PDB entry 1fyc

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HEADER    TRANSFERASE                             21-FEB-97   1FYC              
TITLE     INNER LIPOYL DOMAIN FROM HUMAN PYRUVATE DEHYDROGENASE (PDH)           
TITLE    2 COMPLEX, NMR, 1 STRUCTURE                                            
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: DIHYDROLIPOAMIDE ACETYLTRANSFERASE (E2P);                  
COMPND   3 CHAIN: A;                                                            
COMPND   4 FRAGMENT: LIPOYL DOMAIN;                                             
COMPND   5 EC: 2.3.1.12;                                                        
COMPND   6 ENGINEERED: YES;                                                     
COMPND   7 OTHER_DETAILS: DIHYDROLIPOAMIDE ACETYLTRANSFERASE SUBUNIT            
COMPND   8 OF THE PYRUVATE DEHYDROGENASE (PDH) MULTIENZYME COMPLEX              
COMPND   9 (UNLIPOYLATED DOMAIN)                                                
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   3 ORGANISM_COMMON: HUMAN;                                              
SOURCE   4 ORGAN: LIVER;                                                        
SOURCE   5 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE   6 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;                              
SOURCE   7 EXPRESSION_SYSTEM_PLASMID: HLIP;                                     
SOURCE   8 OTHER_DETAILS: EXPRESSED AS A GST FUSION PROTEIN                     
KEYWDS    TRANSFERASE, ACYLTRANSFERASE DIHYDROLIPOAMIDE, SUBUNIT,               
KEYWDS   2 UNLIPOYLATED                                                         
EXPDTA    NMR                                                                   
AUTHOR    M.J.HOWARD,C.FULLER,R.W.BROADHURST,J.QUINN,S.J.YEAMAN,                
AUTHOR   2 R.N.PERHAM                                                           
REVDAT   1   04-SEP-97 1FYC    0                                                
JRNL        AUTH   M.J.HOWARD,C.FULLER,R.W.BROADHURST,R.N.PERHAM,               
JRNL        AUTH 2 J.G.TANG,J.QUINN,A.G.DIAMOND,S.J.YEAMAN                      
JRNL        TITL   THREE-DIMENSIONAL STRUCTURE OF THE MAJOR                     
JRNL        TITL 2 AUTOANTIGEN IN PRIMARY BILIARY CIRRHOSIS.                    
JRNL        REF    GASTROENTEROLOGY              V. 115   139 1998              
JRNL        REFN   ASTM GASTAB  US ISSN 0016-5085                               
REMARK   1                                                                      
REMARK   2                                                                      
REMARK   2 RESOLUTION. NOT APPLICABLE.                                          
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   PROGRAM     : X-PLOR 3.1                                           
REMARK   3   AUTHORS     : BRUNGER                                              
REMARK   3                                                                      
REMARK   3  OTHER REFINEMENT REMARKS: REFINEMENT DETAILS CAM BE FOUND IN        
REMARK   3  P.M. RICAUD ET AL., JOURNAL OF MOLECULAR BIOLOGY, 264, 179-         
REMARK   3  190, 1996                                                           
REMARK   4                                                                      
REMARK   4 1FYC COMPLIES WITH FORMAT V. 3.0, 1-DEC-2006                         
REMARK   4                                                                      
REMARK   4 THIS IS THE REMEDIATED VERSION OF THIS PDB ENTRY.                    
REMARK   4 REMEDIATED DATA FILE REVISION 3.100 (2007-03-17)                     
REMARK 210                                                                      
REMARK 210 EXPERIMENTAL DETAILS                                                 
REMARK 210  EXPERIMENT TYPE                : NMR                                
REMARK 210  TEMPERATURE           (KELVIN) : 308                                
REMARK 210  PH                             : 6.5                                
REMARK 210  IONIC STRENGTH                 : NULL                               
REMARK 210  PRESSURE                       : NULL                               
REMARK 210  SAMPLE CONTENTS                : NULL                               
REMARK 210                                                                      
REMARK 210  NMR EXPERIMENTS CONDUCTED      : NOESY, COSY, TCOSY, HSQC-          
REMARK 210                                   NOESY, HSQC-TOCSY                  
REMARK 210  SPECTROMETER FIELD STRENGTH    : 500 MHZ                            
REMARK 210  SPECTROMETER MODEL             : AM500                              
REMARK 210  SPECTROMETER MANUFACTURER      : BRUKER                             
REMARK 210                                                                      
REMARK 210  STRUCTURE DETERMINATION.                                            
REMARK 210   SOFTWARE USED                 : ANSIG 3.3                          
REMARK 210   METHOD USED                   : SIMULATED ANNEALING                
REMARK 210                                                                      
REMARK 210 CONFORMERS, NUMBER CALCULATED   : 80                                 
REMARK 210 CONFORMERS, NUMBER SUBMITTED    : 1                                  
REMARK 210 CONFORMERS, SELECTION CRITERIA  : MEAN STRUCTURE FROM 26 CHOSEN      
REMARK 210                                   HAVING LEAST RESTRAINT             
REMARK 210                                   VIOLATION                          
REMARK 210                                                                      
REMARK 210 BEST REPRESENTATIVE CONFORMER IN THIS ENSEMBLE : NULL                
REMARK 210                                                                      
REMARK 210 REMARK: NULL                                                         
REMARK 215                                                                      
REMARK 215 NMR STUDY                                                            
REMARK 215 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM SOLUTION           
REMARK 215 NMR DATA.  PROTEIN DATA BANK CONVENTIONS REQUIRE THAT                
REMARK 215 CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES ON              
REMARK 215 THESE RECORDS ARE MEANINGLESS.                                       
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    TYR A   6      151.58     59.89                                   
REMARK 500    ALA A  89      138.28     75.17                                   
DBREF  1FYC A    1   106  UNP    P10515   ODP2_HUMAN     179    282             
SEQADV 1FYC ASN A    3  UNP  P10515              INSERTION                      
SEQADV 1FYC MET A    4  UNP  P10515              INSERTION                      
SEQRES   1 A  106  GLY SER ASN MET SER TYR PRO PRO HIS MET GLN VAL LEU          
SEQRES   2 A  106  LEU PRO ALA LEU SER PRO THR MET THR MET GLY THR VAL          
SEQRES   3 A  106  GLN ARG TRP GLU LYS LYS VAL GLY GLU LYS LEU SER GLU          
SEQRES   4 A  106  GLY ASP LEU LEU ALA GLU ILE GLU THR ASP LYS ALA THR          
SEQRES   5 A  106  ILE GLY PHE GLU VAL GLN GLU GLU GLY TYR LEU ALA LYS          
SEQRES   6 A  106  ILE LEU VAL PRO GLU GLY THR ARG ASP VAL PRO LEU GLY          
SEQRES   7 A  106  THR PRO LEU CYS ILE ILE VAL GLU LYS GLU ALA ASP ILE          
SEQRES   8 A  106  SER ALA PHE ALA ASP TYR ARG PRO THR GLU VAL THR ASP          
SEQRES   9 A  106  LEU LYS                                                      
SHEET    1  S1 4 MET A  10  LEU A  13  0                                        
SHEET    2  S1 4 PRO A  80  VAL A  85 -1                                        
SHEET    3  S1 4 GLU A  60  ILE A  66 -1                                        
SHEET    4  S1 4 GLY A  34  SER A  38 -1                                        
SHEET    1  S2 4 THR A  52  VAL A  57  0                                        
SHEET    2  S2 4 ASP A  41  THR A  48 -1                                        
SHEET    3  S2 4 THR A  25  TRP A  29 -1                                        
SHEET    4  S2 4 THR A  72  VAL A  75 -1                                        
TURN     1  T1 GLU A  30  VAL A  33                                             
TURN     2  T2 GLU A  39  GLY A  40                                             
TURN     3  T3 ASP A  49  ALA A  51                                             
TURN     4  T4 GLN A  58  GLU A  59                                             
TURN     5  T5 LEU A  67  GLY A  71                                             
TURN     6  T6 PRO A  76  THR A  79                                             
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1           1          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      1.000000  0.000000  0.000000        0.00000                         
SCALE2      0.000000  1.000000  0.000000        0.00000                         
SCALE3      0.000000  0.000000  1.000000        0.00000