PDB entry 2aa1

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HEADER    OXYGEN STORAGE/TRANSPORT                13-JUL-05   2AA1              
TITLE     CRYSTAL STRUCTURE OF THE CATHODIC HEMOGLOBIN ISOLATED FROM            
TITLE    2 THE ANTARCTIC FISH TREMATOMUS NEWNESI                                
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: HEMOGLOBIN ALPHA-1 CHAIN;                                  
COMPND   3 CHAIN: A, C;                                                         
COMPND   4 MOL_ID: 2;                                                           
COMPND   5 MOLECULE: HEMOGLOBIN BETA-C CHAIN;                                   
COMPND   6 CHAIN: B, D                                                          
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: TREMATOMUS NEWNESI;                             
SOURCE   3 ORGANISM_COMMON: DUSKY NOTOTHEN;                                     
SOURCE   4 MOL_ID: 2;                                                           
SOURCE   5 ORGANISM_SCIENTIFIC: TREMATOMUS NEWNESI;                             
SOURCE   6 ORGANISM_COMMON: DUSKY NOTOTHEN                                      
KEYWDS    HEMOGLOBIN, ROOT EFFECT, COOPERATIVITY, ANTARCTIC FISH                
EXPDTA    X-RAY DIFFRACTION                                                     
AUTHOR    L.MAZZARELLA,G.BONOMI,M.C.LUBRANO,A.MERLINO,A.RICCIO,                 
AUTHOR   2 A.VERGARA,L.VITAGLIANO,C.VERDE,G.DI PRISCO                           
REVDAT   2   24-JAN-06 2AA1    1       JRNL                                     
REVDAT   1   02-AUG-05 2AA1    0                                                
JRNL        AUTH   L.MAZZARELLA,G.BONOMI,M.C.LUBRANO,A.MERLINO,                 
JRNL        AUTH 2 A.RICCIO,A.VERGARA,L.VITAGLIANO,C.VERDE,G.DI PRISCO          
JRNL        TITL   MINIMAL STRUCTURAL REQUIREMENTS FOR ROOT EFFECT:             
JRNL        TITL 2 CRYSTAL STRUCTURE OF THE CATHODIC HEMOGLOBIN                 
JRNL        TITL 3 ISOLATED FROM THE ANTARCTIC FISH TREMATOMUS NEWNESI          
JRNL        REF    PROTEINS                      V.  62   316 2006              
JRNL        REFN   ASTM PSFGEY  US ISSN 0887-3585                               
REMARK   1                                                                      
REMARK   1 REFERENCE 1                                                          
REMARK   1  AUTH   L.MAZZARELLA,R.D'AVINO,G.DI PRISCO,C.SAVINO,                 
REMARK   1  AUTH 2 L.VITAGLIANO,P.C.E.MOODY,A.ZAGARI                            
REMARK   1  TITL   CRYSTAL STRUCTURE OF TREMATOMUS NEWNESI                      
REMARK   1  TITL 2 HAEMOGLOBIN RE-OPENS THE ROOT EFFECT QUESTION                
REMARK   1  REF    J.MOL.BIOL.                   V. 287   897 1999              
REMARK   1  REFN   ASTM JMOBAK  UK ISSN 0022-2836                               
REMARK   2                                                                      
REMARK   2 RESOLUTION. 1.80 ANGSTROMS.                                          
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   PROGRAM     : X-PLOR                                               
REMARK   3   AUTHORS     : BRUNGER                                              
REMARK   3                                                                      
REMARK   3  DATA USED IN REFINEMENT.                                            
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 1.80                           
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 20.00                          
REMARK   3   DATA CUTOFF            (SIGMA(F)) : 2.000                          
REMARK   3   DATA CUTOFF HIGH         (ABS(F)) : NULL                           
REMARK   3   DATA CUTOFF LOW          (ABS(F)) : NULL                           
REMARK   3   COMPLETENESS (WORKING+TEST)   (%) : NULL                           
REMARK   3   NUMBER OF REFLECTIONS             : 51907                          
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT.                                     
REMARK   3   CROSS-VALIDATION METHOD          : NULL                            
REMARK   3   FREE R VALUE TEST SET SELECTION  : RANDOM                          
REMARK   3   R VALUE            (WORKING SET) : 0.186                           
REMARK   3   FREE R VALUE                     : 0.220                           
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : NULL                            
REMARK   3   FREE R VALUE TEST SET COUNT      : 4603                            
REMARK   3   ESTIMATED ERROR OF FREE R VALUE  : NULL                            
REMARK   3                                                                      
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.                                  
REMARK   3   TOTAL NUMBER OF BINS USED           : NULL                         
REMARK   3   BIN RESOLUTION RANGE HIGH       (A) : NULL                         
REMARK   3   BIN RESOLUTION RANGE LOW        (A) : NULL                         
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : NULL                         
REMARK   3   REFLECTIONS IN BIN    (WORKING SET) : NULL                         
REMARK   3   BIN R VALUE           (WORKING SET) : NULL                         
REMARK   3   BIN FREE R VALUE                    : NULL                         
REMARK   3   BIN FREE R VALUE TEST SET SIZE  (%) : NULL                         
REMARK   3   BIN FREE R VALUE TEST SET COUNT     : NULL                         
REMARK   3   ESTIMATED ERROR OF BIN FREE R VALUE : NULL                         
REMARK   3                                                                      
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.                    
REMARK   3   PROTEIN ATOMS            : 4540                                    
REMARK   3   NUCLEIC ACID ATOMS       : 0                                       
REMARK   3   HETEROGEN ATOMS          : 172                                     
REMARK   3   SOLVENT ATOMS            : 369                                     
REMARK   3                                                                      
REMARK   3  B VALUES.                                                           
REMARK   3   FROM WILSON PLOT           (A**2) : NULL                           
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : NULL                           
REMARK   3   OVERALL ANISOTROPIC B VALUE.                                       
REMARK   3    B11 (A**2) : NULL                                                 
REMARK   3    B22 (A**2) : NULL                                                 
REMARK   3    B33 (A**2) : NULL                                                 
REMARK   3    B12 (A**2) : NULL                                                 
REMARK   3    B13 (A**2) : NULL                                                 
REMARK   3    B23 (A**2) : NULL                                                 
REMARK   3                                                                      
REMARK   3  ESTIMATED COORDINATE ERROR.                                         
REMARK   3   ESD FROM LUZZATI PLOT        (A) : NULL                            
REMARK   3   ESD FROM SIGMAA              (A) : NULL                            
REMARK   3   LOW RESOLUTION CUTOFF        (A) : NULL                            
REMARK   3                                                                      
REMARK   3  CROSS-VALIDATED ESTIMATED COORDINATE ERROR.                         
REMARK   3   ESD FROM C-V LUZZATI PLOT    (A) : NULL                            
REMARK   3   ESD FROM C-V SIGMAA          (A) : NULL                            
REMARK   3                                                                      
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES.                                   
REMARK   3   BOND LENGTHS                 (A) : NULL                            
REMARK   3   BOND ANGLES            (DEGREES) : NULL                            
REMARK   3   DIHEDRAL ANGLES        (DEGREES) : NULL                            
REMARK   3   IMPROPER ANGLES        (DEGREES) : NULL                            
REMARK   3                                                                      
REMARK   3  ISOTROPIC THERMAL MODEL : NULL                                      
REMARK   3                                                                      
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.    RMS    SIGMA                
REMARK   3   MAIN-CHAIN BOND              (A**2) : NULL  ; NULL                 
REMARK   3   MAIN-CHAIN ANGLE             (A**2) : NULL  ; NULL                 
REMARK   3   SIDE-CHAIN BOND              (A**2) : NULL  ; NULL                 
REMARK   3   SIDE-CHAIN ANGLE             (A**2) : NULL  ; NULL                 
REMARK   3                                                                      
REMARK   3  NCS MODEL : NULL                                                    
REMARK   3                                                                      
REMARK   3  NCS RESTRAINTS.                         RMS   SIGMA/WEIGHT          
REMARK   3   GROUP  1  POSITIONAL            (A) : NULL  ; NULL                 
REMARK   3   GROUP  1  B-FACTOR           (A**2) : NULL  ; NULL                 
REMARK   3                                                                      
REMARK   3  PARAMETER FILE  1  : NULL                                           
REMARK   3  TOPOLOGY FILE  1   : NULL                                           
REMARK   3                                                                      
REMARK   3  OTHER REFINEMENT REMARKS: NULL                                      
REMARK   4                                                                      
REMARK   4 2AA1 COMPLIES WITH FORMAT V. 3.0, 1-DEC-2006                         
REMARK   4                                                                      
REMARK   4 THIS IS THE REMEDIATED VERSION OF THIS PDB ENTRY.                    
REMARK   4 REMEDIATED DATA FILE REVISION 3.101 (2007-05-29)                     
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBJ .                              
REMARK 100 THE RCSB ID CODE IS RCSB033672.                                      
REMARK 200                                                                      
REMARK 200 EXPERIMENTAL DETAILS                                                 
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION                  
REMARK 200  DATE OF DATA COLLECTION        : 07-APR-2002                        
REMARK 200  TEMPERATURE           (KELVIN) : 100.0                              
REMARK 200  PH                             : 6.20                               
REMARK 200  NUMBER OF CRYSTALS USED        : 1                                  
REMARK 200                                                                      
REMARK 200  SYNCHROTRON              (Y/N) : Y                                  
REMARK 200  RADIATION SOURCE               : ESRF                               
REMARK 200  BEAMLINE                       : ID14-4                             
REMARK 200  X-RAY GENERATOR MODEL          : NULL                               
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M                                  
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.9393                             
REMARK 200  MONOCHROMATOR                  : NULL                               
REMARK 200  OPTICS                         : NULL                               
REMARK 200                                                                      
REMARK 200  DETECTOR TYPE                  : CCD                                
REMARK 200  DETECTOR MANUFACTURER          : ADSC QUANTUM 4                     
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : DENZO                              
REMARK 200  DATA SCALING SOFTWARE          : SCALEPACK                          
REMARK 200                                                                      
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : NULL                               
REMARK 200  RESOLUTION RANGE HIGH      (A) : NULL                               
REMARK 200  RESOLUTION RANGE LOW       (A) : NULL                               
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL                               
REMARK 200                                                                      
REMARK 200 OVERALL.                                                             
REMARK 200  COMPLETENESS FOR RANGE     (%) : NULL                               
REMARK 200  DATA REDUNDANCY                : NULL                               
REMARK 200  R MERGE                    (I) : NULL                               
REMARK 200  R SYM                      (I) : NULL                               
REMARK 200   FOR THE DATA SET  : NULL                               
REMARK 200                                                                      
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.                                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 1.80                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 1.88                     
REMARK 200  COMPLETENESS FOR SHELL     (%) : 77.0                               
REMARK 200  DATA REDUNDANCY IN SHELL       : NULL                               
REMARK 200  R MERGE FOR SHELL          (I) : NULL                               
REMARK 200  R SYM FOR SHELL            (I) : NULL                               
REMARK 200   FOR SHELL         : NULL                               
REMARK 200                                                                      
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH                              
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT        
REMARK 200 SOFTWARE USED: AMORE                                                 
REMARK 200 STARTING MODEL: 1HBH                                                 
REMARK 200                                                                      
REMARK 200 REMARK: NULL                                                         
REMARK 280                                                                      
REMARK 280 CRYSTAL                                                              
REMARK 280 SOLVENT CONTENT, VS   (%): 58.10                                     
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.94                     
REMARK 280                                                                      
REMARK 280 CRYSTALLIZATION CONDITIONS: 9-12%(W/V) PEG 6000, PHOSPHATE           
REMARK 280  BUFFER, PH 6.2, VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 298K     
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY                                            
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 1                              
REMARK 290                                                                      
REMARK 290      SYMOP   SYMMETRY                                                
REMARK 290     NNNMMM   OPERATOR                                                
REMARK 290       1555   X,Y,Z                                                   
REMARK 290                                                                      
REMARK 290     WHERE NNN -> OPERATOR NUMBER                                     
REMARK 290           MMM -> TRANSLATION VECTOR                                  
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS                            
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM             
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY                
REMARK 290 RELATED MOLECULES.                                                   
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 290                                                                      
REMARK 290 REMARK: NULL                                                         
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 THIS ENTRY CONTAINS THE CRYSTALLOGRAPHIC ASYMMETRIC UNIT             
REMARK 300 WHICH CONSISTS OF 4 CHAIN(S). SEE REMARK 350 FOR                     
REMARK 300 INFORMATION ON GENERATING THE BIOLOGICAL MOLECULE(S).                
REMARK 350                                                                      
REMARK 350 GENERATING THE BIOMOLECULE                                           
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D                            
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND LENGTHS                                      
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,2(A3,1X,A1,I4,A1,1X,A4,3X),F6.3)                  
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: ENGH AND HUBER, 1991                                
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   RES CSSEQI ATM2   DEVIATION                     
REMARK 500    ARG A  31   CB    ARG A  31   CG    -0.043                        
REMARK 500    MET C  82   SD    MET C  82   CE     0.040                        
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: ENGH AND HUBER, 1991                                
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500    ILE A  17   N   -  CA  -  C   ANGL. DEV. =  7.2 DEGREES           
REMARK 500    TYR A  90   N   -  CA  -  C   ANGL. DEV. =  6.8 DEGREES           
REMARK 500    TYR A 141   N   -  CA  -  C   ANGL. DEV. =  8.2 DEGREES           
REMARK 500    GLU B  19   N   -  CA  -  C   ANGL. DEV. = -7.2 DEGREES           
REMARK 500    TYR B  20   N   -  CA  -  C   ANGL. DEV. =  6.6 DEGREES           
REMARK 500    TYR B  49   N   -  CA  -  C   ANGL. DEV. =  6.9 DEGREES           
REMARK 500    GLU B  94   N   -  CA  -  C   ANGL. DEV. =  8.9 DEGREES           
REMARK 500    PHE B 118   N   -  CA  -  C   ANGL. DEV. =  6.7 DEGREES           
REMARK 500    ILE C  17   N   -  CA  -  C   ANGL. DEV. =  7.6 DEGREES           
REMARK 500    TYR C  90   N   -  CA  -  C   ANGL. DEV. =  6.8 DEGREES           
REMARK 500    TYR C 141   N   -  CA  -  C   ANGL. DEV. =  7.2 DEGREES           
REMARK 500    GLU D  19   N   -  CA  -  C   ANGL. DEV. = -7.7 DEGREES           
REMARK 500    TYR D  20   N   -  CA  -  C   ANGL. DEV. =  7.4 DEGREES           
REMARK 500    GLU D  94   N   -  CA  -  C   ANGL. DEV. =  8.3 DEGREES           
REMARK 500    LEU D 106   CA  -  CB  -  CG  ANGL. DEV. =  6.8 DEGREES           
REMARK 500    PHE D 118   N   -  CA  -  C   ANGL. DEV. =  6.7 DEGREES           
REMARK 500    LYS D 143   N   -  CA  -  C   ANGL. DEV. =  7.4 DEGREES           
REMARK 525                                                                      
REMARK 525 SOLVENT                                                              
REMARK 525 THE FOLLOWING SOLVENT MOLECULES LIE FARTHER THAN EXPECTED            
REMARK 525 FROM THE PROTEIN OR NUCLEIC ACID MOLECULE AND MAY BE                 
REMARK 525 ASSOCIATED WITH A SYMMETRY RELATED MOLECULE (M=MODEL                 
REMARK 525 NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE          
REMARK 525 NUMBER; I=INSERTION CODE):                                           
REMARK 525                                                                      
REMARK 525  M RES CSSEQI                                                        
REMARK 525    HOH  1206        DISTANCE = 11.86 ANGSTROMS                       
REMARK 525    HOH  1251        DISTANCE =  7.61 ANGSTROMS                       
REMARK 525    HOH  1292        DISTANCE = 11.82 ANGSTROMS                       
REMARK 525    HOH  1341        DISTANCE =  9.17 ANGSTROMS                       
DBREF  2AA1 A    1   142  UNP    P45718   HBA1_TRENE       1    142             
DBREF  2AA1 C    1   142  UNP    P45718   HBA1_TRENE       1    142             
DBREF  2AA1 B    1   146  UNP    P45721   HBBC_TRENE       1    146             
DBREF  2AA1 D    1   146  UNP    P45721   HBBC_TRENE       1    146             
SEQRES   1 A  142  SER LEU SER ASP LYS ASP LYS ALA ALA VAL ARG ALA LEU          
SEQRES   2 A  142  TRP SER LYS ILE GLY LYS SER SER ASP ALA ILE GLY ASN          
SEQRES   3 A  142  ASP ALA LEU SER ARG MET ILE VAL VAL TYR PRO GLN THR          
SEQRES   4 A  142  LYS ILE TYR PHE SER HIS TRP PRO ASP VAL THR PRO GLY          
SEQRES   5 A  142  SER PRO ASN ILE LYS ALA HIS GLY LYS LYS VAL MET GLY          
SEQRES   6 A  142  GLY ILE ALA LEU ALA VAL SER LYS ILE ASP ASP LEU LYS          
SEQRES   7 A  142  THR GLY LEU MET GLU LEU SER GLU GLN HIS ALA TYR LYS          
SEQRES   8 A  142  LEU ARG VAL ASP PRO SER ASN PHE LYS ILE LEU ASN HIS          
SEQRES   9 A  142  CYS ILE LEU VAL VAL ILE SER THR MET PHE PRO LYS GLU          
SEQRES  10 A  142  PHE THR PRO GLU ALA HIS VAL SER LEU ASP LYS PHE LEU          
SEQRES  11 A  142  SER GLY VAL ALA LEU ALA LEU ALA GLU ARG TYR ARG              
SEQRES   1 B  146  VAL GLU TRP THR ASP PHE GLU ARG ALA THR ILE LYS ASP          
SEQRES   2 B  146  ILE PHE SER LYS LEU GLU TYR ASP VAL VAL GLY PRO ALA          
SEQRES   3 B  146  THR LEU ALA ARG CYS LEU VAL VAL TYR PRO TRP THR GLN          
SEQRES   4 B  146  ARG TYR PHE GLY LYS PHE GLY ASN LEU TYR ASN ALA ALA          
SEQRES   5 B  146  ALA ILE ALA GLN ASN ALA MET VAL SER LYS HIS GLY THR          
SEQRES   6 B  146  THR ILE LEU ASN GLY LEU ASP ARG ALA VAL LYS ASN MET          
SEQRES   7 B  146  ASP ASP ILE THR ASN THR TYR ALA GLU LEU SER VAL LEU          
SEQRES   8 B  146  HIS SER GLU LYS LEU HIS VAL ASP PRO ASP ASN PHE LYS          
SEQRES   9 B  146  LEU LEU ALA ASP CYS LEU THR ILE VAL VAL ALA ALA ARG          
SEQRES  10 B  146  PHE GLY SER ALA PHE THR GLY GLU VAL GLN ALA ALA PHE          
SEQRES  11 B  146  GLN LYS PHE MET ALA VAL VAL VAL SER SER LEU GLY LYS          
SEQRES  12 B  146  GLN TYR ARG                                                  
SEQRES   1 C  142  SER LEU SER ASP LYS ASP LYS ALA ALA VAL ARG ALA LEU          
SEQRES   2 C  142  TRP SER LYS ILE GLY LYS SER SER ASP ALA ILE GLY ASN          
SEQRES   3 C  142  ASP ALA LEU SER ARG MET ILE VAL VAL TYR PRO GLN THR          
SEQRES   4 C  142  LYS ILE TYR PHE SER HIS TRP PRO ASP VAL THR PRO GLY          
SEQRES   5 C  142  SER PRO ASN ILE LYS ALA HIS GLY LYS LYS VAL MET GLY          
SEQRES   6 C  142  GLY ILE ALA LEU ALA VAL SER LYS ILE ASP ASP LEU LYS          
SEQRES   7 C  142  THR GLY LEU MET GLU LEU SER GLU GLN HIS ALA TYR LYS          
SEQRES   8 C  142  LEU ARG VAL ASP PRO SER ASN PHE LYS ILE LEU ASN HIS          
SEQRES   9 C  142  CYS ILE LEU VAL VAL ILE SER THR MET PHE PRO LYS GLU          
SEQRES  10 C  142  PHE THR PRO GLU ALA HIS VAL SER LEU ASP LYS PHE LEU          
SEQRES  11 C  142  SER GLY VAL ALA LEU ALA LEU ALA GLU ARG TYR ARG              
SEQRES   1 D  146  VAL GLU TRP THR ASP PHE GLU ARG ALA THR ILE LYS ASP          
SEQRES   2 D  146  ILE PHE SER LYS LEU GLU TYR ASP VAL VAL GLY PRO ALA          
SEQRES   3 D  146  THR LEU ALA ARG CYS LEU VAL VAL TYR PRO TRP THR GLN          
SEQRES   4 D  146  ARG TYR PHE GLY LYS PHE GLY ASN LEU TYR ASN ALA ALA          
SEQRES   5 D  146  ALA ILE ALA GLN ASN ALA MET VAL SER LYS HIS GLY THR          
SEQRES   6 D  146  THR ILE LEU ASN GLY LEU ASP ARG ALA VAL LYS ASN MET          
SEQRES   7 D  146  ASP ASP ILE THR ASN THR TYR ALA GLU LEU SER VAL LEU          
SEQRES   8 D  146  HIS SER GLU LYS LEU HIS VAL ASP PRO ASP ASN PHE LYS          
SEQRES   9 D  146  LEU LEU ALA ASP CYS LEU THR ILE VAL VAL ALA ALA ARG          
SEQRES  10 D  146  PHE GLY SER ALA PHE THR GLY GLU VAL GLN ALA ALA PHE          
SEQRES  11 D  146  GLN LYS PHE MET ALA VAL VAL VAL SER SER LEU GLY LYS          
SEQRES  12 D  146  GLN TYR ARG                                                  
HET    ACE  A   0       3                                                       
HET    ACE  C   0       3                                                       
HET    HEM  A 200      43                                                       
HET    HEM  B 400      43                                                       
HET    HEM  C 600      43                                                       
HET    HEM  D 800      43                                                       
HETNAM     ACE ACETYL GROUP                                                     
HETNAM     HEM PROTOPORPHYRIN IX CONTAINING FE                                  
HETSYN     HEM HEME                                                             
FORMUL   5  ACE    2(C2 H4 O)                                                   
FORMUL   7  HEM    4(C34 H32 FE N4 O4)                                          
FORMUL  11  HOH   *369(H2 O)                                                    
HELIX    1   1 SER A    3  GLY A   18  1                                  16    
HELIX    2   2 SER A   20  TYR A   36  1                                  17    
HELIX    3   3 PRO A   37  SER A   44  5                                   8    
HELIX    4   4 SER A   53  LYS A   73  1                                  21    
HELIX    5   5 ASP A   76  LEU A   81  1                                   6    
HELIX    6   6 LEU A   81  LYS A   91  1                                  11    
HELIX    7   7 PRO A   96  PHE A  114  1                                  19    
HELIX    8   8 THR A  119  ALA A  138  1                                  20    
HELIX    9   9 THR B    4  LEU B   18  1                                  15    
HELIX   10  10 GLU B   19  TYR B   35  1                                  17    
HELIX   11  11 PRO B   36  GLY B   46  5                                  11    
HELIX   12  12 ASN B   50  ASN B   57  1                                   8    
HELIX   13  13 ASN B   57  GLY B   70  1                                  14    
HELIX   14  14 LEU B   71  ASN B   77  1                                   7    
HELIX   15  15 ASP B   80  LYS B   95  1                                  16    
HELIX   16  16 PRO B  100  GLY B  119  1                                  20    
HELIX   17  17 SER B  120  PHE B  122  5                                   3    
HELIX   18  18 THR B  123  LYS B  143  1                                  21    
HELIX   19  19 SER C    3  GLY C   18  1                                  16    
HELIX   20  20 SER C   20  TYR C   36  1                                  17    
HELIX   21  21 PRO C   37  SER C   44  5                                   8    
HELIX   22  22 SER C   53  LYS C   73  1                                  21    
HELIX   23  23 ASP C   76  LEU C   81  1                                   6    
HELIX   24  24 LEU C   81  LYS C   91  1                                  11    
HELIX   25  25 PRO C   96  PHE C  114  1                                  19    
HELIX   26  26 THR C  119  GLU C  139  1                                  21    
HELIX   27  27 THR D    4  LEU D   18  1                                  15    
HELIX   28  28 GLU D   19  TYR D   35  1                                  17    
HELIX   29  29 PRO D   36  PHE D   42  5                                   7    
HELIX   30  30 ASN D   50  ASN D   57  1                                   8    
HELIX   31  31 ASN D   57  GLY D   70  1                                  14    
HELIX   32  32 LEU D   71  ASN D   77  1                                   7    
HELIX   33  33 ASP D   80  TYR D   85  1                                   6    
HELIX   34  34 TYR D   85  LYS D   95  1                                  11    
HELIX   35  35 PRO D  100  GLY D  119  1                                  20    
HELIX   36  36 SER D  120  PHE D  122  5                                   3    
HELIX   37  37 THR D  123  LYS D  143  1                                  21    
LINK         NE2 HIS A  88                FE   HEM A 200                        
LINK         NE2 HIS B  92                FE   HEM B 400                        
LINK         NE2 HIS C  88                FE   HEM C 600                        
LINK         NE2 HIS D  92                FE   HEM D 800                        
LINK         C   ACE A   0                 N   SER A   1                        
LINK         C   ACE C   0                 N   SER C   1                        
CRYST1   58.097   60.801   61.232  80.73  81.36  62.01 P 1           2          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      0.017210 -0.009150 -0.001670        0.00000                         
SCALE2      0.000000  0.018630 -0.001940        0.00000                         
SCALE3      0.000000  0.000000  0.016610        0.00000