PDB entry 1w92

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HEADER    OXYGEN STORAGE/TRANSPORT                28-SEP-04   1W92              
TITLE     THE STRUCTURE OF CARBOMONOXY MURINE NEUROGLOBIN REVEALS A             
TITLE    2 HEME-SLIDING MECHANISM FOR AFFINITY REGULATION                       
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: NEUROGLOBIN;                                               
COMPND   3 CHAIN: A;                                                            
COMPND   4 ENGINEERED: YES;                                                     
COMPND   5 MUTATION: YES;                                                       
COMPND   6 OTHER_DETAILS: CARBOMONOXY (CO) DERIVATIVE OF HEME FERROUS           
COMPND   7 (FE2) NEUROGLOBIN                                                    
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: MUS MUSCULUS;                                   
SOURCE   3 ORGANISM_COMMON: MOUSE;                                              
SOURCE   4 ORGAN: BRAIN;                                                        
SOURCE   5 TISSUE: NERVE;                                                       
SOURCE   6 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE   7 EXPRESSION_SYSTEM_STRAIN: BL21;                                      
SOURCE   8 EXPRESSION_SYSTEM_VARIANT: DE3(PLYS);                                
SOURCE   9 EXPRESSION_SYSTEM_VECTOR: PLASMID;                                   
SOURCE  10 EXPRESSION_SYSTEM_PLASMID: PET3A                                     
KEYWDS    CARBOMONOXY NEUROGLOBIN, GLOBIN, HEME-SLIDING, OXYGEN                 
KEYWDS   2 STORAGE/TRANSPORT                                                    
EXPDTA    X-RAY DIFFRACTION                                                     
AUTHOR    B.VALLONE,K.NIENHAUS,A.MATTHES,M.BRUNORI,G.U.NIENHAUS                 
REVDAT   3   17-MAR-05 1W92    1       ATOM                                     
REVDAT   2   22-DEC-04 1W92    1       JRNL                                     
REVDAT   1   02-NOV-04 1W92    0                                                
JRNL        AUTH   B.VALLONE,K.NIENHAUS,A.MATTHES,M.BRUNORI,                    
JRNL        AUTH 2 G.U.NIENHAUS                                                 
JRNL        TITL   THE STRUCTURE OF CARBONMONOXY NEUROGLOBIN REVEALS            
JRNL        TITL 2 A HEME-SLIDING MECHANISM FOR CONTROL OF LIGAND               
JRNL        TITL 3 AFFINITY.                                                    
JRNL        REF    PROC.NATL.ACAD.SCI.USA        V. 101 17351 2004              
JRNL        REFN   ASTM PNASA6  US ISSN 0027-8424                               
REMARK   1                                                                      
REMARK   1 REFERENCE 1                                                          
REMARK   1  AUTH   B.VALLONE,K.NIENHAUS,M.BRUNORI,G.U.NIENHAUS                  
REMARK   1  TITL   THE STRUCTURE OF MURINE NEUROGLOBIN: NOVEL                   
REMARK   1  TITL 2 PATHWAYS FOR LIGAND MIGRATION AND BINDING                    
REMARK   1  REF    PROTEINS                      V.  56    85 2004              
REMARK   1  REFN   ASTM PSFGEY  US ISSN 0887-3585                               
REMARK   2                                                                      
REMARK   2 RESOLUTION. 1.70 ANGSTROMS.                                          
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   PROGRAM     : REFMAC 5                                             
REMARK   3   AUTHORS     : MURSHUDOV,VAGIN,DODSON                               
REMARK   3                                                                      
REMARK   3    REFINEMENT TARGET : MAXIMUM LIKELIHOOD                            
REMARK   3                                                                      
REMARK   3  DATA USED IN REFINEMENT.                                            
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 1.70                           
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 15.00                          
REMARK   3   DATA CUTOFF            (SIGMA(F)) : 2.000                          
REMARK   3   COMPLETENESS FOR RANGE        (%) : 97.5                           
REMARK   3   NUMBER OF REFLECTIONS             : 882                            
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT.                                     
REMARK   3   CROSS-VALIDATION METHOD          : THROUGHUOT                      
REMARK   3   FREE R VALUE TEST SET SELECTION  : RANDOM                          
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.260                           
REMARK   3   R VALUE            (WORKING SET) : 0.260                           
REMARK   3   FREE R VALUE                     : 0.220                           
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 0.100                           
REMARK   3   FREE R VALUE TEST SET COUNT      : 903                             
REMARK   3                                                                      
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.                                  
REMARK   3   TOTAL NUMBER OF BINS USED           : NULL                         
REMARK   3   BIN RESOLUTION RANGE HIGH           : NULL                         
REMARK   3   BIN RESOLUTION RANGE LOW            : NULL                         
REMARK   3   REFLECTION IN BIN     (WORKING SET) : NULL                         
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : NULL                         
REMARK   3   BIN R VALUE           (WORKING SET) : NULL                         
REMARK   3   BIN FREE R VALUE SET COUNT          : NULL                         
REMARK   3   BIN FREE R VALUE                    : NULL                         
REMARK   3                                                                      
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.                    
REMARK   3   ALL ATOMS                : 1322                                    
REMARK   3                                                                      
REMARK   3  B VALUES.                                                           
REMARK   3   FROM WILSON PLOT           (A**2) : 22.80                          
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 27.30                          
REMARK   3   OVERALL ANISOTROPIC B VALUE.                                       
REMARK   3    B11 (A**2) : NULL                                                 
REMARK   3    B22 (A**2) : NULL                                                 
REMARK   3    B33 (A**2) : NULL                                                 
REMARK   3    B12 (A**2) : NULL                                                 
REMARK   3    B13 (A**2) : NULL                                                 
REMARK   3    B23 (A**2) : NULL                                                 
REMARK   3                                                                      
REMARK   3  ESTIMATED OVERALL COORDINATE ERROR.                                 
REMARK   3   ESU BASED ON R VALUE                            (A): NULL          
REMARK   3   ESU BASED ON FREE R VALUE                       (A): NULL          
REMARK   3   ESU BASED ON MAXIMUM LIKELIHOOD                 (A): NULL          
REMARK   3   ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2): NULL          
REMARK   3                                                                      
REMARK   3 CORRELATION COEFFICIENTS.                                            
REMARK   3   CORRELATION COEFFICIENT FO-FC      : NULL                          
REMARK   3   CORRELATION COEFFICIENT FO-FC FREE : NULL                          
REMARK   3                                                                      
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES        COUNT    RMS    WEIGHT      
REMARK   3   BOND LENGTHS REFINED ATOMS        (A):  NULL ;  NULL ;  NULL       
REMARK   3   BOND LENGTHS OTHERS               (A):  NULL ;  NULL ;  NULL       
REMARK   3   BOND ANGLES REFINED ATOMS   (DEGREES):  NULL ;  NULL ;  NULL       
REMARK   3   BOND ANGLES OTHERS          (DEGREES):  NULL ;  NULL ;  NULL       
REMARK   3   TORSION ANGLES, PERIOD 1    (DEGREES):  NULL ;  NULL ;  NULL       
REMARK   3   TORSION ANGLES, PERIOD 2    (DEGREES):  NULL ;  NULL ;  NULL       
REMARK   3   TORSION ANGLES, PERIOD 3    (DEGREES):  NULL ;  NULL ;  NULL       
REMARK   3   TORSION ANGLES, PERIOD 4    (DEGREES):  NULL ;  NULL ;  NULL       
REMARK   3   CHIRAL-CENTER RESTRAINTS       (A**3):  NULL ;  NULL ;  NULL       
REMARK   3   GENERAL PLANES REFINED ATOMS      (A):  NULL ;  NULL ;  NULL       
REMARK   3   GENERAL PLANES OTHERS             (A):  NULL ;  NULL ;  NULL       
REMARK   3   NON-BONDED CONTACTS REFINED ATOMS (A):  NULL ;  NULL ;  NULL       
REMARK   3   NON-BONDED CONTACTS OTHERS        (A):  NULL ;  NULL ;  NULL       
REMARK   3   NON-BONDED TORSION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL       
REMARK   3   NON-BONDED TORSION OTHERS         (A):  NULL ;  NULL ;  NULL       
REMARK   3   H-BOND (X...Y) REFINED ATOMS      (A):  NULL ;  NULL ;  NULL       
REMARK   3   H-BOND (X...Y) OTHERS             (A):  NULL ;  NULL ;  NULL       
REMARK   3   POTENTIAL METAL-ION REFINED ATOMS (A):  NULL ;  NULL ;  NULL       
REMARK   3   POTENTIAL METAL-ION OTHERS        (A):  NULL ;  NULL ;  NULL       
REMARK   3   SYMMETRY VDW REFINED ATOMS        (A):  NULL ;  NULL ;  NULL       
REMARK   3   SYMMETRY VDW OTHERS               (A):  NULL ;  NULL ;  NULL       
REMARK   3   SYMMETRY H-BOND REFINED ATOMS     (A):  NULL ;  NULL ;  NULL       
REMARK   3   SYMMETRY H-BOND OTHERS            (A):  NULL ;  NULL ;  NULL       
REMARK   3   SYMMETRY METAL-ION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL       
REMARK   3   SYMMETRY METAL-ION OTHERS         (A):  NULL ;  NULL ;  NULL       
REMARK   3                                                                      
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.     COUNT   RMS    WEIGHT      
REMARK   3   MAIN-CHAIN BOND REFINED ATOMS  (A**2):  NULL ;  NULL ;  NULL       
REMARK   3   MAIN-CHAIN BOND OTHER ATOMS    (A**2):  NULL ;  NULL ;  NULL       
REMARK   3   MAIN-CHAIN ANGLE REFINED ATOMS (A**2):  NULL ;  NULL ;  NULL       
REMARK   3   SIDE-CHAIN BOND REFINED ATOMS  (A**2):  NULL ;  NULL ;  NULL       
REMARK   3   SIDE-CHAIN ANGLE REFINED ATOMS (A**2):  NULL ;  NULL ;  NULL       
REMARK   3                                                                      
REMARK   3 ANISOTROPIC THERMAL FACTOR RESTRAINTS.    COUNT   RMS   WEIGHT       
REMARK   3   RIGID-BOND RESTRAINTS          (A**2):  NULL ;  NULL ;  NULL       
REMARK   3   SPHERICITY; FREE ATOMS         (A**2):  NULL ;  NULL ;  NULL       
REMARK   3   SPHERICITY; BONDED ATOMS       (A**2):  NULL ;  NULL ;  NULL       
REMARK   3                                                                      
REMARK   3  NCS RESTRAINTS STATISTICS                                           
REMARK   3   NUMBER OF DIFFERENT NCS GROUPS : 0                                 
REMARK   3                                                                      
REMARK   3  TLS DETAILS                                                         
REMARK   3   NUMBER OF TLS GROUPS  : 0                                          
REMARK   3                                                                      
REMARK   3  BULK SOLVENT MODELLING.                                             
REMARK   3   METHOD USED : NULL                                                 
REMARK   3   PARAMETERS FOR MASK CALCULATION                                    
REMARK   3   VDW PROBE RADIUS   : NULL                                          
REMARK   3   ION PROBE RADIUS   : NULL                                          
REMARK   3   SHRINKAGE RADIUS   : NULL                                          
REMARK   3                                                                      
REMARK   3  OTHER REFINEMENT REMARKS: HYDROGENS HAVE BEEN ADDED IN THE          
REMARK   3  RIDING POSITIONS.                                                   
REMARK   4                                                                      
REMARK   4 1W92 COMPLIES WITH FORMAT V. 3.0, 1-DEC-2006                         
REMARK   4                                                                      
REMARK   4 THIS IS THE REMEDIATED VERSION OF THIS PDB ENTRY.                    
REMARK   4 REMEDIATED DATA FILE REVISION 3.102 (2007-05-31)                     
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY EBI  .                              
REMARK 100 THE EBI ID CODE IS  EBI-21181 .                                      
REMARK 200                                                                      
REMARK 200 EXPERIMENTAL DETAILS                                                 
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION                  
REMARK 200  DATE OF DATA COLLECTION        : 20-OCT-2003                        
REMARK 200  TEMPERATURE           (KELVIN) : 100.0                              
REMARK 200  PH                             : 7.50                               
REMARK 200  NUMBER OF CRYSTALS USED        : 1                                  
REMARK 200                                                                      
REMARK 200  SYNCHROTRON              (Y/N) : Y                                  
REMARK 200  RADIATION SOURCE               : ELETTRA                            
REMARK 200  BEAMLINE                       : 5.2R                               
REMARK 200  X-RAY GENERATOR MODEL          : NULL                               
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M                                  
REMARK 200  WAVELENGTH OR RANGE        (A) : 1                                  
REMARK 200  MONOCHROMATOR                  : DOUBLE-CRYSTAL MONOCHROMATOR       
REMARK 200                                   (SI(111) AND SI(220) )             
REMARK 200  OPTICS                         : TOROIDAL FOCUSSING MIRROR          
REMARK 200                                   WITH A HORIZONTAL ACCEPTANCE       
REMARK 200                                   OF 2.8 MRAD                        
REMARK 200                                                                      
REMARK 200  DETECTOR TYPE                  : CCD                                
REMARK 200  DETECTOR MANUFACTURER          : MAR                                
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : DENZO                              
REMARK 200  DATA SCALING SOFTWARE          : SCALEPACK                          
REMARK 200                                                                      
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 92704                              
REMARK 200  RESOLUTION RANGE HIGH      (A) : 1.700                              
REMARK 200  RESOLUTION RANGE LOW       (A) : 15.000                             
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : 2.000                              
REMARK 200                                                                      
REMARK 200 OVERALL.                                                             
REMARK 200  COMPLETENESS FOR RANGE     (%) : 94.8                               
REMARK 200  DATA REDUNDANCY                : 2.500                              
REMARK 200  R MERGE                    (I) : 0.07000                            
REMARK 200  R SYM                      (I) : NULL                               
REMARK 200   FOR THE DATA SET  : 20.8000                            
REMARK 200                                                                      
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.                                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 1.70                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 1.73                     
REMARK 200  COMPLETENESS FOR SHELL     (%) : 97.5                               
REMARK 200  DATA REDUNDANCY IN SHELL       : 2.39                               
REMARK 200  R MERGE FOR SHELL          (I) : 0.23000                            
REMARK 200  R SYM FOR SHELL            (I) : NULL                               
REMARK 200   FOR SHELL         : 2.940                              
REMARK 200                                                                      
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH                              
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: OTHER                        
REMARK 200 SOFTWARE USED: NULL                                                  
REMARK 200 STARTING MODEL: PDB ENTRY 1Q1F                                       
REMARK 200                                                                      
REMARK 200 REMARK: NULL                                                         
REMARK 280                                                                      
REMARK 280 CRYSTAL                                                              
REMARK 280 SOLVENT CONTENT, VS   (%): 47.16                                     
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.35                     
REMARK 280                                                                      
REMARK 280 CRYSTALLIZATION CONDITIONS: PH 7.5                                   
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY                                            
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: H 3 2                            
REMARK 290                                                                      
REMARK 290      SYMOP   SYMMETRY                                                
REMARK 290     NNNMMM   OPERATOR                                                
REMARK 290       1555   X,Y,Z                                                   
REMARK 290       2555   -Y,X-Y,Z                                                
REMARK 290       3555   -X+Y,-X,Z                                               
REMARK 290       4555   Y,X,-Z                                                  
REMARK 290       5555   X-Y,-Y,-Z                                               
REMARK 290       6555   -X,-X+Y,-Z                                              
REMARK 290       7555   2/3+X,1/3+Y,1/3+Z                                       
REMARK 290       8555   2/3-Y,1/3+X-Y,1/3+Z                                     
REMARK 290       9555   2/3-X+Y,1/3-X,1/3+Z                                     
REMARK 290      10555   2/3+Y,1/3+X,1/3-Z                                       
REMARK 290      11555   2/3+X-Y,1/3-Y,1/3-Z                                     
REMARK 290      12555   2/3-X,1/3-X+Y,1/3-Z                                     
REMARK 290      13555   1/3+X,2/3+Y,2/3+Z                                       
REMARK 290      14555   1/3-Y,2/3+X-Y,2/3+Z                                     
REMARK 290      15555   1/3-X+Y,2/3-X,2/3+Z                                     
REMARK 290      16555   1/3+Y,2/3+X,2/3-Z                                       
REMARK 290      17555   1/3+X-Y,2/3-Y,2/3-Z                                     
REMARK 290      18555   1/3-X,2/3-X+Y,2/3-Z                                     
REMARK 290                                                                      
REMARK 290     WHERE NNN -> OPERATOR NUMBER                                     
REMARK 290           MMM -> TRANSLATION VECTOR                                  
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS                            
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM             
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY                
REMARK 290 RELATED MOLECULES.                                                   
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY1   2 -0.500000 -0.866025  0.000000        0.00000            
REMARK 290   SMTRY2   2  0.866025 -0.500000  0.000000        0.00000            
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY1   3 -0.500000  0.866025  0.000000        0.00000            
REMARK 290   SMTRY2   3 -0.866025 -0.500000  0.000000        0.00000            
REMARK 290   SMTRY3   3  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY1   4 -0.500000  0.866025  0.000000        0.00000            
REMARK 290   SMTRY2   4  0.866025  0.500000  0.000000        0.00000            
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000            
REMARK 290   SMTRY1   5  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   5  0.000000 -1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   5  0.000000  0.000000 -1.000000        0.00000            
REMARK 290   SMTRY1   6 -0.500000 -0.866025  0.000000        0.00000            
REMARK 290   SMTRY2   6 -0.866025  0.500000  0.000000        0.00000            
REMARK 290   SMTRY3   6  0.000000  0.000000 -1.000000        0.00000            
REMARK 290   SMTRY1   7  1.000000  0.000000  0.000000       44.18650            
REMARK 290   SMTRY2   7  0.000000  1.000000  0.000000       25.51109            
REMARK 290   SMTRY3   7  0.000000  0.000000  1.000000       36.99433            
REMARK 290   SMTRY1   8 -0.500000 -0.866025  0.000000       44.18650            
REMARK 290   SMTRY2   8  0.866025 -0.500000  0.000000       25.51109            
REMARK 290   SMTRY3   8  0.000000  0.000000  1.000000       36.99433            
REMARK 290   SMTRY1   9 -0.500000  0.866025  0.000000       44.18650            
REMARK 290   SMTRY2   9 -0.866025 -0.500000  0.000000       25.51109            
REMARK 290   SMTRY3   9  0.000000  0.000000  1.000000       36.99433            
REMARK 290   SMTRY1  10 -0.500000  0.866025  0.000000       44.18650            
REMARK 290   SMTRY2  10  0.866025  0.500000  0.000000       25.51109            
REMARK 290   SMTRY3  10  0.000000  0.000000 -1.000000       36.99433            
REMARK 290   SMTRY1  11  1.000000  0.000000  0.000000       44.18650            
REMARK 290   SMTRY2  11  0.000000 -1.000000  0.000000       25.51109            
REMARK 290   SMTRY3  11  0.000000  0.000000 -1.000000       36.99433            
REMARK 290   SMTRY1  12 -0.500000 -0.866025  0.000000       44.18650            
REMARK 290   SMTRY2  12 -0.866025  0.500000  0.000000       25.51109            
REMARK 290   SMTRY3  12  0.000000  0.000000 -1.000000       36.99433            
REMARK 290   SMTRY1  13  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2  13  0.000000  1.000000  0.000000       51.02218            
REMARK 290   SMTRY3  13  0.000000  0.000000  1.000000       73.98867            
REMARK 290   SMTRY1  14 -0.500000 -0.866025  0.000000        0.00000            
REMARK 290   SMTRY2  14  0.866025 -0.500000  0.000000       51.02218            
REMARK 290   SMTRY3  14  0.000000  0.000000  1.000000       73.98867            
REMARK 290   SMTRY1  15 -0.500000  0.866025  0.000000        0.00000            
REMARK 290   SMTRY2  15 -0.866025 -0.500000  0.000000       51.02218            
REMARK 290   SMTRY3  15  0.000000  0.000000  1.000000       73.98867            
REMARK 290   SMTRY1  16 -0.500000  0.866025  0.000000        0.00000            
REMARK 290   SMTRY2  16  0.866025  0.500000  0.000000       51.02218            
REMARK 290   SMTRY3  16  0.000000  0.000000 -1.000000       73.98867            
REMARK 290   SMTRY1  17  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2  17  0.000000 -1.000000  0.000000       51.02218            
REMARK 290   SMTRY3  17  0.000000  0.000000 -1.000000       73.98867            
REMARK 290   SMTRY1  18 -0.500000 -0.866025  0.000000        0.00000            
REMARK 290   SMTRY2  18 -0.866025  0.500000  0.000000       51.02218            
REMARK 290   SMTRY3  18  0.000000  0.000000 -1.000000       73.98867            
REMARK 290                                                                      
REMARK 290 REMARK: NULL                                                         
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 THIS ENTRY CONTAINS THE CRYSTALLOGRAPHIC ASYMMETRIC UNIT             
REMARK 300 WHICH CONSISTS OF 1 CHAIN(S). SEE REMARK 350 FOR                     
REMARK 300 INFORMATION ON GENERATING THE BIOLOGICAL MOLECULE(S).                
REMARK 350                                                                      
REMARK 350 GENERATING THE BIOMOLECULE                                           
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A                                     
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350   BIOMT1   2 -0.500000 -0.866025  0.000000       44.18650            
REMARK 350   BIOMT2   2  0.866025 -0.500000  0.000000       76.53326            
REMARK 350   BIOMT3   2  0.000000  0.000000  1.000000        0.00000            
REMARK 350   BIOMT1   3 -0.500000  0.866025  0.000000      -44.18650            
REMARK 350   BIOMT2   3 -0.866025 -0.500000  0.000000       76.53326            
REMARK 350   BIOMT3   3  0.000000  0.000000  1.000000        0.00000            
REMARK 350   BIOMT1   4 -0.500000  0.866025  0.000000      -44.18650            
REMARK 350   BIOMT2   4  0.866025  0.500000  0.000000       25.51109            
REMARK 350   BIOMT3   4  0.000000  0.000000 -1.000000       36.99433            
REMARK 350   BIOMT1   5  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   5  0.000000 -1.000000  0.000000      102.04435            
REMARK 350   BIOMT3   5  0.000000  0.000000 -1.000000       36.99433            
REMARK 350   BIOMT1   6 -0.500000 -0.866025  0.000000       44.18650            
REMARK 350   BIOMT2   6 -0.866025  0.500000  0.000000       25.51109            
REMARK 350   BIOMT3   6  0.000000  0.000000 -1.000000       36.99433            
REMARK 350 APPLY THE FOLLOWING TO CHAINS: Z                                     
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     MET A     1                                                      
REMARK 465     GLU A     2                                                      
REMARK 465     ASP A   149                                                      
REMARK 465     GLY A   150                                                      
REMARK 465     GLU A   151                                                      
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI                             
REMARK 500   NE2  HIS A    96    FE    HEM A  1149              2.11            
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: ENGH AND HUBER, 1991                                
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500    ARG A  18   CD  -  NE  -  CZ  ANGL. DEV. = 24.0 DEGREES           
REMARK 500    ARG A 135   CD  -  NE  -  CZ  ANGL. DEV. = 43.7 DEGREES           
REMARK 525                                                                      
REMARK 525 SOLVENT                                                              
REMARK 525 THE FOLLOWING SOLVENT MOLECULES LIE FARTHER THAN EXPECTED            
REMARK 525 FROM THE PROTEIN OR NUCLEIC ACID MOLECULE AND MAY BE                 
REMARK 525 ASSOCIATED WITH A SYMMETRY RELATED MOLECULE (M=MODEL                 
REMARK 525 NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE          
REMARK 525 NUMBER; I=INSERTION CODE):                                           
REMARK 525                                                                      
REMARK 525  M RES CSSEQI                                                        
REMARK 525    HOH Z  34        DISTANCE =  6.11 ANGSTROMS                       
REMARK 525    HOH Z  37        DISTANCE =  5.48 ANGSTROMS                       
REMARK 800                                                                      
REMARK 800 SITE                                                                 
REMARK 800 SITE_IDENTIFIER: AC1                                                 
REMARK 800 SITE_DESCRIPTION: CMO BINDING SITE FOR CHAIN A                       
DBREF  1W92 A    1   151  UNP    Q9ER97   NGB_MOUSE        1    151             
SEQADV 1W92 SER A   55  UNP  Q9ER97    CYS    55 ENGINEERED MUTATION            
SEQADV 1W92 SER A  120  UNP  Q9ER97    CYS   120 ENGINEERED MUTATION            
SEQRES   1 A  151  MET GLU ARG PRO GLU SER GLU LEU ILE ARG GLN SER TRP          
SEQRES   2 A  151  ARG VAL VAL SER ARG SER PRO LEU GLU HIS GLY THR VAL          
SEQRES   3 A  151  LEU PHE ALA ARG LEU PHE ALA LEU GLU PRO SER LEU LEU          
SEQRES   4 A  151  PRO LEU PHE GLN TYR ASN GLY ARG GLN PHE SER SER PRO          
SEQRES   5 A  151  GLU ASP SER LEU SER SER PRO GLU PHE LEU ASP HIS ILE          
SEQRES   6 A  151  ARG LYS VAL MET LEU VAL ILE ASP ALA ALA VAL THR ASN          
SEQRES   7 A  151  VAL GLU ASP LEU SER SER LEU GLU GLU TYR LEU THR SER          
SEQRES   8 A  151  LEU GLY ARG LYS HIS ARG ALA VAL GLY VAL ARG LEU SER          
SEQRES   9 A  151  SER PHE SER THR VAL GLY GLU SER LEU LEU TYR MET LEU          
SEQRES  10 A  151  GLU LYS SER LEU GLY PRO ASP PHE THR PRO ALA THR ARG          
SEQRES  11 A  151  THR ALA TRP SER ARG LEU TYR GLY ALA VAL VAL GLN ALA          
SEQRES  12 A  151  MET SER ARG GLY TRP ASP GLY GLU                              
HET    HEM  A1149      43                                                       
HET    CMO  A1150       2                                                       
HETNAM     HEM PROTOPORPHYRIN IX CONTAINING FE                                  
HETNAM     CMO CARBON MONOXIDE                                                  
HETSYN     HEM HEME                                                             
FORMUL   2  HEM    C34 H32 FE N4 O4                                             
FORMUL   3  CMO    C O                                                          
FORMUL   4  HOH   *107(H2 O)                                                    
HELIX    1   1 PRO A    4  ARG A   18  1                                  15    
HELIX    2   2 SER A   19  GLU A   35  1                                  17    
HELIX    3   3 PRO A   36  PHE A   42  5                                   7    
HELIX    4   4 SER A   51  SER A   57  1                                   7    
HELIX    5   5 SER A   58  ASN A   78  1                                  21    
HELIX    6   6 LEU A   82  SER A   84  5                                   3    
HELIX    7   7 LEU A   85  VAL A   99  1                                  15    
HELIX    8   8 ARG A  102  SER A  104  5                                   3    
HELIX    9   9 SER A  105  GLY A  122  1                                  18    
HELIX   10  10 PRO A  123  PHE A  125  5                                   3    
HELIX   11  11 THR A  126  ARG A  146  1                                  21    
LINK        FE   HEM A1149                 C   CMO A1150                        
SITE     1 AC1 13 PHE A  42  TYR A  44  HIS A  64  LYS A  67                    
SITE     2 AC1 13 LEU A  92  LYS A  95  HIS A  96  SER A 105                    
SITE     3 AC1 13 PHE A 106  TYR A 137  MET A 144  HOH Z  73                    
SITE     4 AC1 13 HOH Z 106                                                     
SITE     1 AC2  2 PHE A  28  HIS A  64                                          
CRYST1   88.373   88.373  110.983  90.00  90.00 120.00 H 3 2        18          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      0.011320  0.006530  0.000000        0.00000                         
SCALE2      0.000000  0.013070  0.000000        0.00000                         
SCALE3      0.000000  0.000000  0.009010        0.00000