Fold: Ferredoxin-like

alpha+beta sandwich with antiparallel beta-sheet; (beta-alpha-beta)x2

Lineage:

1. Root: scop
2. Class: Alpha and beta proteins (a+b) [53931]
   Mainly antiparallel beta sheets (segregated alpha and beta regions)
3. Fold: Ferredoxin-like [54861]
   alpha+beta sandwich with antiparallel beta-sheet; (beta-alpha-beta)x2

Superfamilies:

1. 4Fe-4S ferredoxins [54862] (6)
2. Aspartate carbamoyltransferase, Regulatory-chain, N-terminal domain [54893] (1)
3. Protease propeptides/inhibitors [54897] (3)
4. Dimeric alpha+beta barrel [54909] (17)
   dimerizes through the beta-sheet; forms beta-sheet barrel, closed (n=8, S=12); dimers may assemble in higher oligomers
5. GlnB-like [54913] (4)
   form timeric structures with the orthogonally packed beta-sheets
6. SEA domain [82671] (1)
7. Nucleoside diphosphate kinase, NDK [54919] (1)
8. RNA-binding domain, RBD [54928] (4)
9. Viral DNA-binding domain [54957] (1)
10. RuBisCO, large subunit, small (N-terminal) domain [54966] (1)
    C-terminal domain is beta/alpha barrel
11. Acylphosphatase/BLUF domain-like [54975] (2)
12. EF-G C-terminal domain-like [54980] (3)
13. eEF-1beta-like [54984] (1)
14. eEF1-gamma domain [89942] (1)
    elaborated with additional structures
15. Anticodon-binding domain of PheRS [54991] (1)
16. Ribosomal protein S6 [54995] (1)
17. Ribosomal protein S10 [54999] (1)
18. N-utilization substance G protein NusG, N-terminal domain [82679] (1)
19. PAP/Archaeal CCA-adding enzyme, C-terminal domain [55003] (2)
20. HMA, heavy metal-associated domain [55008] (1)
21. Urease metallochaperone UreE, C-terminal domain [69737] (1)
22. ACT-like [55021] (12)
    regulatory domain linked to a wide range of metabolic enzymes
23. Bacterial exopeptidase dimerisation domain [55031] (1)
24. NAD-binding domain of HMG-CoA reductase [55035] (1)
25. Molybdenum cofactor biosynthesis protein C, MoaC [55040] (1)
26. TRADD, N-terminal domain [55044] (1)
27. Probable ACP-binding domain of malonyl-CoA ACP transacylase [55048] (1)
28. CheY-binding domain of CheA [55052] (1)
29. D-ribose-5-phosphate isomerase (RpiA), lid domain [75445] (1)
30. Killer toxin KP6 alpha-subunit [55056] (1)
31. Hypothetical protein VC0424 [89946] (1)
32. Hypothetical protein TT1725 [103007] (1)
33. Mechanosensitive channel protein MscS (YggB), C-terminal domain [82689] (1)
    the last strand of the fold is flipped away and involved in oligomerisation
34. GHMP Kinase, C-terminal domain [55060] (7)
    common fold is elaborated with additional secondary structures
35. Translational regulator protein regA [55064] (1)
    common fold is elaborated with additional secondary structures
36. Peptide methionine sulfoxide reductase [55068] (1)
    common fold is elaborated with additional secondary structures
37. Nucleotide cyclase [55073] (2)
    common fold is elaborated with additional secondary structures
38. 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK [55083] (1)
    common fold is elaborated with additional secondary structures
39. Glutamyl tRNA-reductase catalytic, N-terminal domain [69742] (1)
    common fold is elaborated with additional secondary structures
40. MTH1187/YkoF-like [89957] (2)
41. Methyl-coenzyme M reductase subunits [55088] (2)
    each of the three different subunits, alpha, beta and gamma, contains this fold decorated with additional secondary structures
42. FAD-linked oxidases, C-terminal domain [55103] (4)
    duplication: contains two subdomains of this fold
43. Formylmethanofuran:tetrahydromethanopterin formyltransferase [55112] (1)
    duplication: contains two subdomains of this fold
44. Formiminotransferase domain of formiminotransferase-cyclodeaminase. [55116] (1)
    duplication: contains two subdomains of this fold
45. Sulfite reductase, domains 1 and 3 [55124] (1)
    duplication: contains two subdomains of this fold
46. Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains [82693] (1)
    duplication: the N- and C-terminal halves of the whole proteins are structurally similar; each half contains two domains of this fold
47. YajQ-like [89963] (1)
    duplication: consists of two domains of this fold swapped with their N-terminal strands
48. eIF-2-alpha, C-terminal domain [110993] (1)
49. Sporulation related repeat [110997] (1)
    duplication: one domain contains two repeats of similar sequence and structure
50. CRISPR-associated protein [117987] (1)
    duplication: contains two subdomains of this fold
51. YbeD-like [117991] (1)
52. DOPA-like [143410] (1)
    probable biological unit is homodimer; the extra C-terminal strand, adjacent and antiparallel to strand 4, contributes to the dimerisation interface
53. CcmK-like [143414] (1)
    contains extra C-terminal helix; forms compact hexameric 'tiles' of hexagonal shape
54. Transposase IS200-like [143422] (1)
    contains extra N-terminal hairpin and C-terminal helix, both are involved in dimerization; there can be helix-swapping in the dimer
55. TTP0101/SSO1404-like [143430] (1)
    contains extra C-terminal beta-strand that integrates into the beta-sheet of the other subunit in the homodimer, a probable biological unit of this superfamily

Generated from scop database 1.73 with scopm 1.101 on Wed Nov 21 11:18:32 2007 Copyright © 1994-2007 The scop authors / scop@mrc-lmb.cam.ac.uk