Structural Classification of Proteins

Family: Tyrosine-dependent oxidoreductases

: also known as short-chain dehydrogenases and SDR family
parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

Lineage:

Root: scop
Class: Alpha and beta proteins (a/b) [51349]
Mainly parallel beta sheets (beta-alpha-beta units)
Fold: NAD(P)-binding Rossmann-fold domains [51734]
core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
The nucleotide-binding modes of this and the next two folds/superfamilies are similar
Superfamily: NAD(P)-binding Rossmann-fold domains [51735]
uperfamily
Family: Tyrosine-dependent oxidoreductases [51751]
also known as short-chain dehydrogenases and SDR family
parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

Protein Domains:

Uridine diphosphogalactose-4-epimerase (UDP-galactose 4-epimerase) [51752]
1. Escherichia coli [TaxId: 562] [51753] (17)
  1. 1udc
    complexed with edo, na, nad, pig, ufm
    1. chain a [29785]
  2. 1udb
    complexed with edo, na, nad, peg, ufg
    1. chain a [29787]
  3. 1xel
    complexed with edo, na, nad, peg, upg
    1. chain a [29786]
  4. 1lrk
    complexed with na, nad, pge, ud1; mutant
    1. chain a [74225]
  5. 1nah
    complexed with edo, na, nad, peg, udp
    1. chain a [29788]
  6. 1a9y
    complexed with na, nad, upg; mutant
    1. chain a [29789]
  7. 1kvr
    complexed with edo, na, nad, peg, udp; mutant
    1. chain a [29793]
  8. 2udp
    complexed with edo, na, nad, upp
    1. chain a [29791]
    2. chain b [29792]
  9. 1uda
    complexed with edo, na, nad, pig, ufg
    1. chain a [29790]
  10. 1lrl
    complexed with na, nad, pge, upg; mutant
    1. chain a [74226]
  11. 1kvu
    complexed with edo, na, nad, peg, upg; mutant
    1. chain a [29794]
  12. 1a9z
    complexed with na, nad, pge, upg; mutant
    1. chain a [29795]
  13. 1lrj
    complexed with na, nad, pge, ud1
    1. chain a [74224]
  14. 1nai
    complexed with na, nad, pdo, peg, udp
    1. chain a [29796]
  15. 1kvq
    complexed with edo, na, nad, upg; mutant
    1. chain a [29797]
  16. 1kvt
    complexed with na, nad, peg, upg; mutant
    1. chain a [29798]
  17. 1kvs
    complexed with na, nad, peg, upg; mutant
    1. chain a [29799]
2. Human (Homo sapiens) [TaxId: 9606] [51754] (7)
  1. 1ek6
    complexed with mg, nai, tma, upg
    1. chain a [29800]
    2. chain b [29801]
  2. 1i3k
    complexed with cl, egl, mg, nad, upg; mutant
    1. chain a [61595]
    2. chain b [61596]
  3. 1i3l
    complexed with cl, egl, gdu, mg, nad; mutant
    1. chain a [61597]
    2. chain b [61598]
  4. 1i3n
    complexed with cl, mg, nad, ud1, ud2; mutant
    1. chain a [61601]
    2. chain b [61602]
  5. 1i3m
    complexed with cl, mg, nad, ud1; mutant
    1. chain a [61599]
    2. chain b [61600]
  6. 1hzj
    complexed with cl, mg, nad, ud1
    1. chain a [61450]
    2. chain b [61451]
  7. 1ek5
    complexed with nad
    1. chain a [29802]
3. Trypanosoma brucei [TaxId: 5691] [89519] (5)
  1. 1gy8
    complexed with nad, udp
    1. chain a [83376]
    2. chain b [83377]
    3. chain c [83378]
    4. chain d [83379]
  2. 2cnb
    automatically matched to d1gy8a_
    complexed with nad, ufg
    1. region a:-1-381 [130636]
  3. 2cnb
    automatically matched to d1gy8a_
    complexed with nad, ufg
    1. region b:-1-381 [130637]
  4. 2cnb
    automatically matched to d1gy8a_
    complexed with nad, ufg
    1. region c:-1-381 [130638]
  5. 2cnb
    automatically matched to d1gy8a_
    complexed with nad, ufg
    1. region d:-1-381 [130639]
4. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [141872] (1)
  SQ P04397 11-357
  N-terminal domain of bifunctional Gal10 protein
  1. 1z45
    complexed with gal, gud, na, nad; mutant
    1. region a:11-357 [124428]
dTDP-glucose 4,6-dehydratase (RmlB) [51755]
1. Escherichia coli [TaxId: 562] [51756] (1)
  1. 1bxk
    complexed with nad
    1. chain a [29803]
    2. chain b [29804]
2. Salmonella enterica [TaxId: 28901] [63925] (1)
  1. 1g1a
    complexed with nad, so4
    1. chain a [60198]
    2. chain b [60199]
    3. chain c [60200]
    4. chain d [60201]
3. Streptococcus suis, serotype 2 [TaxId: 1307] [69406] (6)
  1. 1oc2
    complexed with nah, so4, tdx
    1. chain a [92765]
    2. chain b [92766]
  2. 1kep
    complexed with nad, so4, tdx
    1. chain a [68536]
    2. chain b [68537]
  3. 1ket
    complexed with nad, tyd
    1. chain a [68540]
    2. chain b [68541]
  4. 1kew
    complexed with gol, nad, tyd
    1. chain a [68544]
    2. chain b [68545]
  5. 1ker
    complexed with dau, nad, so4
    1. chain a [68538]
    2. chain b [68539]
  6. 1keu
    complexed with dau, nad
    1. chain a [68542]
    2. chain b [68543]
4. Streptomyces venezuelae [TaxId: 54571] [102133] (2)
  1. 1r6d
    complexed with dau, nad; mutant
    1. chain a [97148]
  2. 1r66
    complexed with cl, nad, tyd
    1. chain a [97146]
dTDP-6-deoxy-L-lyxo-4-hexulose reductase (RmlD) [75102]
1. Salmonella enterica serovar typhimurium [TaxId: 90371] [75103] (4)
  1. 1n2s
    complexed with mg, nah, trs
    1. chain a [79857]
  2. 1kbz
    complexed with mg
    1. chain a [72288]
  3. 1kc1
    complexed with mg, ndp, so4
    1. chain a [72290]
  4. 1kc3
    complexed with mg, ndp, trh
    1. chain a [72292]
GDP-4-keto-6-deoxy-d-mannose epimerase/reductase (GDP-fucose synthetase) [51757]
1. Escherichia coli [TaxId: 562] [51758] (8)
  1. 1e6u
    complexed with nap, so4, trs, uvw
    1. chain a [29805]
  2. 1e7s
    complexed with nap, so4, trs, uvw; mutant
    1. chain a [29806]
  3. 1e7q
    complexed with nap, so4, trs, uvw; mutant
    1. chain a [29807]
  4. 1e7r
    complexed with nap, so4, trs, uvw; mutant
    1. chain a [29808]
  5. 1bsv
    complexed with ndp
    1. chain a [29809]
  6. 1fxs
    complexed with nap
    1. chain a [29810]
  7. 1gfs
    1. chain a [29811]
  8. 1bws
    complexed with ndp
    1. chain a [29812]
GDP-mannose 4,6-dehydratase [51759]
1. Escherichia coli [TaxId: 562] [51760] (1)
  1. 1db3
    1. chain a [29813]
2. Pseudomonas aeruginosa [TaxId: 287] [102134] (1)
  1. 1rpn
    complexed with gdp, ndp
    1. chain a [97708]
    2. chain b [97709]
    3. chain c [97710]
    4. chain d [97711]
3. Human (Homo sapiens) [TaxId: 9606] [102135] (1)
  1. 1t2a
    complexed with gdp, ndp
    1. chain a [99078]
    2. chain b [99079]
    3. chain c [99080]
    4. chain d [99081]
4. Thale-cress (Arabidopsis thaliana) [TaxId: 3702] [82289] (2)
  1. 1n7h
    complexed with gdp, ndp
    1. chain a [80250]
    2. chain b [80251]
  2. 1n7g
    complexed with gdr, ndp
    1. chain a [80246]
    2. chain b [80247]
    3. chain c [80248]
    4. chain d [80249]
ADP-L-glycero-D-mannoheptose 6-epimerase [51761]
1. Escherichia coli [TaxId: 562] [51762] (1)
  1. 1eq2
    complexed with adq, nap
    1. chain a [29814]
    2. chain b [29815]
    3. chain c [29816]
    4. chain d [29817]
    5. chain e [29818]
    6. chain f [29819]
    7. chain g [29820]
    8. chain h [29821]
    9. chain i [29822]
    10. chain j [29823]
CDP-glucose-4,6-dehydratase [102136]
1. Yersinia pseudotuberculosis [TaxId: 633] [102137] (1)
  1. 1rkx
    complexed with nad
    1. chain a [97631]
    2. chain b [97632]
    3. chain c [97633]
    4. chain d [97634]
2. Salmonella typhimurium [TaxId: 90371] [141873] (2)
  SQ P26397 2-356
  1. 1wvg
    complexed with apr, cxy
    1. region a:4-358 [121339]
  2. 1wvg
    automatically matched to 1WVG A:4-358
    complexed with apr, cxy
    1. region b:1004-1357 [121340]
CDP-tyvelose-2-epimerase [102138]
1. Salmonella typhi [TaxId: 90370] [102139] (1)
  1. 1orr
    complexed with cdp, nad
    1. chain a [93460]
    2. chain b [93461]
    3. chain c [93462]
    4. chain d [93463]
Phenylcoumaran benzylic ether reductase [102140]
1. Loblolly pine (Pinus taeda) [TaxId: 3352] [102141] (1)
  1. 1qyc
    1. chain a [96581]
    2. chain b [96582]
Pinoresinol-lariciresinol reductase [102142]
1. Giant arborvitae (Thuja plicata) [TaxId: 3316] [102143] (1)
  1. 1qyd
    1. chain a [96583]
    2. chain b [96584]
    3. chain c [96585]
    4. chain d [96586]
Sulfolipid biosynthesis protein SQD1 [51763]
1. Thale cress (Arabidopsis thaliana) [TaxId: 3702] [51764] (4)
  1. 1i24
    complexed with nad, so4, upg
    1. chain a [83663]
  2. 1i2c
    complexed with nad, so4, upg; mutant
    1. chain a [83666]
  3. 1qrr
    1. chain a [29824]
  4. 1i2b
    complexed with nad, so4, upg, usq; mutant
    1. chain a [83665]
Negative transcriptional regulator NmrA [69407]
has an UDP-galactose 4-epimerase-like structure but evolved a different function
1. Aspergillus nidulans [TaxId: 162425] [69408] (29)
  SQ O59919
  1. 1xgk
    complexed with cl, gol, k, po4; mutant
    1. chain a [115286]
  2. 1k6x
    complexed with cl, nad
    1. chain a [68238]
  3. 1ti7
    complexed with cl, gol, k, nap
    1. chain a [106998]
  4. 1k6j
    complexed with cl
    1. chain a [68224]
    2. chain b [68225]
  5. 1k6i
    complexed with cl
    1. chain a [68223]
  6. 2vut
    automatically matched to d1k6jb_
    complexed with cl, gol, nad, zn
    1. region a:3-352 [153573]
  7. 2vut
    automatically matched to d1k6jb_
    complexed with cl, gol, nad, zn
    1. region b:3-352 [153574]
  8. 2vut
    automatically matched to d1k6jb_
    complexed with cl, gol, nad, zn
    1. region c:3-352 [153575]
  9. 2vut
    automatically matched to d1k6jb_
    complexed with cl, gol, nad, zn
    1. region d:3-352 [153576]
  10. 2vut
    automatically matched to d1k6jb_
    complexed with cl, gol, nad, zn
    1. region e:3-352 [153577]
  11. 2vut
    automatically matched to d1k6jb_
    complexed with cl, gol, nad, zn
    1. region f:3-352 [153578]
  12. 2vut
    automatically matched to d1k6jb_
    complexed with cl, gol, nad, zn
    1. region g:3-352 [153579]
  13. 2vut
    automatically matched to d1k6jb_
    complexed with cl, gol, nad, zn
    1. region h:3-352 [153580]
  14. 2vus
    automatically matched to d1k6jb_
    complexed with cl, so4, zn
    1. region a:3-352 [153557]
  15. 2vus
    automatically matched to d1k6jb_
    complexed with cl, so4, zn
    1. region b:3-352 [153558]
  16. 2vus
    automatically matched to d1k6jb_
    complexed with cl, so4, zn
    1. region c:3-352 [153559]
  17. 2vus
    automatically matched to d1k6jb_
    complexed with cl, so4, zn
    1. region d:3-352 [153560]
  18. 2vus
    automatically matched to d1k6jb_
    complexed with cl, so4, zn
    1. region e:3-352 [153561]
  19. 2vus
    automatically matched to d1k6jb_
    complexed with cl, so4, zn
    1. region f:3-352 [153562]
  20. 2vus
    automatically matched to d1k6jb_
    complexed with cl, so4, zn
    1. region g:3-352 [153563]
  21. 2vus
    automatically matched to d1k6jb_
    complexed with cl, so4, zn
    1. region h:3-352 [153564]
  22. 2vuu
    automatically matched to d1k6jb_
    complexed with nap, zn
    1. region a:3-352 [153589]
  23. 2vuu
    automatically matched to d1k6jb_
    complexed with nap, zn
    1. region b:3-352 [153590]
  24. 2vuu
    automatically matched to d1k6jb_
    complexed with nap, zn
    1. region c:3-352 [153591]
  25. 2vuu
    automatically matched to d1k6jb_
    complexed with nap, zn
    1. region d:3-352 [153592]
  26. 2vuu
    automatically matched to d1k6jb_
    complexed with nap, zn
    1. region e:3-352 [153593]
  27. 2vuu
    automatically matched to d1k6jb_
    complexed with nap, zn
    1. region f:3-352 [153594]
  28. 2vuu
    automatically matched to d1k6jb_
    complexed with nap, zn
    1. region g:3-352 [153595]
  29. 2vuu
    automatically matched to d1k6jb_
    complexed with nap, zn
    1. region h:3-352 [153596]
Carbonyl reductase [51765]
1. Mouse (Mus musculus) [TaxId: 10090] [51766] (1)
  1. 1cyd
    complexed with ipa, nap
    1. chain a [29825]
    2. chain b [29826]
    3. chain c [29827]
    4. chain d [29828]
2. Human (Homo sapiens) [TaxId: 9606] [102144] (5)
  dicarbonyl/L-xylulose reductase
  1. 1pr9
    complexed with 2hp, k, nap
    1. chain a [95060]
    2. chain b [95061]
  2. 1wnt
    automatically matched to d1pr9a_
    complexed with nap
    1. region a:1-244 [121102]
  3. 1wnt
    automatically matched to d1pr9a_
    complexed with nap
    1. region b:1-244 [121103]
  4. 1wnt
    automatically matched to d1pr9a_
    complexed with nap
    1. region c:1-244 [121104]
  5. 1wnt
    automatically matched to d1pr9a_
    complexed with nap
    1. region d:1-244 [121105]
Sepiapterin reductase [51767]
1. Mouse (Mus musculus) [TaxId: 10090] [51768] (3)
  1. 1oaa
    complexed with nap, oaa, so4
    1. chain a [29829]
  2. 1sep
    complexed with bio, nap
    1. chain a [29830]
  3. 1nas
    complexed with ase, nap, oaa
    1. chain a [29831]
2. Human (Homo sapiens) [TaxId: 9606] [141874] (6)
  SQ P35270 5-261
  1. 1z6z
    complexed with cl, nap, so4
    1. region a:2-258 [124575]
  2. 1z6z
    automatically matched to 1Z6Z A:2-258
    complexed with cl, nap, so4
    1. region b:2-258 [124576]
  3. 1z6z
    automatically matched to 1Z6Z A:2-258
    complexed with cl, nap, so4
    1. region c:2-258 [124577]
  4. 1z6z
    automatically matched to 1Z6Z A:2-258
    complexed with cl, nap, so4
    1. region d:2-258 [124578]
  5. 1z6z
    automatically matched to 1Z6Z A:2-258
    complexed with cl, nap, so4
    1. region e:2-258 [124579]
  6. 1z6z
    automatically matched to 1Z6Z A:2-258
    complexed with cl, nap, so4
    1. region f:2-258 [124580]
Dihydropteridin reductase (pteridine reductase) [51769]
1. Rat (Rattus norvegicus) [TaxId: 10116] [51770] (2)
  1. 1dhr
    complexed with nad
    1. chain a [29832]
  2. 1dir
    complexed with nad
    1. chain a [29833]
    2. chain b [29834]
    3. chain c [29835]
    4. chain d [29836]
2. Human (Homo sapiens) [TaxId: 9606] [51771] (1)
  1. 1hdr
    complexed with nad
    1. chain a [29837]
3. Leishmania major [TaxId: 5664] [63926] (35)
  SQ Q01782
  1. 1e7w
    complexed with edo, mtx, ndp
    1. chain a [59373]
    2. chain b [59374]
  2. 1e92
    complexed with edo, hbi, nap
    1. chain a [64798]
    2. chain b [64799]
    3. chain c [64800]
    4. chain d [64801]
  3. 2qhx
    automatically matched to d1e7wa_
    complexed with fe1, iod, nap
    1. region a:5-288 [150796]
  4. 2qhx
    automatically matched to d1e7wa_
    complexed with fe1, iod, nap
    1. region b:5-288 [150797]
  5. 2qhx
    automatically matched to d1e7wa_
    complexed with fe1, iod, nap
    1. region c:6-288 [150798]
  6. 2qhx
    automatically matched to d1e7wa_
    complexed with fe1, iod, nap
    1. region d:5-288 [150799]
  7. 2bf7
    automatically matched to d1e7wa_
    complexed with edo, hbi, nap
    1. region a:6-288 [128407]
  8. 2bf7
    automatically matched to d1e7wa_
    complexed with edo, hbi, nap
    1. region b:6-288 [128408]
  9. 2bf7
    automatically matched to d1e7wa_
    complexed with edo, hbi, nap
    1. region c:6-288 [128409]
  10. 2bf7
    automatically matched to d1e7wa_
    complexed with edo, hbi, nap
    1. region d:6-288 [128410]
  11. 2bfp
    automatically matched to d1e7wa_
    complexed with edo, h4b, nap
    1. region a:6-288 [128448]
  12. 2bfp
    automatically matched to d1e7wa_
    complexed with edo, h4b, nap
    1. region b:6-288 [128449]
  13. 2bfp
    automatically matched to d1e7wa_
    complexed with edo, h4b, nap
    1. region c:6-288 [128450]
  14. 2bfp
    automatically matched to d1e7wa_
    complexed with edo, h4b, nap
    1. region d:6-288 [128451]
  15. 2bfo
    automatically matched to d1e7wa_
    complexed with edo, ndp
    1. region a:6-288 [128444]
  16. 2bfo
    automatically matched to d1e7wa_
    complexed with edo, ndp
    1. region b:6-288 [128445]
  17. 2bfo
    automatically matched to d1e7wa_
    complexed with edo, ndp
    1. region c:6-288 [128446]
  18. 2bfo
    automatically matched to d1e7wa_
    complexed with edo, ndp
    1. region d:6-288 [128447]
  19. 2bfa
    automatically matched to d1e7wa_
    complexed with cb3, edo, ndp
    1. region a:6-288 [128413]
  20. 2bfa
    automatically matched to d1e7wa_
    complexed with cb3, edo, ndp
    1. region b:6-288 [128414]
  21. 2bfa
    automatically matched to d1e7wa_
    complexed with cb3, edo, ndp
    1. region c:6-288 [128415]
  22. 2bfa
    automatically matched to d1e7wa_
    complexed with cb3, edo, ndp
    1. region d:6-288 [128416]
  23. 2bfm
    automatically matched to d1e7wa_
    complexed with ndp, top
    1. region a:6-288 [128439]
  24. 2bfm
    automatically matched to d1e7wa_
    complexed with ndp, top
    1. region b:6-288 [128440]
  25. 2bfm
    automatically matched to d1e7wa_
    complexed with ndp, top
    1. region c:6-288 [128441]
  26. 2bfm
    automatically matched to d1e7wa_
    complexed with ndp, top
    1. region d:6-288 [128442]
  27. 1w0c
    complexed with nap, taq
    1. chain a [114052]
    2. chain b [114053]
    3. chain c [114054]
    4. chain d [114055]
    5. chain e [114056]
    6. chain f [114057]
    7. chain g [114058]
    8. chain h [114059]
  28. 2p8k
    automatically matched to d1e7wa_
    complexed with dyp, nap
    1. region a:5-288 [149305]
  29. 2p8k
    automatically matched to d1e7wa_
    complexed with dyp, nap
    1. region b:5-288 [149306]
  30. 2p8k
    automatically matched to d1e7wa_
    complexed with dyp, nap
    1. region c:6-288 [149307]
  31. 2p8k
    automatically matched to d1e7wa_
    complexed with dyp, nap
    1. region d:5-288 [149308]
  32. 2p8k
    automatically matched to d1e7wa_
    complexed with dyp, nap
    1. region e:6-288 [149309]
  33. 2p8k
    automatically matched to d1e7wa_
    complexed with dyp, nap
    1. region f:5-288 [149310]
  34. 2p8k
    automatically matched to d1e7wa_
    complexed with dyp, nap
    1. region g:6-288 [149311]
  35. 2p8k
    automatically matched to d1e7wa_
    complexed with dyp, nap
    1. region h:5-288 [149312]
4. Leishmania tarentolae [TaxId: 5689] [102145] (1)
  1. 1p33
    complexed with mtx, ndp
    1. chain a [93966]
    2. chain b [93967]
    3. chain c [93968]
    4. chain d [93969]
5. Trypanosoma cruzi [TaxId: 5693] [102146] (2)
  1. 1mxh
    complexed with dhf, nap
    1. chain a [91490]
    2. chain b [91491]
    3. chain c [91492]
    4. chain d [91493]
  2. 1mxf
    complexed with mtx, ndp
    1. chain a [91486]
    2. chain b [91487]
    3. chain c [91488]
    4. chain d [91489]
6. Nematode (Caenorhabditis elegans) [TaxId: 6239] [89520] (1)
  1. 1ooe
    structural genomics
    complexed with mes
    1. chain a [87196]
    2. chain b [87197]
Human estrogenic 17beta-hydroxysteroid dehydrogenase [51772]
1. Human (Homo sapiens) [TaxId: 9606] [51773] (16)
  SQ P14061
  1. 1jtv
    complexed with gol, tes
    1. chain a [84230]
  2. 1i5r
    complexed with gol, hyc
    1. chain a [83668]
  3. 1qyw
    complexed with 5sd, gol, nap
    1. chain a [104660]
  4. 1fds
    complexed with est
    1. chain a [29838]
  5. 1qyv
    complexed with gol, nap
    1. chain a [104659]
  6. 1qyx
    complexed with asd, gol, nap
    1. chain a [104661]
  7. 1a27
    complexed with est, nap; mutant
    1. chain a [29839]
  8. 1bhs
    1. chain a [29840]
  9. 1fdt
    complexed with est, nap, so4
    1. chain a [29841]
  10. 1iol
    complexed with est
    1. chain a [29842]
  11. 1dht
    complexed with dht
    1. chain a [29843]
  12. 3dhe
    complexed with and
    1. chain a [29844]
  13. 1fdw
    complexed with est; mutant
    1. chain a [29845]
  14. 1equ
    complexed with equ, ndp
    1. chain a [29846]
    2. chain b [29847]
  15. 1fdu
    complexed with est, nap, so4; mutant
    1. chain a [29848]
    2. chain b [29849]
    3. chain c [29850]
    4. chain d [29851]
  16. 1fdv
    complexed with nad, so4; mutant
    1. chain a [29852]
    2. chain b [29853]
    3. chain c [29854]
    4. chain d [29855]
7-alpha-hydroxysteroid dehydrogenase [51774]
1. Escherichia coli [TaxId: 562] [51775] (3)
  1. 1fmc
    complexed with cho, nad
    1. chain a [29856]
    2. chain b [29857]
  2. 1ahi
    complexed with cho, nad
    1. chain a [29858]
    2. chain b [29859]
  3. 1ahh
    complexed with nad
    1. chain a [29860]
    2. chain b [29861]
3-alpha,20-beta-hydroxysteroid dehydrogenase [51776]
1. Streptomyces hydrogenans [TaxId: 1905] [51777] (2)
  1. 1hdc
    complexed with cbo
    1. chain a [29862]
    2. chain b [29863]
    3. chain c [29864]
    4. chain d [29865]
  2. 2hsd
    complexed with nad
    1. chain a [29866]
    2. chain b [29867]
    3. chain c [29868]
    4. chain d [29869]
3-alpha-hydroxysteroid dehydrogenase [51778]
1. Comamonas testosteroni [TaxId: 285] [51779] (2)
  1. 1fjh
    1. chain a [29870]
    2. chain b [29871]
  2. 1fk8
    complexed with nad
    1. chain a [29872]
    2. chain b [29873]
3beta/17beta hydroxysteroid dehydrogenase [82290]
1. Comamonas testosteroni [TaxId: 285] [82291] (1)
  1. 1hxh
    1. chain a [76725]
    2. chain b [76726]
    3. chain c [76727]
    4. chain d [76728]
Putative oxidoreductase Rv2002 [82292]
1. Mycobacterium tuberculosis [TaxId: 1773] [82293] (3)
  1. 1nff
    structural genomics
    complexed with nad; mutant
    1. chain a [80457]
    2. chain b [80458]
  2. 1nfr
    complexed with mse, nad; mutant
    1. chain a [80463]
    2. chain b [80464]
    3. chain c [80465]
    4. chain d [80466]
  3. 1nfq
    complexed with ae2, nai; mutant
    1. chain a [80459]
    2. chain b [80460]
    3. chain c [80461]
    4. chain d [80462]
R-specific alcohol dehydrogenase [89521]
1. Lactobacillus brevis [TaxId: 1580] [89522] (15)
  1. 1zk4
    automatically matched to d1nxqa_
    complexed with ac0, mg, nap
    1. region a:1-251 [125176]
  2. 1zjy
    complexed with mg, nai, ss2; mutant
    1. region a:1-251 [125163]
  3. 1zjz
    automatically matched to 1ZJY A:1-251
    complexed with mg, nad, ss2; mutant
    1. region a:1-251 [125164]
  4. 1zk2
    automatically matched to 1ZJY A:1-251
    complexed with mg; mutant
    1. region a:1-251 [125167]
  5. 1zk0
    automatically matched to 1ZJY A:1-251
    complexed with mg, nai, ss2; mutant
    1. region a:1-251 [125165]
  6. 1nxq
    complexed with mg
    1. chain a [86388]
  7. 1zk1
    automatically matched to 1ZJY A:1-251
    complexed with ac0, mg, nad; mutant
    1. region a:1-251 [125166]
  8. 1zk3
    automatically matched to 1ZJY A:1-251
    complexed with mg; mutant
    1. region a:1-251 [125168]
  9. 1zk3
    automatically matched to 1ZJY A:1-251
    complexed with mg; mutant
    1. region b:1-251 [125169]
  10. 1zk3
    automatically matched to 1ZJY A:1-251
    complexed with mg; mutant
    1. region c:1-251 [125170]
  11. 1zk3
    automatically matched to 1ZJY A:1-251
    complexed with mg; mutant
    1. region d:1-251 [125171]
  12. 1zk3
    automatically matched to 1ZJY A:1-251
    complexed with mg; mutant
    1. region e:1-251 [125172]
  13. 1zk3
    automatically matched to 1ZJY A:1-251
    complexed with mg; mutant
    1. region f:1-251 [125173]
  14. 1zk3
    automatically matched to 1ZJY A:1-251
    complexed with mg; mutant
    1. region g:1-251 [125174]
  15. 1zk3
    automatically matched to 1ZJY A:1-251
    complexed with mg; mutant
    1. region h:1-251 [125175]
Cis-biphenyl-2,3-dihydrodiol-2,3-dehydrogenase [51780]
1. Pseudomonas sp., lb400 [TaxId: 306] [51781] (1)
  1. 1bdb
    complexed with nad
    1. chain a [29874]
Drosophila alcohol dehydrogenase [51782]
1. Fruit fly (Drosophila melanogaster) [TaxId: 7227] [102147] (1)
  1. 1mg5
    complexed with act, nah
    1. chain a [91264]
    2. chain b [91265]
2. Fly (Drosophila lebanonensis) [TaxId: 7225] [51783] (7)
  1. 1sby
    automatically matched to d1a4ua_
    complexed with etf, nad
    1. region a:1-254 [118930]
  2. 1sby
    automatically matched to d1a4ua_
    complexed with etf, nad
    1. region b:1-254 [118931]
  3. 1b16
    1. chain a [29875]
    2. chain b [29876]
  4. 1b2l
    1. chain a [29877]
  5. 1a4u
    1. chain a [29878]
    2. chain b [29879]
  6. 1b15
    1. chain a [29880]
    2. chain b [29881]
  7. 1b14
    1. chain a [29882]
    2. chain b [29883]
Glucose dehydrogenase [51784]
1. Bacillus megaterium [TaxId: 1404] [51785] (4)
  1. 1gee
    complexed with nad; mutant
    1. chain a [90509]
    2. chain b [90510]
    3. chain e [90511]
    4. chain f [90512]
  2. 1gco
    complexed with nad
    1. chain a [29884]
    2. chain b [29885]
    3. chain e [29886]
    4. chain f [29887]
  3. 1g6k
    complexed with nad; mutant
    1. chain a [90502]
    2. chain b [90503]
    3. chain e [90504]
    4. chain f [90505]
  4. 1rwb
    complexed with nad; mutant
    1. chain a [97970]
    2. chain b [97971]
    3. chain e [97972]
    4. chain f [97973]
Sorbitol dehydrogenase [102148]
1. Rhodobacter sphaeroides [TaxId: 1063] [102149] (1)
  1. 1k2w
    1. chain a [90927]
    2. chain b [90928]
meso-2,3-butanediol dehydrogenase [51786]
1. Klebsiella pneumoniae [TaxId: 573] [51787] (1)
  1. 1geg
    complexed with bme, glc, mg, nad
    1. chain a [29888]
    2. chain b [29889]
    3. chain c [29890]
    4. chain d [29891]
    5. chain e [29892]
    6. chain f [29893]
    7. chain g [29894]
    8. chain h [29895]
Levodione reductase [89523]
1. Corynebacterium aquaticum [TaxId: 144185] [89524] (1)
  1. 1iy8
    complexed with mpd, nad
    1. chain a [83774]
    2. chain b [83775]
    3. chain c [83776]
    4. chain d [83777]
    5. chain e [83778]
    6. chain f [83779]
    7. chain g [83780]
    8. chain h [83781]
Mannitol dehydrogenase [63927]
1. Mushroom (Agaricus bisporus) [TaxId: 5341] [63928] (1)
  1. 1h5q
    complexed with nap, ni
    1. chain a [60643]
    2. chain b [60644]
    3. chain c [60645]
    4. chain d [60646]
    5. chain e [60647]
    6. chain f [60648]
    7. chain g [60649]
    8. chain h [60650]
    9. chain i [60651]
    10. chain j [60652]
    11. chain k [60653]
    12. chain l [60654]
(3R)-hydroxyacyl-CoA dehydrogenase domain of estradiol 17 beta-Dehydrogenase 4 [82294]
peroxisomal multifunctional enzyme type 2
segment swapping involving a C-terminal extension to the family fold
1. Rat (Rattus norvegicus) [TaxId: 10116] [82295] (1)
  1. 1gz6
    complexed with mse, nai, so4
    1. chain a [76410]
    2. chain b [76411]
    3. chain c [76412]
    4. chain d [76413]
beta-keto acyl carrier protein reductase [51788]
1. Oil seed rape (Brassica napus) [TaxId: 3708] [51789] (7)
  1. 1edo
    complexed with nap
    1. chain a [29896]
  2. 2cdh
    automatically matched to d1edoa_
    1. region g:17-260 [130282]
  3. 2cdh
    automatically matched to d1edoa_
    1. region h:17-260 [130283]
  4. 2cdh
    automatically matched to d1edoa_
    1. region i:17-260 [130284]
  5. 2cdh
    automatically matched to d1edoa_
    1. region j:17-260 [130285]
  6. 2cdh
    automatically matched to d1edoa_
    1. region k:17-260 [130286]
  7. 2cdh
    automatically matched to d1edoa_
    1. region l:17-260 [130287]
2. Escherichia coli [TaxId: 562] [51790] (3)
  1. 1q7b
    complexed with ca, nap
    1. chain a [96026]
    2. chain b [96027]
    3. chain c [96028]
    4. chain d [96029]
  2. 1q7c
    complexed with nap; mutant
    1. chain a [96030]
    2. chain b [96031]
  3. 1i01
    1. chain a [29897]
    2. chain b [29898]
    3. chain c [29899]
    4. chain d [29900]
    5. chain e [29901]
    6. chain f [29902]
    7. chain g [29903]
    8. chain h [29904]
3. Thermotoga maritima [TaxId: 2336] [102150] (1)
  TM1169
  1. 1o5i
    structural genomics
    complexed with nad
    1. chain a [92499]
    2. chain b [92500]
    3. chain c [92501]
    4. chain d [92502]
4. Thermus thermophilus [TaxId: 274] [117407] (1)
  SQ Q5SK98
  1. 1uls
    Structural genomics target
    mutant
    1. chain a [113284]
    2. chain b [113285]
    3. chain c [113286]
    4. chain d [113287]
    5. chain e [113288]
    6. chain f [113289]
    7. chain g [113290]
    8. chain h [113291]
5. Streptomyces coelicolor [TaxId: 1902] [117408] (9)
  SQ P16544 #SP
  1. 2rhc
    automatically matched to d1w4zb_
    complexed with emo, nap
    1. region a:5-261 [152048]
  2. 2rhc
    automatically matched to d1w4zb_
    complexed with emo, nap
    1. region b:5-261 [152049]
  3. 2rh4
    automatically matched to d1w4zb_
    complexed with emo, nap
    1. region a:5-261 [152028]
  4. 2rh4
    automatically matched to d1w4zb_
    complexed with emo, nap
    1. region b:5-261 [152029]
  5. 1x7g
    complexed with nap
    1. chain a [114929]
    2. chain b [114930]
  6. 1x7h
    complexed with nap
    1. chain a [114931]
    2. chain b [114932]
  7. 1w4z
    complexed with fmt, nap
    1. chain a [114195]
    2. chain b [114196]
  8. 1xr3
    complexed with isz, nap
    1. region a:6-261 [122245]
  9. 1xr3
    automatically matched to 1XR3 A:6-261
    complexed with isz, nap
    1. region b:6-261 [122246]
6. Mycobacterium tuberculosis [TaxId: 1773] [141875] (6)
  SQ P0A5Y4 9-245! SQ P0A5Y4 9-247
  1. 1uzm
    complexed with cs; mutant
    1. region a:9-245 [119811]
  2. 1uzm
    automatically matched to 1UZM A:9-245
    complexed with cs; mutant
    1. region b:9-245 [119812]
  3. 1uzn
    automatically matched to 1UZM A:9-245
    complexed with cs, nap; mutant
    1. region a:9-245 [119813]
  4. 1uzn
    automatically matched to 1UZM A:9-245
    complexed with cs, nap; mutant
    1. region b:9-245 [119814]
  5. 1uzl
    complexed with cs
    1. region a:9-247 [119809]
  6. 1uzl
    automatically matched to 1UZL A:9-247
    complexed with cs
    1. region b:9-247 [119810]
7. Thermus thermophilus, TTHB020 [TaxId: 274] [141876] (2)
  SQ Q53WH2 2-242
  1. 2a4k
    1. region a:2-242 [126156]
  2. 2a4k
    automatically matched to 2A4K A:2-242
    1. region b:3-242 [126157]
8. Malaria parasite (Plasmodium falciparum) [TaxId: 5833] [141877] (1)
  SQ Q86RB1 54-304
  1. 2c07
    complexed with so4
    1. region a:54-304 [129577]
Enoyl-ACP reductase [51791]
1. Oil seed rape (Brassica napus) [TaxId: 3708] [51792] (4)
  1. 1d7o
    1. chain a [29907]
  2. 1eno
    complexed with nad; mutant
    1. chain a [29905]
  3. 1enp
    complexed with nah; mutant
    1. chain a [29906]
  4. 1cwu
    complexed with nad, tdb; mutant
    1. chain a [29908]
    2. chain b [29909]
2. Malaria parasite (Plasmodium falciparum) [TaxId: 5833] [82296] (27)
  SQ Q9BJJ9 96-424 # fragment
  1. 1uh5
    complexed with nad, tcl
    1. chain a [107840]
    2. chain b [107841]
  2. 2oos
    automatically matched to d1vrwa1
    complexed with jpj, nad
    1. region a:97-424 [148938]
  3. 2oos
    automatically matched to d1vrwa1
    complexed with jpj, nad
    1. region b:97-424 [148939]
  4. 2o2y
    automatically matched to 1VRW A:97-425
    complexed with cl, nad, so4, tcl
    1. region a:15-342 [138894]
  5. 2o2y
    automatically matched to 1VRW A:97-425
    complexed with cl, nad, so4, tcl
    1. region b:15-342 [138895]
  6. 2o2y
    automatically matched to 1VRW A:97-425
    complexed with cl, nad, so4, tcl
    1. region c:14-342 [138896]
  7. 2o2y
    automatically matched to 1VRW A:97-425
    complexed with cl, nad, so4, tcl
    1. region d:15-342 [138897]
  8. 1v35
    complexed with nai
    1. chain a [108301]
    2. chain b [108302]
  9. 1nhg
    complexed with nad, tcl
    1. chain a,c [80516]
    2. chain b,d [80517]
  10. 1nhw
    complexed with nad, tcc
    1. chain a,c [80518]
    2. chain b,d [80519]
  11. 1vrw
    complexed with nad
    1. region a:97-425 [120484]
  12. 1vrw
    automatically matched to 1VRW A:97-425
    complexed with nad
    1. region b:97-425 [120485]
  13. 2ol4
    automatically matched to d1vrwa1
    complexed with jpn, nad
    1. region a:97-424 [148811]
  14. 2ol4
    automatically matched to d1vrwa1
    complexed with jpn, nad
    1. region b:98-424 [148812]
  15. 1nnu
    complexed with nad, tct
    1. chain a,c [80672]
    2. chain b,d [80673]
  16. 2op1
    automatically matched to d1vrwa1
    complexed with 8pc, nad
    1. region a:97-424 [148952]
  17. 2op1
    automatically matched to d1vrwa1
    complexed with 8pc, nad
    1. region b:98-424 [148953]
  18. 2op0
    automatically matched to d1vrwa1
    complexed with 7pc, nad, so4
    1. region a:97-424 [148950]
  19. 2op0
    automatically matched to d1vrwa1
    complexed with 7pc, nad, so4
    1. region b:98-424 [148951]
  20. 1zxb
    automatically matched to 1VRW A:97-425
    complexed with nad, tn3
    1. region a:97-425 [125767]
  21. 1zxb
    automatically matched to 1VRW A:97-425
    complexed with nad, tn3
    1. region b:97-425 [125768]
  22. 1zsn
    automatically matched to 1VRW A:97-425
    complexed with nad, tn2
    1. region a:97-425 [125608]
  23. 1zsn
    automatically matched to 1VRW A:97-425
    complexed with nad, tn2
    1. region b:97-425 [125609]
  24. 1zw1
    automatically matched to 1VRW A:97-425
    complexed with nad, tn5
    1. region a:97-425 [125735]
  25. 1zw1
    automatically matched to 1VRW A:97-425
    complexed with nad, tn5
    1. region b:97-425 [125736]
  26. 1zxl
    automatically matched to 1VRW A:97-425
    complexed with jp1, nad
    1. region a:97-425 [125782]
  27. 1zxl
    automatically matched to 1VRW A:97-425
    complexed with jp1, nad
    1. region b:97-425 [125783]
3. Mycobacterium tuberculosis, TB, gene InhA [TaxId: 1773] [51793] (44)
  1. 2h7m
    automatically matched to d1bvra_
    complexed with 641, nad
    1. region a:2-269 [136219]
  2. 2h7i
    automatically matched to d1bvra_
    complexed with 566, nad
    1. region a:2-269 [136215]
  3. 2h7l
    automatically matched to d1bvra_
    complexed with 665, nad
    1. region a:2-269 [136218]
  4. 2h7n
    automatically matched to d1bvra_
    complexed with 744, nad
    1. region a:2-269 [136220]
  5. 2h7p
    automatically matched to d1bvra_
    complexed with 468, nad
    1. region a:2-269 [136221]
  6. 2aq8
    automatically matched to d1bvra_
    complexed with lys, nad
    1. region a:3-269 [127166]
  7. 2nv6
    automatically matched to d1enz__
    complexed with zid; mutant
    1. region a:3-269 [138627]
  8. 2idz
    automatically matched to d1bvra_
    complexed with zid
    1. region a:2-269 [147641]
  9. 2nsd
    automatically matched to d1bvra_
    complexed with 4pi, nad
    1. region a:2-269 [148384]
  10. 2nsd
    automatically matched to d1bvra_
    complexed with 4pi, nad
    1. region b:2-269 [148385]
  11. 2aqk
    automatically matched to d1enz__
    complexed with nad; mutant
    1. region a:3-269 [127181]
  12. 2ieb
    automatically matched to d1enza_
    complexed with zid; mutant
    1. region a:3-269 [147642]
  13. 2ied
    automatically matched to d1enza_
    mutant
    1. region a:3-269 [147643]
  14. 2ied
    automatically matched to d1enza_
    mutant
    1. region b:3-269 [147644]
  15. 2ied
    automatically matched to d1enza_
    mutant
    1. region c:3-269 [147645]
  16. 2ied
    automatically matched to d1enza_
    mutant
    1. region d:3-269 [147646]
  17. 2h9i
    automatically matched to d1bvra_
    complexed with ead
    1. region a:3-269 [136265]
  18. 2pr2
    automatically matched to d1bvra_
    complexed with dg1
    1. region a:3-269 [149796]
  19. 2ntj
    automatically matched to d1bvra_
    complexed with p1h; mutant
    1. region a:3-269 [138581]
  20. 2ntj
    automatically matched to d1bvra_
    complexed with p1h; mutant
    1. region b:3-269 [138582]
  21. 1eny
    complexed with nad
    1. chain a [29910]
  22. 2b37
    automatically matched to d1bvra_
    complexed with 8ps, nad
    1. region a:2-269 [127779]
  23. 2b37
    automatically matched to d1bvra_
    complexed with 8ps, nad
    1. region b:2-269 [127780]
  24. 2b37
    automatically matched to d1bvra_
    complexed with 8ps, nad
    1. region c:2-269 [127781]
  25. 2b37
    automatically matched to d1bvra_
    complexed with 8ps, nad
    1. region d:2-269 [127782]
  26. 2b37
    automatically matched to d1bvra_
    complexed with 8ps, nad
    1. region e:2-269 [127783]
  27. 2b37
    automatically matched to d1bvra_
    complexed with 8ps, nad
    1. region f:2-269 [127784]
  28. 1p44
    complexed with geq, nad
    1. chain a [94076]
    2. chain b [94077]
    3. chain c [94078]
    4. chain d [94079]
    5. chain e [94080]
    6. chain f [94081]
  29. 2b35
    automatically matched to d1bvra_
    complexed with nad, tcl
    1. region a:2-269 [127767]
  30. 2b35
    automatically matched to d1bvra_
    complexed with nad, tcl
    1. region b:2-269 [127768]
  31. 2b35
    automatically matched to d1bvra_
    complexed with nad, tcl
    1. region c:2-269 [127769]
  32. 2b35
    automatically matched to d1bvra_
    complexed with nad, tcl
    1. region d:2-269 [127770]
  33. 2b35
    automatically matched to d1bvra_
    complexed with nad, tcl
    1. region e:2-269 [127771]
  34. 2b35
    automatically matched to d1bvra_
    complexed with nad, tcl
    1. region f:2-269 [127772]
  35. 2b36
    automatically matched to d1bvra_
    complexed with 5pp, nad
    1. region a:2-269 [127773]
  36. 2b36
    automatically matched to d1bvra_
    complexed with 5pp, nad
    1. region b:2-269 [127774]
  37. 2b36
    automatically matched to d1bvra_
    complexed with 5pp, nad
    1. region c:2-269 [127775]
  38. 2b36
    automatically matched to d1bvra_
    complexed with 5pp, nad
    1. region d:2-269 [127776]
  39. 2b36
    automatically matched to d1bvra_
    complexed with 5pp, nad
    1. region e:2-269 [127777]
  40. 2b36
    automatically matched to d1bvra_
    complexed with 5pp, nad
    1. region f:2-269 [127778]
  41. 1zid
    complexed with zid; mutant
    1. chain a [29911]
  42. 1bvr
    complexed with nad, tht
    1. chain a [29913]
    2. chain b [29914]
    3. chain c [29915]
    4. chain d [29916]
    5. chain e [29917]
    6. chain f [29918]
  43. 1p45
    complexed with nad, tcl
    1. chain a [94082]
    2. chain b [94083]
  44. 1enz
    complexed with nad; mutant
    1. chain a [29912]
4. Escherichia coli [TaxId: 562] [51794] (14)
  1. 1qsg
    complexed with glc, nad, tcs
    1. chain a [29935]
    2. chain b [29936]
    3. chain c [29937]
    4. chain d [29938]
    5. chain e [29939]
    6. chain f [29940]
    7. chain g [29941]
    8. chain h [29942]
  2. 1qg6
    complexed with nad, tcl
    1. chain a [29919]