0500                       
REMARK   3      S31:  -0.3672 S32:  -0.2119 S33:  -0.1251                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 3                                                      
REMARK   3    NUMBER OF COMPONENTS GROUP : 2                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   C     1        C   141                          
REMARK   3    RESIDUE RANGE :   C   200        C   200                          
REMARK   3    ORIGIN FOR THE GROUP (A): -27.9532 -11.6629  23.8805              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:  -0.1076 T22:  -0.1571                                     
REMARK   3      T33:  -0.1444 T12:  -0.0177                                     
REMARK   3      T13:   0.0376 T23:   0.0152                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   3.3970 L22:   1.7903                                     
REMARK   3      L33:   1.5880 L12:   0.3197                                     
REMARK   3      L13:   0.4970 L23:   0.4025                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0199 S12:  -0.0320 S13:  -0.2864                       
REMARK   3      S21:  -0.1146 S22:  -0.0218 S23:  -0.1375                       
REMARK   3      S31:   0.1674 S32:  -0.0991 S33:   0.0417                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 4                                                      
REMARK   3    NUMBER OF COMPONENTS GROUP : 2                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   D     1        D   145                          
REMARK   3    RESIDUE RANGE :   D   200        D   200                          
REMARK   3    ORIGIN FOR THE GROUP (A): -11.2152   5.1936  25.1298              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:  -0.1160 T22:  -0.1212                                     
REMARK   3      T33:  -0.1331 T12:  -0.0116                                     
REMARK   3      T13:  -0.0279 T23:  -0.0061                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.7702 L22:   1.9285                                     
REMARK   3      L33:   2.5942 L12:   0.1424                                     
REMARK   3      L13:  -1.1426 L23:   0.8494                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0295 S12:   0.0123 S13:   0.2906                       
REMARK   3      S21:  -0.1109 S22:   0.0139 S23:  -0.0652                       
REMARK   3      S31:  -0.2953 S32:   0.1211 S33:  -0.0433                       
REMARK   3                                                                      
REMARK   3  BULK SOLVENT MODELLING.                                             
REMARK   3   METHOD USED : BABINET MODEL WITH MASK                              
REMARK   3   PARAMETERS FOR MASK CALCULATION                                    
REMARK   3   VDW PROBE RADIUS   : 1.20                                          
REMARK   3   ION PROBE RADIUS   : 0.80                                          
REMARK   3   SHRINKAGE RADIUS   : 0.80                                          
REMARK   3                                                                      
REMARK   3  OTHER REFINEMENT REMARKS: SIMULATED ANNEALING WAS PERFORMED         
REMARK   3  WITH THE CNS SOFTWARE IN THE FIRST CYCLE OR REFINEMENT. USED        
REMARK   3  TLS REFINEMENT. TYR 145 FROM THE B AND D MOLECULES PRESENTED        
REMARK   3  WEAK DENSITY FOR AN ALTERNATE CONFORMATION THAT WAS NOT             
REMARK   3  MODELED.                                                            
REMARK   4                                                                      
REMARK   4 2B7H COMPLIES WITH FORMAT V. 3.0, 1-DEC-2006                         
REMARK   4                                                                      
REMARK   4 THIS IS THE REMEDIATED VERSION OF THIS PDB ENTRY.                    
REMARK   4 REMEDIATED DATA FILE REVISION 3.100 (2007-03-17)                     
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB.                               
REMARK 100 THE RCSB ID CODE IS RCSB034770.                                      
REMARK 200                                                                      
REMARK 200 EXPERIMENTAL DETAILS                                                 
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION                  
REMARK 200  DATE OF DATA COLLECTION        : 19-MAR-2004                        
REMARK 200  TEMPERATURE           (KELVIN) : 100.0                              
REMARK 200  PH                             : 7.80                               
REMARK 200  NUMBER OF CRYSTALS USED        : 1                                  
REMARK 200                                                                      
REMARK 200  SYNCHROTRON              (Y/N) : Y                                  
REMARK 200  RADIATION SOURCE               : LNLS                               
REMARK 200  BEAMLINE                       : D03B-MX1                           
REMARK 200  X-RAY GENERATOR MODEL          : NULL                               
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M                                  
REMARK 200  WAVELENGTH OR RANGE        (A) : 1.4270                             
REMARK 200  MONOCHROMATOR                  : SI CRYSTAL                         
REMARK 200  OPTICS                         : NULL                               
REMARK 200                                                                      
REMARK 200  DETECTOR TYPE                  : CCD                                
REMARK 200  DETECTOR MANUFACTURER          : MARRESEARCH                        
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : HKL-2000                           
REMARK 200  DATA SCALING SOFTWARE          : HKL-2000                           
REMARK 200                                                                      
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 30219                              
REMARK 200  RESOLUTION RANGE HIGH      (A) : 2.200                              
REMARK 200  RESOLUTION RANGE LOW       (A) : 40.000                             
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : 0.000                              
REMARK 200                                                                      
REMARK 200 OVERALL.                                                             
REMARK 200  COMPLETENESS FOR RANGE     (%) : 99.9                               
REMARK 200  DATA REDUNDANCY                : 8.000                              
REMARK 200  R MERGE                    (I) : 0.07200                            
REMARK 200  R SYM                      (I) : NULL                               
REMARK 200   FOR THE DATA SET  : 29.1000                            
REMARK 200                                                                      
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.                                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.20                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 2.28                     
REMARK 200  COMPLETENESS FOR SHELL     (%) : 100.0                              
REMARK 200  DATA REDUNDANCY IN SHELL       : 7.80                               
REMARK 200  R MERGE FOR SHELL          (I) : 0.30600                            
REMARK 200  R SYM FOR SHELL            (I) : NULL                               
REMARK 200   FOR SHELL         : 7.000                              
REMARK 200                                                                      
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH                              
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT        
REMARK 200 SOFTWARE USED: MOLREP                                                
REMARK 200 STARTING MODEL: PDB ENTRY 1FHJ                                       
REMARK 200                                                                      
REMARK 200 REMARK: NULL                                                         
REMARK 280                                                                      
REMARK 280 CRYSTAL                                                              
REMARK 280 SOLVENT CONTENT, VS   (%): 46.50                                     
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.30                     
REMARK 280                                                                      
REMARK 280 CRYSTALLIZATION CONDITIONS: 16 % POLYETHYLENEGLYCOL (PEG), 0.1       
REMARK 280  M HEPES NA, PH 7.8, VAPOR DIFFUSION, SITTING DROP, TEMPERATURE      
REMARK 280  293K                                                                
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY                                            
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 21 21 21                       
REMARK 290                                                                      
REMARK 290      SYMOP   SYMMETRY                                                
REMARK 290     NNNMMM   OPERATOR                                                
REMARK 290       1555   X,Y,Z                                                   
REMARK 290       2555   1/2-X,-Y,1/2+Z                                          
REMARK 290       3555   -X,1/2+Y,1/2-Z                                          
REMARK 290       4555   1/2+X,1/2-Y,-Z                                          
REMARK 290                                                                      
REMARK 290     WHERE NNN -> OPERATOR NUMBER                                     
REMARK 290           MMM -> TRANSLATION VECTOR                                  
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS                            
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM             
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY                
REMARK 290 RELATED MOLECULES.                                                   
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000       26.36550            
REMARK 290   SMTRY2   2  0.000000 -1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000       65.14250            
REMARK 290   SMTRY1   3 -1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000       42.11850            
REMARK 290   SMTRY3   3  0.000000  0.000000 -1.000000       65.14250            
REMARK 290   SMTRY1   4  1.000000  0.000000  0.000000       26.36550            
REMARK 290   SMTRY2   4  0.000000 -1.000000  0.000000       42.11850            
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000            
REMARK 290                                                                      
REMARK 290 REMARK: NULL                                                         
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 THIS ENTRY CONTAINS THE CRYSTALLOGRAPHIC ASYMMETRIC UNIT             
REMARK 300 WHICH CONSISTS OF 4 CHAIN(S). SEE REMARK 350 FOR                     
REMARK 300 INFORMATION ON GENERATING THE BIOLOGICAL MOLECULE(S).                
REMARK 350                                                                      
REMARK 350 GENERATING THE BIOMOLECULE                                           
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D                            
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     VAL B     1                                                      
REMARK 465     HIS B   146                                                      
REMARK 465     HIS D   146                                                      
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI                             
REMARK 500  FE    HEM B   200     O    HOH       2              1.98            
REMARK 500   SG   CYS B    93     CE2  TYR B   145              1.99            
REMARK 500  FE    HEM D   200     O    HOH       4              2.01            
REMARK 500  FE    HEM A   200     O    HOH       1              2.03            
REMARK 500  FE    HEM C   200     O    HOH       3              2.03            
REMARK 500   SG   CYS B    93     CD2  TYR B   145              2.06            
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND LENGTHS                                      
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,2(A3,1X,A1,I4,A1,1X,A4,3X),F6.3)                  
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: ENGH AND HUBER, 1991                                
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   RES CSSEQI ATM2   DEVIATION                     
REMARK 500    ILE A  17   CG1   ILE A  17   CD1   -0.109                        
REMARK 500    CYS D  93   CB    CYS D  93   SG     0.121                        
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: ENGH AND HUBER, 1991                                
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500    ASP A  47   N   -  CA  -  C   ANGL. DEV. = -9.0 DEGREES           
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: 1FHJ   RELATED DB: PDB                                   
REMARK 900 USED AS THE MODEL FOR THE MOLECULAR REPLACEMENT.                     
REMARK 999                                                                      
REMARK 999 SEQUENCE                                                             
REMARK 999 THE SEQUENCE OF THE PROTEIN HAS NOT BEEN DEPOSITED                   
REMARK 999 INTO ANY SEQUENCE DATABASE.                                          
DBREF  2B7H A    1   141  UNP    P60523   HBA_CHRBR        1    141             
DBREF  2B7H B    1   146  UNP    P60526   HBB_CHRBR        1    146             
DBREF  2B7H C    1   141  UNP    P60523   HBA_CHRBR        1    141             
DBREF  2B7H D    1   146  UNP    P60526   HBB_CHRBR        1    146             
SEQRES   1 A  141  VAL LEU SER PRO ALA ASP LYS THR ASN ILE LYS SER THR          
SEQRES   2 A  141  TRP ASP LYS ILE GLY GLY HIS ALA GLY ASP TYR GLY GLY          
SEQRES   3 A  141  GLU ALA LEU ASP ARG THR PHE GLN SER PHE PRO THR THR          
SEQRES   4 A  141  LYS THR TYR PHE PRO HIS PHE ASP LEU SER PRO GLY SER          
SEQRES   5 A  141  ALA GLN VAL LYS ALA HIS GLY LYS LYS VAL ALA ASP ALA          
SEQRES   6 A  141  LEU THR THR ALA VAL ALA HIS LEU ASP ASP LEU PRO GLY          
SEQRES   7 A  141  ALA LEU SER ALA LEU SER ASP LEU HIS ALA TYR LYS LEU          
SEQRES   8 A  141  ARG VAL ASP PRO VAL ASN PHE LYS LEU LEU SER HIS CYS          
SEQRES   9 A  141  LEU LEU VAL THR LEU ALA CYS HIS HIS PRO THR GLU PHE          
SEQRES  10 A  141  THR PRO ALA VAL HIS ALA SER LEU ASP LYS PHE PHE THR          
SEQRES  11 A  141  ALA VAL SER THR VAL LEU THR SER LYS TYR ARG                  
SEQRES   1 B  146  VAL HIS LEU THR ALA GLU GLU LYS SER LEU VAL SER GLY          
SEQRES   2 B  146  LEU TRP ALA LYS VAL ASN VAL ASP GLU VAL GLY GLY GLU          
SEQRES   3 B  146  ALA LEU GLY ARG LEU LEU ILE VAL TYR PRO TRP THR GLN          
SEQRES   4 B  146  ARG PHE PHE ASP SER PHE GLY ASP LEU SER THR PRO ASP          
SEQRES   5 B  146  SER VAL MET SER ASN ALA LYS VAL LYS ALA HIS GLY LYS          
SEQRES   6 B  146  LYS VAL LEU ASN SER PHE SER ASP GLY LEU LYS ASN LEU          
SEQRES   7 B  146  ASP ASN LEU LYS GLY THR PHE ALA LYS LEU SER GLU LEU          
SEQRES   8 B  146  HIS CYS ASP LYS LEU HIS VAL ASP PRO GLU ASN PHE LYS          
SEQRES   9 B  146  LEU LEU GLY ASN VAL LEU VAL CYS VAL LEU ALA HIS HIS          
SEQRES  10 B  146  PHE GLY LYS GLU PHE THR PRO GLN VAL GLN ALA ALA TYR          
SEQRES  11 B  146  GLN LYS VAL VAL ALA GLY VAL ALA ASN ALA LEU ALA HIS          
SEQRES  12 B  146  LYS TYR HIS                                                  
SEQRES   1 C  141  VAL LEU SER PRO ALA ASP LYS THR ASN ILE LYS SER THR          
SEQRES   2 C  141  TRP ASP LYS ILE GLY GLY HIS ALA GLY ASP TYR GLY GLY          
SEQRES   3 C  141  GLU ALA LEU ASP ARG THR PHE GLN SER PHE PRO THR THR          
SEQRES   4 C  141  LYS THR TYR PHE PRO HIS PHE ASP LEU SER PRO GLY SER          
SEQRES   5 C  141  ALA GLN VAL LYS ALA HIS GLY LYS LYS VAL ALA ASP ALA          
SEQRES   6 C  141  LEU THR THR ALA VAL ALA HIS LEU ASP ASP LEU PRO GLY          
SEQRES   7 C  141  ALA LEU SER ALA LEU SER ASP LEU HIS ALA TYR LYS LEU          
SEQRES   8 C  141  ARG VAL ASP PRO VAL ASN PHE LYS LEU LEU SER HIS CYS          
SEQRES   9 C  141  LEU LEU VAL THR LEU ALA CYS HIS HIS PRO THR GLU PHE          
SEQRES  10 C  141  THR PRO ALA VAL HIS ALA SER LEU ASP LYS PHE PHE THR          
SEQRES  11 C  141  ALA VAL SER THR VAL LEU THR SER LYS TYR ARG                  
SEQRES   1 D  146  VAL HIS LEU THR ALA GLU GLU LYS SER LEU VAL SER GLY          
SEQRES   2 D  146  LEU TRP ALA LYS VAL ASN VAL ASP GLU VAL GLY GLY GLU          
SEQRES   3 D  146  ALA LEU GLY ARG LEU LEU ILE VAL TYR PRO TRP THR GLN          
SEQRES   4 D  146  ARG PHE PHE ASP SER PHE GLY ASP LEU SER THR PRO ASP          
SEQRES   5 D  146  SER VAL MET SER ASN ALA LYS VAL LYS ALA HIS GLY LYS          
SEQRES   6 D  146  LYS VAL LEU ASN SER PHE SER ASP GLY LEU LYS ASN LEU          
SEQRES   7 D  146  ASP ASN LEU LYS GLY THR PHE ALA LYS LEU SER GLU LEU          
SEQRES   8 D  146  HIS CYS ASP LYS LEU HIS VAL ASP PRO GLU ASN PHE LYS          
SEQRES   9 D  146  LEU LEU GLY ASN VAL LEU VAL CYS VAL LEU ALA HIS HIS          
SEQRES  10 D  146  PHE GLY LYS GLU PHE THR PRO GLN VAL GLN ALA ALA TYR          
SEQRES  11 D  146  GLN LYS VAL VAL ALA GLY VAL ALA ASN ALA LEU ALA HIS          
SEQRES  12 D  146  LYS TYR HIS                                                  
HET    SO4    501       5                                                       
HET    SO4    502       5                                                       
HET    HEM  A 200      43                                                       
HET    HEM  B 200      43                                                       
HET    HEM  C 200      43                                                       
HET    HEM  D 200      43                                                       
HETNAM     SO4 SULFATE ION                                                      
HETNAM     HEM PROTOPORPHYRIN IX CONTAINING FE                                  
HETSYN     HEM HEME                                                             
FORMUL   5  SO4    2(O4 S 2-)                                                   
FORMUL   7  HEM    4(C34 H32 FE N4 O4)                                          
FORMUL  11  HOH   *443(H2 O)                                                    
HELIX    1   1 SER A    3  GLY A   18  1                                  16    
HELIX    2   2 HIS A   20  PHE A   36  1                                  17    
HELIX    3   3 PRO A   37  PHE A   43  5                                   7    
HELIX    4   4 SER A   52  HIS A   72  1                                  21    
HELIX    5   5 ASP A   75  LEU A   80  1                                   6    
HELIX    6   6 LEU A   80  LYS A   90  1                                  11    
HELIX    7   7 PRO A   95  HIS A  113  1                                  19    
HELIX    8   8 THR A  118  THR A  137  1                                  20    
HELIX    9   9 SER A  138  ARG A  141  5                                   4    
HELIX   10  10 THR B    4  ALA B   16  1                                  13    
HELIX   11  11 GLU B   22  TYR B   35  1                                  14    
HELIX   12  12 PRO B   36  GLY B   46  5                                  11    
HELIX   13  13 THR B   50  SER B   56  1                                   7    
HELIX   14  14 ASN B   57  LYS B   76  1                                  20    
HELIX   15  15 ASN B   80  LYS B   95  1                                  16    
HELIX   16  16 PRO B  100  GLY B  119  1                                  20    
HELIX   17  17 LYS B  120  PHE B  122  5                                   3    
HELIX   18  18 THR B  123  HIS B  143  1                                  21    
HELIX   19  19 SER C    3  GLY C   18  1                                  16    
HELIX   20  20 HIS C   20  PHE C   36  1                                  17    
HELIX   21  21 PRO C   37  PHE C   43  5                                   7    
HELIX   22  22 SER C   52  ALA C   71  1                                  20    
HELIX   23  23 HIS C   72  ASP C   74  5                                   3    
HELIX   24  24 ASP C   75  LEU C   80  1                                   6    
HELIX   25  25 LEU C   80  LYS C   90  1                                  11    
HELIX   26  26 PRO C   95  HIS C  113  1                                  19    
HELIX   27  27 THR C  118  THR C  137  1                                  20    
HELIX   28  28 SER C  138  ARG C  141  5                                   4    
HELIX   29  29 THR D    4  ALA D   16  1                                  13    
HELIX   30  30 GLU D   22  TYR D   35  1                                  14    
HELIX   31  31 PRO D   36  GLY D   46  5                                  11    
HELIX   32  32 THR D   50  SER D   56  1                                   7    
HELIX   33  33 ASN D   57  ASN D   77  1                                  21    
HELIX   34  34 ASN D   80  LYS D   95  1                                  16    
HELIX   35  35 PRO D  100  GLY D  119  1                                  20    
HELIX   36  36 LYS D  120  PHE D  122  5                                   3    
HELIX   37  37 THR D  123  HIS D  143  1                                  21    
LINK         NE2 HIS A  87                FE   HEM A 200                        
LINK         NE2 HIS C  87                FE   HEM C 200                        
LINK         NE2 HIS B  92                FE   HEM B 200                        
LINK         NE2 HIS D  92                FE   HEM D 200                        
CRYST1   52.731   84.237  130.285  90.00  90.00  90.00 P 21 21 21    8          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      0.018964  0.000000  0.000000        0.00000                         
SCALE2      0.000000  0.011871  0.000000        0.00000                         
SCALE3      0.000000  0.000000  0.007675        0.00000