Structural Classification of Proteins

Root: scop

Classes:

All alpha proteins [46456] (218)
1. Globin-like [46457] (2)
  core: 6 helices; folded leaf, partly opened
2. Long alpha-hairpin [46556] (14)
  2 helices; antiparallel hairpin, left-handed twist
3. Type I dockerin domain [63445] (1)
  tandem repeat of two calcium-binding loop-helix motifs, distinct from the EF-hand
4. LEM/SAP HeH motif [63450] (4)
  helix-extended loop-helix; parallel helices
5. KRAB domain (Kruppel-associated box, Pfam 01352) [109639] (1)
  2 helices: one short, one long; aromatic-rich iterface
6. Cytochrome c [46625] (1)
  core: 3 helices; folded leaf, opened
7. DNA/RNA-binding 3-helical bundle [46688] (13)
  core: 3-helices; bundle, closed or partly opened, right-handed twist; up-and down
8. Another 3-helical bundle [81602] (4)
  topologically similar to the DNA/RNA-binding bundles; distinct packing
9. RuvA C-terminal domain-like [46928] (9)
  3 helices; bundle, right-handed twist
10. S13-like H2TH domain [81297] (1)
  core: 3-4 helices
11. Putative DNA-binding domain [46954] (1)
  core: 3 helices; architecture is similar to that of the "winged helix" fold but topology is different
12. Spectrin repeat-like [46965] (11)
  3 helices; bundle, closed, left-handed twist; up-and-down
13. immunoglobulin/albumin-binding domain-like [46996] (7)
  3 helices; bundle, closed, left-handed twist; up-and-down; mirror topology to the spectrin-like fold
14. Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex [47004] (1)
  3 helices; bundle, closed, right-handed twist; up-and-down
15. Protozoan pheromone proteins [47013] (1)
  3 helices; bundle, closed, left-handed twist, up-and-down
16. Acyl-CoA binding protein-like [47026] (2)
  core: 3 helices; bundle, closed, left-handed twist; up-and-down
17. Kix domain of CBP (creb binding protein) [47039] (1)
  3 helices; bundle, partly opened
18. alpha-2-Macroglobulin receptor associated protein (RAP) domain 1 [47044] (1)
  3 helices, the first one is shorter than the other two; bundle, partly opened
19. VHP, Villin headpiece domain [47049] (1)
  3 short helices; irregular array
20. TAF(II)230 TBP-binding fragment [47054] (1)
  3 short helices; irregular array
21. S15/NS1 RNA-binding domain [47059] (1)
  3 helices; irregular array
22. p8-MTCP1 [47071] (1)
  3 helices; irregular array; disulfide-rich
23. Frizzled cysteine-rich domain [63500] (1)
  Core: 3 helices; irregular array; disulfide-rich
24. T4 endonuclease V [47076] (1)
  3 helices; irregular array
25. Fertilization protein [47081] (1)
  core: 3 helices; bundle, closed, right-handed twist; up-and-down
26. PGBD-like [47089] (1)
  core: 3 helices; bundle, closed, left-handed twist; parallel
27. HMG-box [47094] (1)
  3 helices; irregular array
28. Histone-fold [47112] (1)
  core: 3 helices; long middle helix is flanked at each end with shorter ones
29. Open three-helical up-and-down bundle [47143] (5)
  core: 3 helices; bundle, open
30. beta-catenin-interacting protein ICAT [81729] (1)
  core: 3 helices; irregular array
31. Four-helical up-and-down bundle [47161] (23)
  core: 4 helices; bundle, closed or partly opened, left-handed twist; up-and-down
32. PTS-regulatory domain, PRD [63519] (1)
  core: 4 helices; bundle, closed, right-handed twist; 1 crossover connection
33. Ferritin-like [47239] (2)
  core: 4 helices; bundle, closed, left-handed twist; 1 crossover connection
34. 4-helical cytokines [47265] (1)
  core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections
35. Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases [47322] (1)
  core: 4 helices; bundle; one loop crosses over one side of the bundle
36. Acyl carrier protein-like [47335] (3)
  4 helices, bundle; helix 3 is shorter than others; up-and-down
37. Bromodomain-like [47363] (6)
  4 helices; bundle; minor mirror variant of up-and-down topology
38. ROP-like [47379] (5)
  4 helices; dimer of identical alpha-hairpin subunits; bundle, closed, left-handed twist
39. Dimerization-anchoring domain of cAMP-dependent type II PK regulatory subunit [47390] (1)
  4 helices; bundle, closed, right-handed twist
40. Soluble domain of poliovirus core protein 3a [89042] (1)
  4 helices; bundle, closed, right-handed twist
41. Transcription factor IIA (TFIIA), alpha-helical domain [47395] (1)
  4 helices; bundle, closed, right-handed twist
42. Ectatomin subunits [47400] (1)
  4 helices; bundle, closed, left-handed twist
43. Dimerisation interlock [47405] (4)
  4 helices; bundle, closed, right-handed twist
44. lambda repressor-like DNA-binding domains [47412] (1)
  core: 4 helices; folded leaf, closed
45. Signal peptide-binding domain [47445] (1)
  4 helices; orthogonal array
46. A DNA-binding domain in eukaryotic transcription factors [47453] (1)
  4 helices; the long C-terminal helix protrudes from the domain and binds to DNA
47. HLH-like [47458] (2)
  4-helices; bundle, closed, left-handed twist; 2 crossover connections
48. EF Hand-like [47472] (4)
  core: 4 helices; array of 2 hairpins, opened
49. CH domain-like [47575] (2)
  core: 4 helices: bundle
50. Domain of poly(ADP-ribose) polymerase [47586] (1)
  core: 4 helices: bundle; unusual topology
51. SWIB/MDM2 domain [47591] (1)
  core: 4 helices: open bundle; capped by two small 3-stranded beta-sheets
  duplication: consists of two structural repeats
52. Pre-protein crosslinking domain of SecA [81766] (1)
  core: 4 helices: bundle; flanked by two short beta-hairpins
  duplication: consists of two structural repeats
53. Ribbon-helix-helix [47597] (1)
  core: 4 helices; array of 2 hairpins, opened
54. Glutathione S-transferase (GST), C-terminal domain [47615] (1)
  core: 4 helices; bundle, closed, left-handed twist; right-handed superhelix
55. Methionine synthase domain-like [47643] (2)
  4 helices; bundle, left-handed twist; right-handed superhelix
56. KaiA/RbsU domain [101214] (1)
  4 helices; bundle, right-handed twist; right-handed superhelix
57. STAT-like [47654] (4)
  4 long helices; bundle, left-handed twist (coiled coil); right-handed superhelix
58. N-cbl like [47667] (3)
  4 helices; bundle, left-handed twist; left-handed superhelix
59. Replisome organizer (g39p helicase loader/inhibitor protein) [89063] (1)
  4 helices; bundle, right-handed twist; left-handed superhelix
60. C-terminal domain of B transposition protein [47680] (1)
  4 helices; irregular array
61. RPB6/omega subunit-like [63561] (1)
  core: 2 helices and adjacent loops
62. HAND domain of the nucleosome remodeling ATPase ISWI [101223] (1)
  4 helices; irregular array
63. N-terminal, cytoplasmic domain of anti-sigmaE factor RseA [89068] (1)
  4 helices; irregular array
64. Anaphylotoxins (complement system) [47685] (1)
  4 helices; irregular array, disulfide-linked
65. Cytochrome c oxidase subunit h [47693] (1)
  4 helices; irregular array, disulfide-linked
66. Crustacean CHH/MIH/GIH neurohormone [81777] (1)
  4 helices; irregular array, disulfide-linked
67. C-terminal domain of DFF45/ICAD (DFF-C domain) [81782] (1)
  4 helices; folded leaf; right-handed superhelix
68. Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin [47698] (1)
  4 helices; folded leaf; right-handed superhelix
69. p53 tetramerization domain [47718] (1)
  core: 4 helices; bundle
70. Bcr-Abl oncoprotein oligomerization domain [69035] (1)
  core: 4 long helices; bundle
71. Domain of early E2A DNA-binding protein, ADDBP [47723] (1)
  4 helices; bundle, partly opened
72. IHF-like DNA-binding proteins [47728] (1)
  core: 4 helices; bundle, partly opened, capped with a beta-sheet
73. CO dehydrogenase ISP C-domain like [47740] (1)
  core: 4 helices, bundle
74. Protein HNS-dependent expression A; HdeA [47751] (1)
  4 helices; the three last helices form a bundle similar to that of the RuvA C-domain
75. PABP domain-like [63569] (2)
  4 helices; an orthogonal array
76. Chemotaxis receptor methyltransferase CheR, N-terminal domain [47756] (1)
  4 helices; an orthogonal array
77. PWI domain [101232] (1)
  4 helices; up-and-down bundle; topological similarity to the bromodomain-like and SAM domain-like folds
78. PAH2 domain [47761] (1)
  4 helices; open up-and-down bundle; binds alpha-helical peptides
79. Myosin phosphatase inhibitor 17kDa protein, CPI-17 [81789] (1)
  4 helices; open up-and-down bundle; flexible N-terminal tail
80. XPC-binding domain [101237] (1)
  4 helices; array
81. YfiT-like putative metal-dependent hydrolases [109853] (1)
  # core: 4 helices; bundle, closed, left-handed twist; an unusual topology with a higher contact order
82. NblA-like (Pfam 04485) [109858] (1)
  4 helices; dimer of identical alpha-hairpin subunits; open bundle
83. SAM domain-like [47768] (13)
  4-5 helices; bundle of two orthogonally packed alpha-hairpins; involved in the interactions with DNA and proteins
84. Retroviral matrix proteins [47835] (1)
  4-5 helices; right-handed superhelix
85. Flavivirus capsid protein C [101256] (1)
  core: 5 helices; right-handed superhelix; swapped dimer with the two long C-terminal helices
86. Hepatitis B viral capsid (hbcag) [47851] (1)
  5 helices; array; two long helices form a hairpin that dimerizes into a 4-helical bundle
87. Apolipophorin-III [47856] (1)
  5 helices; bundle, closed, left-handed twist
88. Methenyltetrahydrofolate cyclohydrolase-like [101261] (1)
  5 helices; bundle, closed, left-handed twist
89. A middle domain of Talin 1 [109879] (1)
  5 helices; bundle, closed, left-handed twist; helices 2-5 adopt the Four-helical up-and-down bundle fold (scop_cf 47161)
90. I/LWEQ domain (Pfam 01608) [109884] (1)
  5 helices; bundle, closed, left-handed twist
91. Saposin-like [47861] (2)
  5 helices; folded leaf, closed
92. Annexin [47873] (1)
  5 helices; folded leaf, closed
93. Transducin (alpha subunit), insertion domain [47894] (1)
  5 helices; folded leaf
94. Wiscott-Aldrich syndrome protein, WASP, C-terminal domain [47911] (1)
  5 helices; irregular array; left-handed superhelix
95. Left-handed superhelix [47916] (3)
  core: 4-5 helices; bundle; left-handed superhelix
96. N-terminal domain of the delta subunit of the F1F0-ATP synthase [47927] (1)
  core: 5 helices; bundle
97. ERP29 C domain-like [47932] (2)
  5 helices; bundle
98. Functional domain of the splicing factor Prp18 [47937] (1)
  core: 5 helices; bundle
99. Retrovirus capsid protein, N-terminal core domain [47942] (1)
  core: 5 helices; bundle
100. Cyclin-like [47953] (1)
  core: 5 helices; one helix is surrounded by the others
101. Arp2/3 complex 21 kDa subunit ARPC3 [69059] (1)
  5 helices; one helix is surrounded by the others
102. RNase III catalytic domain-like (Pfam 00636) [69064] (1)
  core: 5 helices; one helix is surrounded by the others
103. Ribosomal protein S7 [47972] (1)
  core: 5 helices; contains one more helix and a beta-hairpin outside the core
104. DNA polymerase III clamp loader subunits, C-terminal domain [48018] (1)
  core: 5 helices: bundle
105. PAP/OAS1 substrate-binding domain [81632] (1)
  core: 5-helical bundle; up-and-down; right-handed twist
106. Anti-sigma factor AsiA [69069] (1)
  core: 5 helices: orthogonal array
107. Antibiotic binding domain of TipA-like multidrug resistance regulators [89081] (1)
  5 helices: orthogonal array
108. Surp module (SWAP domain; Pfam 01805) [109904] (1)
  5 helices: irregular array
109. YgfY-like (DUF399, Pfam03937) [109909] (1)
  5 helices; array; forms a tight dimer in crystals
110. Hypothetical protein YhaI [109914] (1)
  core: 5 helices; orthogonal array; folding similarity to the TipA-S domain (1ny9)
111. Hypothetical protein At3g22680 [109919] (1)
  5 helices; array; probable biological unit is a homodimer
112. N-terminal domain of adenylylcyclase associated protein, CAP [101277] (1)
  6 helices: bundle; left-handed twist, up-and-down topology
113. Iron-dependent repressor protein, dimerization domain [47978] (1)
  6 helices, homodimer of 3-helical domains
114. Glutamyl tRNA-reductase dimerization domain [69074] (1)
  6 helices, homodimer of 3-helical domains
115. GRIP domain [101282] (1)
  6 helices, homodimer of 3-helical domains
116. L27 domain [101287] (1)
  6 helices, heterodimer of 3-helical domains
117. Lissencephaly-1 protein (Lis-1, PAF-AH alpha) N-terminal domain [109924] (1)
  dimer of 3-helical segments; consists of two subdomains: 4-helical bundle and coiled coil
118. DEATH domain [47985] (1)
  6 helices: closed bundle; greek-key; internal pseudo twofold symmetry
119. Fatty acid responsive transcription factor FadR, C-terminal domain [48007] (1)
  core: 6 helices: closed bundle; greek-key; internal pseudo twofold symmetry
120. NusB-like [48012] (1)
  6 helices: bundle; one central helix is surrounded by 5 others
121. YutG-like [101306] (1)
  core: 6 helices; bundle; one central helix is surrounded by 5 others
122. N-terminal domain of DnaB helicase [48023] (1)
  6 helices: array
123. Invasion protein A (SipA) , C-terminal actin binding domain [101311] (1)
  6 helices: orthogonal array
124. Guanido kinase N-terminal domain [48033] (1)
  irregular array of 6 short helices
125. Scaffolding protein gpD of bacteriophage procapsid [48044] (1)
  core: 6 helices; one central helix is surrounded by 5 others
126. Hypothetical protein Aq_328 [101316] (1)
  core: 6 helices; one central helix is surrounded by 5 others
127. Hemocyanin, N-terminal domain [48049] (1)
  6 helices; bundle; one central helix is surrounded by 5 others
128. Di-copper centre-containing domain [48055] (1)
  multihelical
129. DBL homology domain (DH-domain) [48064] (1)
  multihelical; core: 5-helical bundle
130. LigA subunit of an aromatic-ring-opening dioxygenase LigAB [48075] (1)
  multihelical; contains compact array of 6 short helices
131. RuBisCo LSMT C-terminal, substrate-binding domain [81821] (1)
  multihelical; irregular array of long and short helices
132. Porin chaperone SurA, peptide-binding domain [81826] (1)
  multihelical; irregular array of long and short helices
133. Methyl-coenzyme M reductase alpha and beta chain C-terminal domain [48080] (1)
  multihelical bundle; contains buried central helix
134. YcfC-like [101321] (1)
  multihelical; contains two buried central helices
135. Transcription factor STAT-4 N-domain [48091] (1)
  multihelical; can be divided into two subdomains
136. Regulator of G-protein signaling, RGS [48096] (1)
  multihelical; consists of two all-alpha subdomains
  contains a 4-helical bundle with left-handed twist and up-and-down topology
137. SopE-like GEF domain [81831] (1)
  multihelical; consists of two all-alpha subdomains each containing a 3-helical bundle with right-handed twist
138. Variable surface antigen VlsE [74747] (1)
  multihelical; consists of two all-alpha subdomains; contains a 4-helical bundle with left-handed twist and up-and-down topology
139. YgfB-like [101326] (1)
  multihelical; consists of two tightly associated 3-helical bundles with different twists
140. Hypothetical protein MTH393 [101331] (1)
  multihelical; consists of two all-alpha subdomains; dimer
141. Carbamoyl phosphate synthetase, large subunit connection domain [48107] (1)
  multihelical; consists of two all-alpha subdomains
  possible duplication: subdomains have similar topologies
142. Heme-dependent peroxidases [48112] (1)
  multihelical; consists of two all-alpha domains
143. Ribosomal protein L19 (L19e) [48139] (1)
  multihelical; consists of two different 3-helical domains connected by a long, partly helical linker
144. GatB/YqeY domain [89094] (1)
  multihelical; consists of two different alpha-helical bundles (4-helical and 3-helical)
145. HD-domain/PDEase-like [109603] (1)
  multihelical; consists of two different alpha-helical bundles
146. Superantigen MAM [101343] (1)
  multihelical; consists of two different alpha-helical bundles
147. Influenza virus matrix protein M1 [48144] (1)
  multihelical; consists of two different all-alpha subdomains, 4 helices each
148. DNA-glycosylase [48149] (1)
  multihelical; consists of two all-alpha domains
149. An anticodon-binding domain of class I aminoacyl-tRNA synthetases [48162] (1)
  multihelical; consists of two all-alpha domains
150. Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) [101352] (1)
  multihelical; consists of two all-alpha subdomains
151. R1 subunit of ribonucleotide reductase, N-terminal domain [48167] (1)
  multihelical consists of two all-alpha subdomains
  subdomain 1 (residues 10-100) is a 4-helical bundle
152. BEACH domain [81836] (1)
  multihelical, complex architecture
153. Cryptochrome/photolyase FAD-binding domain [48172] (1)
  multihelical; consists of two all-alpha subdomains
154. 6-phosphogluconate dehydrogenase C-terminal domain-like [48178] (1)
  multihelical; common core is formed around two long antiparallel helices related by (pseudo) twofold symmetry
155. Uteroglobin-like [48200] (1)
  multihelical
156. alpha/alpha toroid [48207] (5)
  multihelical; up to seven alpha-hairpins are arranged in closed circular array; there may be sequence similarities between different superfamilies
157. Citrate synthase [48255] (1)
  multihelical; consists of two all-alpha domains
158. Cytochrome P450 [48263] (1)
  multihelical
159. Flagellar transcriptional activator FlhD [63591] (1)
  multihelical; forms intertwined dimer of identical 5-helical subunits
160. Ribosomal protein L7/12, oligomerisation (N-terminal) domain [48299] (1)
  multihelical; intertwined tetramer
161. Class II MHC-associated invariant chain ectoplasmic trimerization domain [48304] (1)
  multihelical; intertwined trimer of identical 3-helical subunits
162. Aldehyde ferredoxin oxidoreductase, C-terminal domains [48309] (1)
  multihelical; consists of two all-alpha domains
163. Acid phosphatase/Vanadium-dependent haloperoxidase [48316] (1)
  multihelical; core: 5-helical bundle; binds cofactor at the beginning of third helix
164. BRCA2 helical domain [81871] (1)
  multihelical; contains a 3-helical bundle surrounded by several shorter helices
165. BRCA2 tower domain [81877] (1)
  multihelical; contains a 3-helical Hin recombinase-like subdomain and two long dimerisation helices
166. H-NS histone-like proteins [81274] (1)
  multihelical oligomeric protein; structure of whole subunit is not known yet but are probably composed of three different domains
167. Sigma2 domain of RNA polymerase sigma factors [88945] (1)
  multihelical; consists of a conserved 4-helical core and a variable insert subdomain
168. DNA repair protein MutS, domain III [48333] (1)
  multihelical; consists of 2 all-alpha subdomains
169. Helical scaffold and wing domains of SecA [81885] (1)
  multihelical; consists of 2 all-alpha subdomains
170. Type II deoxyuridine triphosphatase [101385] (1)
  multihelical; consists of 2 all-alpha subdomains, "rigid" one and "mobile" one
171. Hsp90 co-chaperone CDC37 [101390] (1)
  multihelical; consists of 2 all-alpha subdomains connected by a long helix
172. Nop domain [89123] (1)
  multihelical; array of longer and shorter helices; contains an alpha-hairpin dimerisation subdomain
173. Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain [48339] (1)
  multihelical; bundle of longer and shorter helices
174. A virus capsid protein alpha-helical domain [48344] (1)
  multihelical; three-helical bundle in the core is surrounded by non-conserved helices
175. P40 nucleoprotein [101398] (1)
  multihelical; consists of two subdomains
176. GTPase activation domain, GAP [48349] (1)
  multihelical
177. Ras GEF [48365] (1)
  multihelical
178. Telomeric repeat binding factor (TRF) dimerisation domain [63599] (1)
  multihelical; can be divided into an alpha-alpha superhelix domain and a long alpha-hairpin dimerization domain
179. Poly A polymerase C-terminal region-like [81890] (1)
  multihelical; can be divided into three subdomains (neck, body and tail)
180. alpha-alpha superhelix [48370] (20)
  multihelical; 2 (curved) layers: alpha/alpha; right-handed superhelix
181. Lipoxigenase [48483] (1)
  multihelical
  large nearly all-alpha domain
182. gene 59 helicase assembly protein [48492] (1)
  multihelical; consists of two all-alpha subdomains
183. Tetracyclin repressor-like, C-terminal domain [48497] (1)
  multihelical; interlocked (homo)dimer
184. Skp1 dimerisation domain-like [81384] (1)
  multihelical; interlocked heterodimer with F-box proteins
185. F-box domain [81385] (1)
  multihelical; interlocked heterodimer with the Skp1 dimerisation domain
186. Nuclear receptor ligand-binding domain [48507] (1)
  multihelical; 3 layers or orthogonally packed helices
187. Phospholipase C/P1 nuclease [48536] (1)
  multihelical
188. VPS9 domain (Pfam 02204) [109992] (1)
  multihelical; consist of two subdomains
189. TF C-terminus (Pfam 05698) [109997] (1)
  multihelical; open array
190. Glycolipid transfer protein, GLTP [110003] (1)
  multihelical; 2 layers or orthogonally packed helices
191. Hypothetical protein MG354 [110008] (1)
  multihelical bundle; contains buried central helix
192. Her-1 [110013] (1)
  multihelical; consists of two topologically similar alpha-helical bundles
193. ERO1-like (Pfam 04137) [110018] (1)
  multihelical; consists of 2 four-helical bundles
194. Serum albumin-like [48551] (1)
  multihelical; one domain consists of two similar disulfide-linked subdomains
195. L-aspartase-like [48556] (1)
  multihelical, consists of three all-alpha domains
196. Formin homology 2 domain (FH2 domain) [101446] (1)
  multihelical, consists of three all-alpha domains
197. Terpenoid synthases [48575] (1)
  multihelical; core: 8 helices (C-J) are arranged in 2 parallel layers
198. GroEL equatorial domain-like [48591] (1)
  multihelical; 8 helices arranged in 2 parallel layers
199. TorD-like (Pfam 06192) [89154] (1)
  multihelical; bundle
200. Chorismate mutase II [48599] (1)
  multihelical; core: 6 helices, bundle
201. Peridinin-chlorophyll protein [48607] (1)
  multihelical: forms a boat-shaped protein shell around cofactors
202. Heme oxygenase-like [48612] (1)
  multihelical; bundle
203. AhpD-like [69117] (1)
  multihelical; contains 4-helical bundle and 2-helical arm
204. Double Clp-N motif [81922] (1)
  multihelical; array
205. Orange carotenoid protein, N-terminal domain [81929] (1)
  multihelical; array
206. Citrobacter dihydroxyacetone kinase extra ATP-binding domain [101472] (1)
  multihelical; bundle
207. ADP-ribosylglycohydrolase [101477] (1)
  multihelical; bundle
208. Gametocyte protein Pfg27 [89161] (1)
  multihelical; bundle
209. N-terminal domain of bifunctional PutA protein [81934] (1)
  multihelical; array
210. Phospholipase A2, PLA2 [48618] (1)
  common core: 2 helices, disulfide-linked, and a calcium-binding loop
211. Fungal elicitin [48646] (1)
  5 helices: irregular disulfide-linked array; also contains a small beta-hairpin
212. Tetraspanin [48651] (1)
  5 helices: irregular disulfide-linked array; form homodimer
213. GDNF receptor-like (Pfam 02351) [110034] (1)
  5 helices: irregular disulfide-linked array; topological similarity to the Fungal elicitin fold (scop_cf 48646)
214. Repressor of bacterial conjugation FinO [48656] (1)
  6 helices: irregular non-globular array; also contains two small b-hairpins
215. Nuclear receptor coactivator interlocking domain [69124] (1)
  3 helices, non-globular array; forms interlocked heterodimers with its targets
216. Eukaryotic initiation factor 4f subunit eIF4g, eIF4e-binding domain [101488] (1)
  5 helices, non-globular array; wraps around the N-terminal tail of its target
217. Non-globular all-alpha subunits of globular proteins [48661] (10)
  not a true fold
218. Multiheme cytochromes [48694] (1)
  variable number of helices and little beta structure; not a true fold
All beta proteins [48724] (144)
1. Immunoglobulin-like beta-sandwich [48725] (23)
  sandwich; 7 strands in 2 sheets; greek-key
  some members of the fold have additional strands
2. Common fold of diphtheria toxin/transcription factors/cytochrome f [49379] (10)
  sandwich; 9 strands in 2 sheet; greek-key; subclass of immunoglobin-like fold
3. Prealbumin-like [49451] (6)
  sandwich; 7 strands in 2 sheets, greek-key
  variations: some members have additional 1-2 strands to common fold
4. HSP40/DnaJ peptide-binding domain [49492] (1)
  sandwich; 6 strands in 2 sheets
5. Penicillin-binding protein associated domain [69188] (1)
  sandwich; 6 strands in 2 sheets
6. alpha-Amylase inhibitor tendamistat [49497] (1)
  sandwich; 6 strands in 2 sheets
7. C-terminal domain of mollusc hemocyanin [81278] (1)
  six-stranded beta-sandwich, jelly-roll/greek-key topology
8. Cupredoxin-like [49502] (2)
  sandwich; 7 strands in 2 sheets, greek-key
  variations: some members have additional 1-2 strands
9. Ctag/Cox11 (Pfam 04442) [110110] (1)
  sandwich; 7 strands in 2 sheets, greek-key; permutation of the immunoglobulin-like fold
10. C2 domain-like [49561] (4)
  sandwich; 8 strands in 2 sheets; greek-key
11. TRAF domain-like [49598] (1)
  sandwich; 8 strands in 2 sheets; greek-key
12. Neurophysin II [49605] (1)
  sandwich; 8 strands in 2 sheets; meander
13. N-utilization substance G protein NusG, insert domain [82003] (1)
  sandwich; 8 strands in 2 sheets; meander
14. Nucleoplasmin-like/VP (viral coat and capsid proteins) [88632] (7)
  sandwich; 8 strands in 2 sheets; jelly-roll; some members can have additional 1-2 strands
  characteristic interaction between the domains of this fold allows the formation of five-fold and pseudo six-fold assemblies
15. gamma-Crystallin-like [49694] (1)
  sandwich; 8 strands in 2 sheets; greek-key
  duplication: has internal pseudo twofold symmetry
16. Lipase/lipooxygenase domain (PLAT/LH2 domain) [49722] (1)
  sandwich; 8 strands in 2 sheets; complex topology
  duplication: has weak internal pseudo twofold symmetry
17. Calpain large subunit, middle domain (domain III) [49757] (1)
  sandwich; 8 strands in 2 sheets; jelly-roll
18. Supernatant protein factor (SPF), C-terminal domain [101575] (1)
  sandwich; 8 strands in 2 sheets; jelly-roll; similarity to the Nucleoplasmin-like/VP fold
19. Hypothetical protein TM1070 [89231] (1)
  sandwich; 8 strands in 2 sheets; jelly-roll
20. Olfactory marker protein [63696] (1)
  sandwich; 8 strands in 2 sheets; jelly-roll
21. HSP20-like chaperones [49763] (1)
  sandwich; 8 strands in 2 sheets; greek-key
22. Heat shock protein 70kD (HSP70), peptide-binding domain [100919] (1)
  beta-sandwich: 8 strands in 2 sheets
23. Ecotin, trypsin inhibitor [49771] (1)
  sandwich; 8 strands in 2 sheets; complex topology with the crossing loops
24. PEBP-like [49776] (1)
  sandwich; 8 strands in 2 sheets; greek-key: partial topological similarity to immunoglobulin-like folds
25. Ganglioside M2 (gm2) activator [63706] (1)
  sandwich; 8 strands in 2 sheets; greek-key: partial topological similarity to immunoglobulin-like folds
26. Nicotinic receptor ligand binding domain-like [63711] (1)
  sandwich; 8 strands in 2 sheets; greek-key: partial topological similarity to immunoglobulin-like folds
27. Galactose-binding domain-like [49784] (1)
  sandwich; 9 strands in 2 sheets; jelly-roll
28. Viral protein domain [49817] (1)
  sandwich; 9 strands in 2 sheets; jelly-roll; form trimers
29. Calcium-mediated lectin [82025] (1)
  sandwich; 9 strands in 2 sheets; greek-key
30. Dextranase, N-terminal domain [101595] (1)
  sandwich; 9 strands in 2 sheets; greek-key
31. Unnamed hypothetical protein [101600] (1)
  sandwich; 9 strands in 2 sheets; greek-key/jelly-roll
32. Superantigen (mitogen) Ypm [101605] (1)
  sandwich; 9 strands in 2 sheets; jelly-roll
33. ENV polyprotein, receptor-binding domain [49829] (1)
  sandwich; 9 strands in 2 sheets; greek-key; contains a few helices in loop regions
34. BTV NS2-like ssRNA-binding domain (N-terminal half of Pfam 04514) [110131] (1)
  sandwich; 9 strands in 2 sheets; unusual topology with 2 crossover loops
35. Virus attachment protein globular domain [49834] (1)
  sandwich, 10 strands in 2 sheets; greek-key
36. TNF-like [49841] (1)
  sandwich, 10 strands in 2 sheets; jelly-roll
37. CUB-like [49853] (2)
  sandwich, 10 strands in 2 sheets; jelly-roll
38. Hyaluronate lyase-like, C-terminal domain [49862] (1)
  sandwich, 10 strands in 2 sheets; "folded meander"
39. Anemone pore-forming cytolysin [63723] (1)
  sandwich, 10 strands in 2 sheets;
40. Osmotin, thaumatin-like protein [49869] (1)
  sandwich; 11 strands in 2 sheets
41. SMAD/FHA domain [49878] (1)
  sandwich; 11 strands in 2 sheets; greek-key
42. Soluble secreted chemokine inhibitor, VCCI [49888] (1)
  sandwich; 11 strands in 2 sheets; greek-key
43. Baculovirus p35 protein [49893] (1)
  sandwich; 14 strands in 2 sheets; greek-key
44. Concanavalin A-like lectins/glucanases [49898] (1)
  sandwich; 12-14 strands in 2 sheets; complex topology
45. Supersandwich [49993] (3)
  sandwich; 18 strands in 2 sheets
46. Leukotriene A4 hydrolase N-terminal domain [63736] (1)
  duplication: two beta-sandwiches of similar topologies are fused together in a single three beta-sheet domain
47. EV matrix protein [50011] (1)
  consists of two beta-sandwich domains of similar topologies
48. Viral chemokine binding protein m3 [82045] (1)
  consists of two different beta-sandwich domains of partial topological similarity to immunoglobulin-like folds
49. gp9 [50016] (1)
  consists of two different beta-sandwich domains unrelated to other beta-sandwich folds
50. ISP domain [50021] (1)
  consists of two all-beta subdomains: conserved small domain has a rubredoxin-like fold; larger domain consists of 6 beta-stands packed in either sandwich of two 3-stranded sheets or closed barrel (n=6; S=8)
51. Obg-fold [82050] (1)
  this fold is formed by three glycine-rich regions inserted into a small 8-stranded beta-sandwich
  these regions form six left-handed collagen-like helices packed and H-bonded together
52. SH3-like barrel [50036] (15)
  barrel, partly opened; n*=4, S*=8; meander
  the last strand is interrupted by a turn of 3-10 helix
53. GroES-like [50128] (2)
  contains barrel, partly opened; n*=4, S*=8; meander
54. PDZ domain-like [50155] (1)
  contains barrel, partly opened; n*=4, S*=8; meander; capped by alpha-helix
55. N-terminal domains of the minor coat protein g3p [50175] (1)
  core: barrel, in some members open; n*=4, S*=8; meander
56. Sm-like fold [50181] (2)
  core: barrel, open; n*=4, S*=8; meander; SH3-like topology
57. Stringent starvation protein B, SspB [101737] (1)
  core: barrel, open; n*=4, S*=8; meander; SH3-like topology; some similarity to the Sm-like fold
58. RNase P subunit p29-like [101743] (1)
  core: barrel, open; n*=4, S*=8; meander; SH3-like topology; some similarity to the Sm-like fold
59. Hydrophobin II, HfbII [101750] (1)
  core: barrel, closed; n=4, S=8; complex topology; helix-containing crossover connection
60. Ribosomal protein L14 [50192] (1)
  barrel, closed; n=5, S=8, meander
61. OB-fold [50198] (10)
  barrel, closed or partly opened n=5, S=10 or S=8; greek-key
62. PRC-barrel domain [50345] (1)
  core: barrel, partly opened; n*=5, S*=8; meander
63. beta-Trefoil [50352] (8)
  barrel, closed; n=6, S=12; and a hairpin triplet; meander
  duplication: has internal pseudo threefold symmetry
64. Reductase/isomerase/elongation factor common domain [50412] (4)
  barrel, closed; n=6, S=10; greek-key
65. Elongation factor/aminomethyltransferase common domain [50464] (2)
  barrel, closed; n=6, S=10; greek-key
66. FMN-binding split barrel [50474] (1)
  barrel; n=6, S=10; greek-key
67. Phage tail proteins [69278] (1)
  core: barrel; n=6, S=10; greek-key; topologically similar to the FMN-binding split barrel
68. Surface presentation of antigens (SPOA) [101800] (1)
  segment-swapped dimer forming two identical conjoint barrels (n=6, S=10) topologically similar to the FMN-binding split barrel
69. FMT C-terminal domain-like [50485] (1)
  barrel, open; n*=6, S*=10; greek-key
70. Trypsin-like serine proteases [50493] (1)
  barrel, closed; n=6, S=8; greek-key
  duplication: consists of two domains of the same fold
71. Replicase NSP9 [101815] (1)
  barrel; n=6, S=8, greek-key; similar to one trypsin-like protease barrel
72. mu transposase, C-terminal domain [50609] (1)
  barrel; n=6, S=8, greek-key
73. Domain of alpha and beta subunits of F1 ATP synthase-like [50614] (3)
  barrel, closed; n=6, S=8; greek-key
74. Small protein B (SmpB) [74981] (1)
  barrel, closed; n=6, S=8, greek-key, partial similarity to the OB-fold
75. Acid proteases [50629] (1)
  barrel, closed; n=6, S=10, complex topology
76. ValRS/IleRS/LeuRS editing domain [50676] (1)
  core: barrel, closed; n=6, S=8; topology is similar to that of the acid proteases barrel
77. Urease metallochaperone UreE, N-terminal domain [69286] (1)
  barrel, closed; n=6, S=8; a crossover loop topology
78. Double psi beta-barrel [50684] (2)
  barrel, closed; n=6, S=10; complex topology with crossover (psi) loops
79. Ribosomal protein L25-like [50714] (1)
  barrel, closed; n=6, S=10; complex topology
80. Core binding factor beta, CBF [50722] (1)
  barrel, closed; n=6, S=10; meander; capped at both ends by alpha-helices
81. PH domain-like [50728] (1)
  barrel, partly opened; n*=6, S*=12; meander; capped by an alpha-helix
82. Transcription factor IIA (TFIIA), beta-barrel domain [50783] (1)
  barrel, closed; n=6, S=12; mixed beta-sheet
83. Herpes virus serine proteinase, assemblin [50788] (1)
  core: barrel, closed; n=7, S=8; complex topology
84. PK beta-barrel domain-like [50799] (1)
  barrel, closed; n=7, S=10; complex topology
85. XRCC4, N-terminal domain [50808] (1)
  barrel, closed; n=7, S=10; order: 1234765; strands 1 and 5 are parallel to each other
86. HesB-like domain [89359] (1)
  barrel, closed; n=7, S=10; complex topology
87. Bacterial fluorinating enzyme, C-terminal domain [101851] (1)
  barrel, closed; n=7, S=10; greek-key topology; one overside connection
88. SPOC domain-like [100938] (1)
  barrel, closed; n=7, S=10; complex topology
89. FAS1 domain [82152] (1)
  core: barrel, closed; n=7, S=12; meander
90. Lipocalins [50813] (1)
  barrel, closed or opened; n=8, S=12; meander
91. Streptavidin-like [50875] (6)
  barrel, closed; n=8, S=10; meander
92. Cyclophilin-like [50890] (1)
  barrel, closed; n=8, S=10; complex topology
93. Oncogene products [50903] (1)
  barrel, closed; n=8, S=10; one overside connection
94. Sortase [63816] (1)
  barrel, closed; n=8, S=10; mixed sheet; two overside connections
95. Mannose 6-phosphate receptor domain [50910] (1)
  barrel, partly open; n*=8, S*=10; one psi loop
96. triple barrel [50915] (1)
  dimer of two non-identical subunits; forms two similar barrels, n=8, S=10 each, that are fused together with the formation of third barrel, n=6, S=8
97. 4-bladed beta-propeller [50922] (1)
  consists of four 4-stranded beta-sheet motifs; meander
98. 5-bladed beta-propeller [50933] (3)
  consists of five 4-stranded beta-sheet motifs; meander
99. 6-bladed beta-propeller [50938] (10)
  consists of six 4-stranded beta-sheet motifs; meander
100. 7-bladed beta-propeller [50964] (13)
  consists of seven 4-stranded beta-sheet motifs; meander
101. 8-bladed beta-propeller [50997] (3)
  consists of eight 4-stranded beta-sheet motifs; meander
  also found in some members of the WD40-repeat superfamily
102. Glycosyl hydrolase domain [51010] (1)
  folded sheet; greek-key
103. WW domain-like [51044] (3)
  core: 3-stranded meander beta-sheet
104. Head domain of nucleotide exchange factor GrpE [51063] (1)
  small mixed beta-sheet, 4 "generalized" strands
105. Coronavirus RNA-binding domain (N-terminal part of Pfam 00937) [110303] (1)
  coiled antiparallel beta-sheet of 5 strands, order 51324; complex topology, crossing loops
106. Ribonuclease domain of colicin E3 [63839] (1)
  twisted meander beta-sheet of 6 strands
107. Type II restriction endonuclease effector domain [101935] (1)
  core: twisted 7-stranded beta-sheet (half-barrel) of complex topology
108. NAC domain [101940] (1)
  core: twisted 7-stranded beta-sheet (half-barrel)
109. Carbonic anhydrase [51068] (1)
  single sheet; 10 strands
110. Lipoprotein localization factors LolAB [89391] (1)
  11 stranded sheet partly folded in a corner-like structure filled with a few short helices
111. Bacteriochlorophyll A protein [51080] (1)
  single sheet; 16 strands; meander
112. open-sided beta-meander [51086] (2)
  single sheet formed by beta-hairpin repeats; exposed on both sides in the middle
113. beta-Prism I [51091] (3)
  consists of 3 4-stranded sheets; strands are parallel to the 3-fold axis
  duplication: has internal pseudo threefold symmetry
114. beta-Prism II [51109] (1)
  consists of 3 4-stranded sheets; strands are perpendicular to the 3-fold axis
  duplication: consists of two domains of this fold
115. Single-stranded right-handed beta-helix [51125] (7)
  superhelix turns are made of parallel beta-strands and (short) turns
116. Single-stranded left-handed beta-helix [51160] (3)
  superhelix turns are made of parallel beta-strands and (short) turns
117. Double-stranded beta-helix [51181] (7)
  one turn of helix is made by two pairs of antiparallel strands linked with short turns
  has appearance of a sandwich of distinct architecture and jelly-roll topology
118. Triple-stranded beta-helix [69348] (1)
  (homo)trimer; each chain donates 3 beta-strands per turn of the helix
119. Triple beta-spiral [51224] (1)
  trimer formed by the interlocking beta-hairpin repeat units
120. Trimeric adhesin [101998] (1)
  trimer; contains two different beta-prism-like domains connected by an linker subdomain of less regular structure
121. beta-hairpin stack [69359] (1)
  Trp-rich beta-hairpin repeat units form helical structures of 3 units per turn
122. Barrel-sandwich hybrid [51229] (4)
  sandwich of half-barrel shaped beta-sheets
123. beta-clip [51268] (7)
  double-stranded ribbon sharply bent in two places; the ribbon ends form incomplete barrel; jelly-roll
124. C-terminal autoproteolytic domain of nucleoporin nup98 [82214] (1)
  multisheet protein with a mixture of beta-sandwich and beta-prism features
125. Adsorption protein p2 [89427] (1)
  multisheet protein containing partial beta-propeller and beta-sandwich regions
126. Baseplate structural protein gp8 [89432] (1)
  multisheet protein with a mixture of beta-sandwich and beta-barrel features
127. Hedgehog/intein (Hint) domain [51293] (1)
  complex fold made of five beta-hairpin units and a b-ribbon arc
128. LexA/Signal peptidase [51305] (1)
  complex fold made of several coiled beta-sheets; contains an SH3-like barrel
129. Cloacin translocation domain [69368] (1)
  complex fold made of several coiled beta-sheets
130. Mss4-like [51315] (1)
  complex fold made of several coiled beta-sheets
131. Cyanovirin-N [51321] (1)
  complex fold
132. Tp47 lipoprotein, N-terminal domain [82219] (1)
  complex fold; consists of two intertwined subdomains
133. Methuselah ectodomain [63876] (1)
  complex fold
134. Head-binding domain of phage P22 tailspike protein [51326] (1)
  complex fold made of bifurcated and partly folded beta-sheet
135. E2 regulatory, transactivation domain [51331] (1)
  complex fold made of bifurcated and coiled beta-sheets
136. MoeA N-terminal region -like [63881] (1)
  complex fold made of bifurcated and coiled b-sheets
137. Composite domain of metallo-dependent hydrolases [51337] (1)
  pseudobarrel; mixed sheet of 7 strand folded upon itself and "buckled" by two beta-turns
138. Epsilon subunit of F1F0-ATP synthase N-terminal domain [51343] (1)
  pseudobarrel: sandwich of two sheets packed at a positive interstrand angle and interconnected with many short turns
139. N-terminal domain of MutM-like DNA repair proteins [81625] (1)
  pseudobarrel; capped on both ends by alpha-helices
140. Hypothetical protein YojF [89441] (1)
  pseudobarrel; capped at one end by an alpha-helix
141. AbrB/MazE/MraZ-like [89446] (1)
  pseudobarrel; capped on both ends by alpha-helices
142. PUA domain-like [88696] (1)
  pseudobarrel; mixed folded sheet of 5 strands; order 13452; strand 1 and 3 are parallel to each other
143. AXH domain [102030] (1)
  pseudobarrel; some similarity to OB-fold
144. P-domain of calnexin/calreticulin [63886] (1)
  non-globular proline-rich hairpin
Alpha and beta proteins (a/b) [51349] (136)
Mainly parallel beta sheets (beta-alpha-beta units)
1. TIM beta/alpha-barrel [51350] (31)
  contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
  the first seven superfamilies have similar phosphate-binding sites
2. NAD(P)-binding Rossmann-fold domains [51734] (1)
  core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
  The nucleotide-binding modes of this and the next two folds/superfamilies are similar
3. FAD/NAD(P)-binding domain [51904] (1)
  core: 3 layers, b/b/a; central parallel beta-sheet of 5 strands, order 32145; top antiparallel beta-sheet of 3 strands, meander
4. Nucleotide-binding domain [51970] (1)
  3 layers: a/b/a; parallel beta-sheet of 5 strands, order 32145; Rossmann-like
5. MurCD N-terminal domain [51983] (1)
  3 layers: a/b/a; parallel beta-sheet of 5 strands, order 32145; incomplete Rossmann-like fold; binds UDP group
6. 7-stranded beta/alpha barrel [51988] (3)
  variant of beta/alpha barrel; parallel beta-sheet barrel, closed, n=7, S=8; strand order 1234567; some members may have fewer strands
7. PFL-like glycyl radical enzymes [51997] (1)
  contains: barrel, closed; n=10, S=10; accommodates a hairpin loop inside the barrel
8. The "swivelling" beta/beta/alpha domain [52008] (8)
  3 layers: b/b/a; the central sheet is parallel, and the other one is antiparallel; there are some variations in topology
  this domain is thought to be mobile in most multi-domain proteins known to contain it
9. Barstar-like [52037] (2)
  2 layers, a/b; parallel beta-sheet of 3 strands, order 123
10. MurF and HprK N-domain-like [63417] (2)
  core: 3 layers, a/b/a; parallel beta-sheet of 4 strands, order 1234; structural similarity of the MurF and HprK extends beyond the core.
11. Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) [52046] (3)
  2 curved layers, a/b; parallel beta-sheet; order 1234...N; there are sequence similarities between different superfamilies
12. Ribosomal proteins L15p and L18e [52079] (1)
  core: three turns of irregular (beta-beta-alpha)n superhelix
13. SpoIIaa-like [52086] (2)
  core: 4 turns of a (beta-alpha)n superhelix
14. ClpP/crotonase [52095] (1)
  core: 4 turns of (beta-beta-alpha)n superhelix
15. BRCT domain [52112] (1)
  3 layers, a/b/a; core: parallel beta-sheet of 4 strands, order 2134
16. Lumazine synthase [52120] (1)
  3 layers, a/b/a; core: parallel beta-sheet of 4 strands, order 2134
17. DNA glycosylase [52140] (1)
  3 layers, a/b/a; core: parallel beta-sheet of 4 strands, order 2134
18. Creatininase [102214] (1)
  3 layers, a/b/a; core: parallel beta-sheet of 4 strands, order 2134
19. DNA polymerase III psi subunit [102219] (1)
  3 layers, a/b/a; parallel beta-sheet of 4 strands, order 2134
20. Initiation factor IF2/eIF5b, domain 3 [52155] (1)
  3 layers, a/b/a; core: parallel beta-sheet of 4 strands, order 2134
21. Aminoacid dehydrogenase-like, N-terminal domain [53222] (1)
  core: 3 layers: a/b/a; parallel beta-sheet of 4 strands; 2134
22. Toprim domain (Pfam 01751) [110454] (1)
  3 layers, a/b/a; parallel beta-sheet of 4 strands, order 2134
23. Hypothetical protein PA1492 [110459] (1)
  3 layers, a/b/a; parallel beta-sheet of 4 strands, order 2134
24. Ribosomal protein L13 [52160] (1)
  3 layers, a/b/a; core: parallel beta-sheet of 4 strands, order 3214
25. Ribosomal protein L4 [52165] (1)
  3 layers, a/b/a; core: parallel beta-sheet of 4 strands, order 1423
26. Flavodoxin-like [52171] (15)
  3 layers, a/b/a; parallel beta-sheet of 5 strand, order 21345
27. Methylglyoxal synthase-like [52334] (1)
  3 layers, a/b/a; parallel beta-sheet of 5 strands, order 32145
28. Ferredoxin reductase-like, C-terminal NADP-linked domain [52342] (1)
  3 layers, a/b/a; parallel beta-sheet of 5 strands, order 32145
29. Adenine nucleotide alpha hydrolase-like [52373] (3)
  core: 3 layers, a/b/a ; parallel beta-sheet of 5 strands, order 32145
30. Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain [52417] (1)
  3 layers: a/b/a; parallel beta-sheet of 5 strands, order 32145; Rossmann-like
31. Cryptochrome/photolyase, N-terminal domain [52424] (1)
  3 layers: a/b/a; parallel beta-sheet of 5 strands, order 32145; Rossmann-like
32. YchN-like [75168] (1)
  3 layers: a/b/a, core: parallel beta-sheet of 5 strands, order 43215
33. PIN domain-like [88722] (1)
  3 layers, a/b/a; core: parallel beta-sheet of 5 strands, order 32145
34. Ribose/Galactose isomerase RpiB/AlsB [89622] (1)
  3 layers: a/b/a, core: parallel beta-sheet of 5 strands, order 21354; topological similarity to a part of the arginase/deacetylase fold
35. alpha/beta knot [75216] (1)
  core: 3 layers: a/b/a, parallel beta-sheet of 5 strands, order 21435; contains a deep trefoil knot
36. PreATP-grasp domain [52439] (1)
  3 layers: a/b/a; parallel or mixed beta-sheet of 4 to 6 strands
  possible rudiment form of Rossmann-fold domain
37. DHS-like NAD/FAD-binding domain [52466] (1)
  3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456; Rossmann-like
38. Tubulin nucleotide-binding domain-like [52489] (1)
  3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456
39. Isochorismatase-like hydrolases [52498] (1)
  3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456
40. Dipeptide transport protein [63991] (1)
  3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456; also contains a C-terminal alpha+beta subdomain
41. Homo-oligomeric flavin-containing Cys decarboxylases, HFCD [52506] (1)
  3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456
42. HAD-like [56783] (1)
  3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456
43. NagB/RpiA/CoA transferase-like [100949] (1)
  core: 3 layers: a/b/a; parallel or mixed beta-sheet of 6 strands, order 321456
44. Hypothetical protein MTH777 (MT0777) [75180] (1)
  3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456
45. Thiamin pyrophosphokinase, catalytic domain [63998] (1)
  3 layers: a/b/a; parallel beta-sheet of 6 strands, order 432156
46. Undecaprenyl diphosphate synthase [64004] (1)
  3 layers: a/b/a; parallel beta-sheet of 6 strands, order 342156
47. F420-dependent methylenetetrahydromethanopterin dehydrogenase (MTD) [102323] (1)
  3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213456
48. Thiamin diphosphate-binding fold (THDP-binding) [52517] (1)
  3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465
49. P-loop containing nucleoside triphosphate hydrolases [52539] (1)
  3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes
50. PTS IIb component [52727] (1)
  3 layers: a/b/a, parallel beta-sheet of 6 strands, order 324156
51. DNA polymerase III chi subunit [102399] (1)
  3 layers, a/b/a; parallel beta-sheet of 7 strands, order 7165243
52. Nicotinate mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase (CobT) [52732] (1)
  3 layers: a/b/a, parallel beta-sheet of 7 strands, order 3214567
53. Putative lysine decarboxylase [102404] (1)
  3 layers: a/b/a, parallel beta-sheet of 7 strands, order 4321567
54. Methylesterase CheB, C-terminal domain [52737] (1)
  3 layers: a/b/a, parallel beta-sheet of 7 strands, order 3421567
55. Subtilisin-like [52742] (1)
  3 layers: a/b/a, parallel beta-sheet of 7 strands, order 2314567; left-handed crossover connection between strands 2 & 3
56. Indigoidine synthase A-like (Pfam 04227) [110580] (1)
  core: 3 layers, a/b/a; parallel beta-sheet of 7 strands, order 2134756
57. Arginase/deacetylase [52767] (1)
  3 layers: a/b/a, parallel beta-sheet of 8 strands, order 21387456
58. Alpha-2,3/8-sialyltransferase CstII [102413] (1)
  3 layers: a/b/a; parallel beta-sheet of 8 strands, order 54321678
59. Cell-division inhibitor MinC, N-terminal domain [64042] (1)
  beta(2)-(alpha-beta)2-beta; 2 layers, a/b; mixed beta-sheet of 5 strands, order 12345; strands 1 & 5 are antiparallel to the rest
60. DTD-like (Pfam 02580) [69499] (1)
  beta(2)-(alpha-beta)2-beta(3); 3 layers, a/b/b; some topological similarity to the N-terminal domain of MinC
61. CoA-dependent acyltransferases [52776] (1)
  core: 2 layers, a/b; mixed beta-sheet of 6 strands, order 324561; strands 3 & 6 are antiparallel to the rest
62. Phosphotyrosine protein phosphatases I-like [52787] (2)
  3 layers: a/b/a; parallel beta-sheet of 4 strands, order 2134
63. (Phosphotyrosine protein) phosphatases II [52798] (1)
  core: 3 layers, a/b/a; parallel beta-sheet of 4 strands, order 1423
64. Rhodanese/Cell cycle control phosphatase [52820] (1)
  3 layers: a/b/a; parallel beta-sheet of 5 strands, order 32451
65. Thioredoxin fold [52832] (2)
  core: 3 layers, a/b/a; mixed beta-sheet of 4 strands, order 4312; strand 3 is antiparallel to the rest
66. Peptidyl-tRNA hydrolase II [102461] (1)
  3 layers: a/b/a; mixed beta-sheet of 4 strands, order 2143, strand 4 is antiparallel to the rest
67. TK C-terminal domain-like [52921] (1)
  3 layers: a/b/a; mixed beta-sheet of 5 strands, order 13245, strand 1 is antiparallel to the rest
68. Pyruvate kinase C-terminal domain-like [52934] (2)
  3 layers: a/b/a; mixed beta-sheet of 5 strands, order 32145, strand 5 is antiparallel to the rest
69. Anticodon-binding domain-like [52953] (4)
  3 layers: a/b/a; mixed beta-sheet of five strands, order 21345; strand 4 is antiparallel to the rest
70. Hypothetical protein MT938 (MTH938) [64075] (1)
  core: 3 layers, b+a/b/a ; the central mixed sheet of 5 strands: order 21534; strand 2 is antiparallel to the rest
71. Restriction endonuclease-like [52979] (3)
  core: 3 layers, a/b/a; mixed beta-sheet of 5 strands, order 12345; strands 2 &, in some families, 5 are antiparallel to the rest
72. Resolvase-like [53040] (2)
  Core: 3 layers: a/b/a; mixed beta-sheet of 5 strands, order 21345; strand 5 is antiparallel to the rest
73. IIA domain of mannose transporter, IIA-Man [53061] (1)
  3 layers: a/b/a; mixed beta-sheet of 5 strands, order 21345; strand 5 is antiparallel to the rest
74. Ribonuclease H-like motif [53066] (7)
  3 layers: a/b/a; mixed beta-sheet of 5 strands, order 32145; strand 2 is antiparallel to the rest
75. Phosphorylase/hydrolase-like [53162] (6)
  core: 3 layers, a/b/a ; mixed sheet of 5 strands: order 21354; strand 4 is antiparallel to the rest; contains crossover loops
76. Molybdenum cofactor biosynthesis proteins [53217] (1)
  3 layers: a/b/a; mixed beta-sheet of 5 strands; order: 21354, strand 5 is antiparallel to the rest; permutation of the Phosphorylase/hydrolase-like fold
77. Hypothetical protein TM1506 [110649] (1)
  3 layers: a/b/a; mixed beta-sheet of five strands, order 21345; strand 1 is antiparallel to the rest
78. Bacterial fluorinating enzyme, N-terminal domain [102521] (1)
  3 layers: a/b/a; mixed beta-sheet of 6 strands; order: 213546, strand 5 is antiparallel to the rest; topological similarity to the MogA-like family fold
79. Caspase-like [52128] (1)
  3 layers, a/b/a; core: mixed beta-sheet of 6 strands, order 213456, strand 6 is antiparallel to the rest
80. Macro domain-like [52948] (1)
  3 layers: a/b/a; mixed beta-sheet of 6 strands, order 165243, strand 3 is antiparallel to the rest
81. MurD-like peptide ligases, peptide-binding domain [53243] (1)
  3 layers: a/b/a; mixed beta-sheet of 6 strands, order 126345; strand 1 is antiparallel to the rest
82. Phosphoglycerate mutase-like [53253] (1)
  core: 3 layers, a/b/a; mixed beta-sheet of 6 strands, order 324156; strand 5 is antiparallel to the rest
83. PRTase-like [53270] (1)
  core: 3 layers, a/b/a; mixed beta-sheet of 6 strands, order 321456; strand 3 is antiparallel to the rest
84. vWA-like [53299] (1)
  core: 3 layers, a/b/a; mixed beta-sheet of 6 strands, order 321456; strand 3 is antiparallel to the rest
85. Pyruvate-ferredoxin oxidoreductase, PFOR, domain III [53322] (1)
  3 layers: a/b/a; mixed beta-sheet of 6 strands, order 231456; strand 3 is antiparallel to the rest
86. Ribose transport protein RbsD [102545] (1)
  3 layers: a/b/a; mixed beta-sheet of 6 strands, order 251634; strand 6 is antiparallel to the rest
87. FabD/lysophospholipase-like [52150] (1)
  core: 3 layers, a/b/a; mixed beta-sheet of 6 strands, order 432156; strand 4 is antiparallel to the rest
88. L-sulfolactate dehydrogenase-like [89732] (1)
  core: 3 layers, a/b/a; mixed sheet of 7 strands, order 1237456; strands 1, 6 and 7 are antiparallel to the rest
89. Formyltransferase [53327] (1)
  3 layers: a/b/a; mixed beta-sheet of 7 strands, order 3214567; strand 6 is antiparallel to the rest
90. S-adenosyl-L-methionine-dependent methyltransferases [53334] (1)
  core: 3 layers, a/b/a; mixed beta-sheet of 7 strands, order 3214576; strand 7 is antiparallel to the rest
91. LmbE-like [102587] (1)
  3 layers, a/b/a; mixed beta-sheet of 7 strands, order 3214576; strand 7 is antiparallel to the rest; topological similarity to SAM-dependent methyltransferases
92. PLP-dependent transferases [53382] (1)
  main domain: 3 layers: a/b/a, mixed beta-sheet of 7 strands, order 3245671; strand 7 is antiparallel to the rest
93. Nucleotide-diphospho-sugar transferases [53447] (1)
  3 layers: a/b/a; mixed beta-sheet of 7 strands, order 3214657; strand 6 is antiparallel to the rest
94. Activating enzymes of the ubiquitin-like proteins [69571] (1)
  3 layers: a/b/a; mixed beta-sheet of 8 strands, order 32145678; strands 6 and 8 are antiparallel to the rest
95. alpha/beta-Hydrolases [53473] (1)
  core: 3 layers, a/b/a; mixed beta-sheet of 8 strands, order 12435678, strand 2 is antiparallel to the rest
96. Nucleoside hydrolase [53589] (1)
  core: 3 layers, a/b/a ; mixed beta-sheet of 8 strands, order 32145687; strand 7 is antiparallel to the rest
97. Dihydrofolate reductases [53596] (1)
  3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest
98. Ribokinase-like [53612] (3)
  core: 3 layers: a/b/a; mixed beta-sheet of 8 strands, order 21345678, strand 7 is antiparallel to the rest
  potential superfamily: members of this fold have similar functions but different ATP-binding sites
99. YjeF N-terminal domain-like [64152] (1)
  3 layers: a/b/a; mixed (mainly parallel) beta-sheet of 8 strands, order 32145678; strand 8 is antiparallel to the rest
100. Carbamate kinase-like [53632] (1)
  3 layers: a/b/a; mixed (mainly parallel) beta-sheet of 8 strands, order 34215786; strand 8 is antiparallel to the rest
101. 2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain [64157] (1)
  core:3 layers: a/b/a; mixed beta-sheet of 8 strands, order 45321678, strands 4 and 5 are antiparallel to the rest
102. Alkaline phosphatase-like [53648] (1)
  core:3 layers: a/b/a; mixed beta-sheet of 8 strands, order 43516728, strand 7 is antiparallel to the rest
103. Hypothetical protein TT1679 [110709] (1)
  3 layers: a/b/a; mixed beta-sheet of 8 strands, order 78612354; strands 3, 4 and 8 are antiparallel to the rest
104. Glycerol-3-phosphate (1)-acyltransferase [69592] (1)
  3 layers: a/b/a; mixed beta-sheet of 9 strands, order 918736452; strands 1, 2 and 8 are antiparallel to the rest
105. AraD-like aldolase/epimerase [53638] (1)
  3 layers: a/b/a; mixed (mostly antiparallel) beta-sheet of 9 strands, order 432159876; left-handed crossover between strands 4 and 5
106. SurE-like [64166] (1)
  3 layers: a/b/a; mixed beta-sheet of 9 strands, order 342156798; strands 3, 8 and 9 are antiparallel to the rest; left-handed crossover connection between strands 6 and 7
107. Isocitrate/Isopropylmalate dehydrogenase-like [53658] (1)
  consists of two intertwined (sub)domains related by pseudo dyad; duplication
  3 layers: a/b/a; single mixed beta-sheet of 10 strands, order 213A945867 (A=10); strands from 5 to 9 are antiparallel to the rest
108. Amidase signature (AS) enzymes [75303] (1)
  possible duplication: the topologies of N- and C-terminal halves are similar; 3 layers: a/b/a; single mixed beta-sheet of 10 strands, order 213549A867 (A=10); strands from 5 to 9 are antiparallel to the rest
109. ATC-like [53670] (2)
  consists of two similar domains related by pseudo dyad; duplication
  core: 3 layers, a/b/a, parallel beta-sheet of 4 strands, order 2134
110. Tryptophan synthase beta subunit-like PLP-dependent enzymes [53685] (1)
  consists of two similar domains related by pseudo dyad; duplication
  core: 3 layers, a/b/a; parallel beta-sheet of 4 strands, order 3214
111. SIS domain [53696] (1)
  3 layers: a/b/a; parallel beta-sheet of 5 strands, order 21345
112. Formate dehydrogenase/DMSO reductase, domains 1-3 [53705] (1)
  contains of two similar intertwined domains related by pseudo dyad; duplication
  core: 3 layers: a/b/a; parallel beta-sheet of 5 strands, order 32451
113. ALDH-like [53719] (1)
  consists of two similar domains with 3 layers (a/b/a) each; duplication
  core: parallel beta-sheet of 5 strands, order 32145
114. Aconitase iron-sulfur domain [53731] (1)
  consists of three similar domains with 3 layers (a/b/a) each; duplication
  core: parallel beta-sheet of 5 strands, order 32145
115. Phosphoglucomutase, first 3 domains [53737] (1)
  consists of three similar domains with 3 layers (a/b/a) each; duplication
  core: mixed beta-sheet of 4 strands, order 2134, strand 4 is antiparallel to the rest
116. L-fucose isomerase, N-terminal and second domains [53742] (1)
  consists of two domains of similar topology, 3 layers (a/b/a) each
  Domain 1 (1-173) has parallel beta-sheet of 5 strands, order 21345
  Domain 2 (174-355) has parallel beta-sheet of 4 strands, order 2134
117. Phosphoglycerate kinase [53747] (1)
  consists of two non-similar domains, 3 layers (a/b/a) each
  Domain 1 has parallel beta-sheet of 6 strands, order 342156
  Domain 2 has parallel beta-sheet of 6 strands, order 321456
118. UDP-Glycosyltransferase/glycogen phosphorylase [53755] (1)
  consists of two non-similar domains with 3 layers (a/b/a) each
  domain 1: parallel beta-sheet of 7 strands, order 3214567
  domain 2: parallel beta-sheet of 6 strands, order 321456
119. Glutaminase/Asparaginase [53773] (1)
  consists of two non-similar alpha/beta domains, 3 layers (a/b/a) each
  Domain 1 has mixed beta-sheet of 6 strands, order 213456, strand 6 is antiparallel to the rest; left-handed crossover connection between strands 4 and 5
  Domain 2 has parallel beta-sheet of 4 strands, order 1234
120. Phosphofructokinase [53783] (1)
  consists of two non-similar domains, 3 layers (a/b/a) each
  Domain 1 has mixed sheet of 7 strands, order 3214567; strands 3 & 7 are antiparallel to the rest
  Domain 2 has parallel sheet of 4 strands, order 2314
121. Tetrapyrrole methylase [53789] (1)
  consists of two non-similar domains
  Domain 1 has parallel sheet of 5 strands, order 32415
  Domain 2 has mixed sheet of 5 strands, order 12534; strands 4 & 5 are antiparallel to the rest
122. GckA/TtuD-like [82543] (1)
  consists of two non-similar domains
  Domain 1 has parallel sheet of 6 strands, order 321456, Rossmann-like topology
  Domain 2 has mixed sheet of 6 strands, order 126345; strands 5 and 6 are antiparallel to the rest; some similarity to CbiF Domain 2
123. DAK1/DegV-like [82548] (1)
  2 different domains; d1: [core: 3 layers, a/b/a; parallel sheet of 5 strands, order: 2134]; D2: [2 layers, a/b; mixed sheet of 6 strands, order 321645; strands 2 and 6 are antiparallel to the rest]
124. DHH phosphoesterases [64181] (1)
  consists of two non-similar domains
  Domain 1 has parallel sheet of 6 strands, order 321456
  Domain 2 has mixed sheet of 5 strands, order 12345; strands 1 & 4 are antiparallel to the rest
125. Glycerate kinase I (Pfam 02595) [110737] (1)
  consists of two different alpha/beta domains; (1) of the Flavodoxin-like fold (scop_cf 52171); (2) similar to the Restriction endonuclease-like fold (scop_cf 52979), inserted into domain 1
126. PEP carboxykinase-like [53794] (1)
  contains a P-loop NTP-binding motif; mixed beta-sheet folds into a barrel-like structure with helices packed on one side
127. PEP carboxykinase N-terminal domain [68922] (1)
  contains mixed beta-sheets; topology is partly similar to that of the catalytic C-terminal domain
128. Chelatase-like [53799] (2)
  duplication: tandem repeat of two domains; 3 layers (a/b/a); parallel beta-sheet of 4 strands, order 2134
129. Uroporphyrinogen III synthase (U3S, HemD) [69617] (1)
  duplication: consists of two similar 'swapped' domain with 3 layers (a/b/a) each; parallel beta-sheet of 5 strands, order 21345
130. Periplasmic binding protein-like I [53821] (1)
  consists of two similar intertwined domain with 3 layers (a/b/a) each: duplication
  parallel beta-sheet of 6 strands, order 213456
131. Periplasmic binding protein-like II [53849] (1)
  consists of two similar intertwined domain with 3 layers (a/b/a) each: duplication
  mixed beta-sheet of 5 strands, order 21354; strand 5 is antiparallel to the rest
132. Thiolase-like [53900] (1)
  consists of two similar domains related by pseudo dyad; duplication
  3 layers: a/b/a; mixed beta-sheet of 5 strands, order 32451; strand 5 is antiparallel to the rest
133. NIF3 (NGG1p interacting factor 3)-like [102704] (1)
  consist of two intertwined domains; duplication: contains two structural repeats of alpha-beta-(beta-alpha)3 motif with mixed beta-sheet, order: 1432, strand 1 is antiparallel to the rest
134. Fe-only hydrogenase [53919] (1)
  consist of two intertwined domains; contains partial duplication
135. CoA-transferase family III (CaiB/BaiF) [89795] (1)
  consist of two different alpha/beta domains; N-terminal domain has a SurE-like topology with a left-handed beta-alpha-beta unit
136. Cytidine deaminase-like [53926] (3)
  core: alpha-beta(2)-(alpha-beta)2; 3 layers (a/b/a); mixed beta-sheet of 4 strands, order 2134; strand 2 is antiparallel to the rest
Alpha and beta proteins (a+b) [53931] (279)
Mainly antiparallel beta sheets (segregated alpha and beta regions)
1. Microbial ribonucleases [53932] (1)
  single helix packs against antiparallel beta-sheet
2. Lysozyme-like [53954] (1)
  common alpha+beta motif for the active site region
3. Cysteine proteinases [54000] (1)
  consists of one alpha-helix and 4 strands of antiparallel beta-sheet and contains the catalytic triad Cys-His-Asn
4. His-Me finger endonucleases [54059] (1)
  core: (alpha)-beta-omega_loop-beta-alpha; embeded in larger different structures
5. RNase A-like [54075] (1)
  contains long curved beta-sheet and 3 helices
6. Prion-like [54097] (1)
  beta-alpha-beta-alpha(2); antiparallel beta-ribbon
7. LysM domain [54105] (1)
  beta-alpha(2)-beta; antiparallel strands
8. Head-to-tail joining protein W, gpW [64209] (1)
  alpha-beta(2)-alpha; antiparallel hairpin
9. Hypothetical protein MTH677 [110782] (1)
  alpha-beta(2)-alpha; 2 layers a/b; antiparallel beta-hairpin
10. Urease, gamma-subunit [54110] (1)
  alpha(3)-beta(2); antiparallel hairpin
11. IL8-like [54116] (1)
  beta(3)-alpha
12. DNA-binding domain [54170] (1)
  beta(3)-alpha; 2 layers: alpha/beta
13. Penicillin-binding protein 2x (pbp-2x), c-terminal domain [54183] (1)
  alpha1-beta3; 2 layers: alpha/beta; order 132
14. Dodecin subunit-like [88797] (3)
  beta-alpha-beta(2); 2 layers: alpha/beta; antiparallel beta-sheet: order 132
15. Ribosomal proteins L23 and L15e [54188] (1)
  beta-(alpha)-beta-alpha-beta(2); 3 layers: alpha/beta/alpha; antiparallel beta-sheet: order 1243
16. Ribosome binding domain-like [100965] (2)
  beta-(2)-alpha(2)-beta(2); 2 layers: beta/alpha; antiparallel beta-sheet: order 1243; topological similarity to the common core of ribosomal proteins L23 and L15e
17. Obg GTP-binding protein C-terminal domain [102740] (1)
  beta-(2)-alpha(3)-beta(2); 2 layers: beta/alpha; mixed beta-sheet: order 1234; strands 2 and 3 a parallel to each other
18. HIT-like [54196] (2)
  alpha-beta(3)-alpha-beta(2); 3 layers: alpha/beta/alpha
19. Secretion chaperone-like [69634] (2)
  alpha-beta(3)-alpha-beta(2)-alpha; 2 layers: alpha/beta
20. DNA-binding domain of intron-encoded endonucleases [64495] (1)
  beta(2)-alpha(2)-beta; 2 layers; 3-stranded antiparallel beta-sheet, order 213; HTH motif; also includes the extra N-terminal, DNA minor groove-binding helix
21. DNA-binding C-terminal domain of the transcription factor MotA [69651] (1)
  alpha-beta(4)-alpha-beta(2)-alpha; 2 layers: alpha/beta
22. Mago nashi protein [89816] (1)
  beta(4)-alpha-beta(2)-alpha; 2 layers: alpha/beta; antiparallel beta-sheet, order: 651234
23. Ribosomal protein S5 domain 2-like [54210] (1)
  core: beta(3)-alpha-beta-alpha; 2 layers: alpha/beta; left-handed crossover
24. beta-Grasp (ubiquitin-like) [54235] (12)
  core: beta(2)-alpha-beta(2); mixed beta-sheet 2143
25. FAD-linked reductases, C-terminal domain [54372] (1)
  alpha+beta sandwich
26. Cystatin-like [54402] (7)
  Core: alpha-beta(4); helix packs against coiled antiparallel beta-sheet
27. Nuclease A inhibitor (NuiA) [82601] (1)
  alpha-beta-alpha-beta-alpha(2)-beta(3); antiparallel beta-sheet; order: 15432
28. Colicin D nuclease domain [102823] (1)
  alpha(2)-beta(4)-alpha, 2 layers: alpha/beta, antiparallel beta sheet, meander
29. Hypothetical protein SAV1430 [110835] (1)
  beta(3)-alpha-beta(2)-alpha; 2 layers, alpha/beta; antiparallel beta-sheet, order: 12543
30. YbaB-like [82606] (1)
  core: alpha-beta(3)-alpha, 2 layers:alpha/beta, three-stranded antiparallel beta sheet, strand order 123
31. Cell division protein ZapA-like [102828] (1)
  core: beta(2)-alpha(2), 2 layers: alpha/beta; long C-terminal helix forms dimeric parallel and tetrameric antiparallel coiled coils
32. ssDNA-binding transcriptional regulator domain [54446] (1)
  helix-swapped dimer of beta(4)-alpha motifs
33. Photosystem I subunit PsaD [64233] (1)
  beta-BETA(2)-beta-alpha-beta(2); antiparallel sheet: order 2134 packed against helix and BETA-hairpin on the same side; irregular C-terminal tail
34. MHC antigen-recognition domain [54451] (1)
  dimeric
35. UBC-like [54494] (1)
  alpha-beta(4)-alpha(3); core: meander beta-sheet plus one helix 2
36. SAND domain-like [63762] (1)
  core: three short helices packed against a barrel-like beta-sheet; some similarity to the SH3-like fold
37. ParB/Sulfiredoxin [110848] (1)
  beta*-alpha-beta(2)-alpha-beta-alpha; mixed beta sheet forms a partly open barrel: (n*=4, S*=8)
38. BtrG-like (Pfam 03674) [110856] (1)
  beta-alpha-beta(4)-alpha-beta(2); contains beta-sheet barrel (n=5, S=8)
39. NSFL1 (p97 ATPase) cofactor p47, SEP domain [102847] (1)
  beta(3)-alpha(2)-beta; 2 layers; mixed beta-sheet, order 4123, strands 1 and 4 are parallel to each other
40. Diaminopimelate epimerase-like [54505] (1)
  mixed beta-sheet folds into a barrel (n=8, S=14) around the central helix
41. GFP-like [54510] (1)
  beta-sheet folds into a barrel (n=11, S=14) around the central helix
42. Transcriptional factor tubby, C-terminal domain [54517] (1)
  beta-sheet folds into a barrel (n=12, S=12) around the central helix
43. Pili subunits [54522] (1)
  contains very long N-terminal helix, which end is packed against beta-sheet
44. Acidic mitochondrial matrix protein p32 [54528] (1)
  core: beta(7)-alpha(2); N- and C-terminal extensions form a coiled coil subdomain
45. Polo-box domain [82614] (1)
  beta(6)-alpha; antiparallel beta-sheet, meander
46. mRNA decapping enzyme DcpS N-terminal domain [102859] (1)
  beta(3)-alpha-beta(3)-alpha; 3 layers a/b/a
47. Inhibitor of vertebrate lysozyme, Ivy [89871] (1)
  alpha(2)-beta(5)-alpha(2); 3 layers a/b/a; meander beta-sheet
48. FKBP-like [54533] (3)
  core: beta(2)-alpha-beta(2); antiparallel beta-sheet
49. Ribosomal protein S16 [54564] (1)
  beta(4)-alpha-beta; 2 layers: alpha/beta; mixed beta-sheet, order: 51234
50. Ribosomal protein S19 [54569] (1)
  alpha-beta-X-beta(2); 2 layers: alpha/beta; mixed beta-sheet, order: 123
51. Ribosomal protein L31e [54574] (1)
  beta-alpha-beta-(alpha)-beta(2); 2 layers: alpha/beta; mixed beta-sheet, order: 1342
52. Allophycocyanin linker chain (domain) [54579] (1)
  beta(2)-alpha-beta; 2 layers: alpha/beta
53. Cdc48 domain 2-like [54584] (1)
  beta-alpha-beta(3); 2 layers: alpha/beta
54. Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase [54592] (1)
  beta-alpha-beta(3); 2 layers: alpha/beta
55. Chromosomal protein MC1 [102874] (1)
  beta(2)-alpha-beta(3); 2 layers: alpha/beta
56. beta-hairpin-alpha-hairpin repeat [74651] (2)
  multiple repeats of beta(2)-alpha(2) motif
57. Proguanylin [89889] (1)
  beta(2)-alpha(3)-beta; two layers: alpha/beta; antiparallel sheet: order 213
58. Bacterial protein-export protein SecB [54610] (1)
  beta(4)-alpha(2); two layers: alpha/beta; antiparallel sheet: order 1432
59. FYSH domain [89894] (1)
  beta(2)-alpha(2)-beta(2)-alpha-beta; two layers: alpha/beta; antiparallel sheet: order 51234
60. VSV matrix protein [75403] (1)
  beta-alpha(2)-beta(4)-alpha-beta(2); two layers: alpha/beta; bifurcated coiled beta-sheet: order of the first 5 strands: 23154
61. DNA-binding domain of Mlu1-box binding protein MBP1 [54615] (1)
  beta(4)-alpha(2)-beta(2)-alpha; antiparallel sheet: order 123465
62. Heme-binding protein A (HasA) [54620] (1)
  beta-alpha-beta(6)-alpha(2); antiparallel sheet: order 165432
63. Chalcone isomerase [54625] (1)
  beta(3)-alpha(2)-beta-alpha(2)-beta3; 2 layers alpha/beta; antiparallel sheet: order 1234567
64. Coproporphyrinogen III oxidase [102885] (1)
  alpha-beta(6)-alpha(2)-beta-alpha(n); 3 layers alpha/beta/alpha; antiparallel sheet: order 1234567
65. Hypothetical protein Ta1206 [102890] (1)
  beta(4)-alpha-beta(2)-alpha(2); mixed, predominately antiparallel beta-sheet, order: 123465, strands 4 and 5 are parallel to each other
66. CBS-domain [54630] (1)
  core: beta-alpha-beta(4); 2 layers: alpha/beta
67. Thioesterase/thiol ester dehydrase-isomerase [54636] (1)
  core: beta-alpha-beta(4); 2 layers: alpha/beta
68. DLC [54647] (1)
  core: beta-alpha(2)-beta-X-beta(2); 2 layers: alpha/beta; antiparallel beta-sheet: order 1342
69. CI-2 family of serine protease inhibitors [54653] (1)
  alpha+beta sandwich; loop across free side of beta-sheet
70. Integrin beta tail domain [69686] (1)
  alpha-beta-loop-beta(3); loop across free side of beta-sheet
71. alpha/beta-Hammerhead [54664] (5)
  core: beta-BETA-alpha-beta-BETA-beta-alpha; contains a beta-hammerhead motif similar to that in barrel-sandwich hybrids
72. POZ domain [54694] (1)
  core: beta(2)-alpha(2)-beta(2)-alpha(2); 2 layers a/b; mixed sheet: 2143
73. Elongation factor Ts (EF-Ts), dimerisation domain [54712] (1)
  beta(2)-alpha(n)-beta; 2 layers a/b; antiparallel sheet: 123
74. Fe,Mn superoxide dismutase (SOD), C-terminal domain [54718] (1)
  alpha-beta(2)-alpha-beta-alpha(2); 3 strands of antiparallel sheet: 213
75. ClpS-like [54735] (1)
  beta-alpha(2)-beta-alpha-beta; 2 layers, alpha/beta
76. Hypothetical protein MTH1880 [75411] (1)
  beta-alpha-beta(2)-alpha(2); 3 layers, alpha/beta/alpha; antiparallel beta-sheet: order 123
77. Ribosomal protein L11, N-terminal domain [54746] (1)
  beta-alpha(2)-beta(2); 2 layers, alpha/beta; antiparallel beta-sheet: order 123
78. Anti-LPS factor/recA domain [54751] (2)
  alpha-beta(3)-alpha(2); 2 layers, alpha/beta
79. Signal recognition particle alu RNA binding heterodimer, SRP9/14 [54761] (1)
  (beta)-alpha-beta(3)-alpha; 2 layers, alpha/beta
80. dsRBD-like [54767] (4)
  alpha-beta(3)-alpha; 2 layers: alpha/beta
81. 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain [110920] (1)
  duplication: consists of two beta(3)-alpha repeats; 3 layers, beta/alpha/beta
82. SRP19 [69694] (1)
  beta-alpha-beta(2)-alpha; 2 layers: alpha/beta
83. SufE/NifU [82648] (1)
  alpha(2)-beta(3)-alpha(3); 2 layers alpha/beta, 3-stranded antiparallel beta-sheet; order 123
84. DNA-binding protein Tfx [89914] (1)
  alpha(3)-beta-alpha(2)-beta(2); 2 layers alpha/beta, 3-stranded antiparallel beta-sheet; order 123
85. Eukaryotic type KH-domain (KH-domain type I) [54790] (1)
  beta-alpha(2)-beta(2)-alpha; 2 layers: alpha/beta
86. Alpha-lytic protease prodomain-like [54805] (7)
  core: alpha-beta(2)-(alpha)-beta; 2 layers: alpha/beta
87. Nucleotidyltransferase [81302] (1)
  core: alpha-beta-turn-beta-X-beta-(alpha); mixed beta-sheet, order of core strands: 123
88. Ribosomal protein S3 C-terminal domain [54820] (1)
  alpha(2)-beta(4); 2 layers: alpha/beta; antiparallel beta-sheet: order 2143
89. Transcription factor NusA, N-terminal domain [69704] (1)
  alpha-beta(3)-alpha-beta-alpha; bifurcated coiled beta-sheet
90. Enolase N-terminal domain-like [54825] (1)
  beta(3)-alpha(3); meander and up-and-down bundle
91. Ribosomal protein L22 [54842] (1)
  beta-alpha(3)-beta(2); 2 layers: alpha/beta; related to the enolase/MLE N-domain fold by a circular permutation
92. Prokaryotic ribosomal protein L17 [64262] (1)
  alpha-beta-alpha(3)-beta(2); 2 layers: alpha/beta;
93. GroEL-intermediate domain like [54848] (1)
  3-helical bundle packed against 3-stranded mixed beta-sheet
94. PX domain [64267] (1)
  beta(3)-alpha(4); meander beta-sheet packed against array of helices; contains Pro-rich stretch
95. DsrC, the gamma subunit of dissimilatory sulfite reductase [69720] (1)
  beta(3)-alpha(5); meander beta-sheet packed against array of helices
96. DNA damage-inducible protein DinI [54856] (1)
  beta-alpha-beta(2)-alpha; 2 layers: alpha/beta; mixed sheet 213; crossing loops
97. HSP90 C-terminal domain (C-terminal part of Pfam 00183) [110941] (1)
  alpha-beta(3)-alpha(3); 2 layers, a/b; mixed beta-sheet, order:132; crossing loops
98. Ferredoxin-like [54861] (49)
  alpha+beta sandwich with antiparallel beta-sheet; (beta-alpha-beta)x2
99. PurS-like [109622] (1)
  consists of two alpha+beta subdomains with some similarity to the ferredoxin-like fold
100. Dystroglycan, domain 2 [111005] (1)
  beta-alpha-beta-X-beta(2)-alpha(2)-beta; antiparallel beta-sheet, order 24153; topological similarity to the ferredoxin-like fold (scop_cf 54861)
101. Pseudouridine synthase [100877] (1)
  consists of two alpha+beta subdomains with some similarity to the ferredoxin-like fold
102. Aminomethyltransferase folate-binding domain [103024] (1)
  duplication: consists of two beta(2)-alpha-beta(3)-alpha subdomains swapped with the first strands
103. Hypothetical protein YwqG [103031] (1)
  duplication: contains two similar beta-x-beta(4) motifs swapped with the first strands
104. Lesion bypass DNA polymerase (Y-family), little finger domain [100878] (1)
  beta-alpha-beta(2)-alpha-beta; antiparallel beta-sheet: order 1423; "reversed" ferredoxin-like topology
105. Ribosomal protein L30p/L7e [55128] (1)
  core: beta-alpha-beta-alpha-beta; antiparallel beta-sheet: order 312; some similarity to the ferredoxin-like fold
106. Chorismate lyase [64287] (1)
  duplication of alpha(2)-beta(3) motif; antiparallel beta sheet, order 123654
107. Probable bacterial effector-binding domain [55135] (1)
  duplication of beta-alpha-beta(2) motif: antiparallel beta sheet forms barrel (n=6, S=12)
108. CheC-like [103038] (1)
  duplication: tandem repeat of two intertwined alpha-beta-(BETA)-beta(2) motifs; dimer
109. LigT-like [55143] (1)
  duplication of beta-alpha-beta-alpha-beta motif: antiparallel beta sheet forms barrel (n=6, S=8) similar to the barrel of prokaryotic DNA topoisomerases I and III
110. Pepsin inhibitor-3 [55148] (1)
  duplication of beta(3)-alpha(2) motif: meander beta sheets form barrel-like structure
111. mRNA triphosphatase CET1 [55153] (1)
  duplication of beta-alpha-beta(3) motif: antiparallel beta sheet forms wide barrel (n=8, S=16) with a channel running through it
112. eIF1-like [55158] (1)
  beta(2)-alpha-beta(2)-alpha-beta; 2 layers: alpha/beta; mixed beta-sheet: order 51243
113. Hedgehog/DD-peptidase [55165] (1)
  alpha-beta(2)-alpha-beta(2); 2 layers: alpha/beta
114. Alpha-L RNA-binding motif [55173] (1)
  alpha(2)-beta(2)-loop-beta; 2 layers: alpha/beta
115. RRF/tRNA synthetase additional domain-like [55185] (4)
  core: alpha-beta(2)-alpha-beta(2); 2 layers: alpha/beta
116. LuxS/MPP-like metallohydrolase [63410] (1)
  core: beta-alpha-beta(2)-alpha(2); 2 layers: alpha/beta
117. IF3-like [55199] (7)
  beta-alpha-beta-alpha-beta(2); 2 layers; mixed sheet 1243, strand 4 is antiparallel to the rest
118. Ribosome binding protein Y (YfiA homologue) [69753] (1)
  beta-alpha-beta(3)-alpha; 2 layers; mixed sheet 1234, strand 3 is antiparallel to the rest
119. TolA/TonB C-terminal domain [74652] (1)
  beta(2)-alpha-beta; 2 layers, alpha/beta; left-handed beta-alpha-beta unit in non-swapped monomer
120. Yeast killer toxins [55220] (1)
  beta-alpha-beta(2)-alpha-beta(2); 2 layers, alpha/beta; left-handed crossover connection
121. Cell division protein MinE topological specificity domain [55228] (1)
  dimer of alpha-beta(2) motifs ; 2 layers, alpha/beta
122. Hypothetical protein YoaG [103062] (1)
  dimer of beta(2)-alpha motifs ; 2 layers, alpha/beta; reverse MinE topology
123. Arterivirus nucleocapsid protein [103067] (1)
  dimer of alpha-beta(2)-alpha motifs ; 2 layers, alpha/beta
124. Cyanase C-terminal domain [55233] (1)
  intertwined dimer of alpha-beta(2) motifs ; 2 layers, alpha/beta
125. Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains [82713] (1)
  Intertwined pseudo hexamer of an alpha+beta motif
126. RuBisCO, small subunit [55238] (1)
  alpha-beta(2)-alpha-beta(2); 2 layers, alpha/beta
127. DCoH-like [55247] (4)
  beta(2)-alpha-beta(2)-alpha; 2 layers, alpha/beta
128. Hypothetical protein Yml108w [100886] (1)
  beta(2)-alpha-beta(2)-alpha; 2 layers, alpha/beta; mixed beta-sheet 2143, strands 1 and 4 are parallel
129. MutS N-terminal domain-like [55266] (2)
  beta(2)-alpha-beta(2)-alpha-beta(2); 2 layers, alpha/beta
130. GYF domain [55276] (1)
  beta(2)-alpha-beta(2)-alpha; 2 layers, alpha/beta
131. GTP cyclohydrolase I feedback regulatory protein, GFRP [69760] (1)
  beta(2)-alpha-beta(2)-alpha-beta(2); 2 layers, alpha/beta, antiparallel beta-sheet: order 342165
132. Ribosomal protein L5 [55281] (1)
  beta-alpha-beta(2)-alpha-beta(3)-alpha; 2 layers, alpha/beta; antiparallel beta-sheet: order 231654
133. RPB5-like RNA polymerase subunit [55286] (1)
  core: beta-alpha-beta-alpha-beta(2); 2 layers, alpha/beta
134. Bacillus chorismate mutase-like [55297] (7)
  core: beta-alpha-beta-alpha-beta(2); mixed beta-sheet: order: 1423, strand 4 is antiparallel to the rest
135. YjbQ-like (Pfam 01894) [111037] (1)
  beta(2)-alpha-beta(2)-alpha(2)-beta(3); contains a beta-sandwich: 7 strands in 2 sheets; trimerizes with orthogonally packed beta-sheets
136. Tautomerase/MIF [55330] (1)
  (beta-alpha-beta)2; 2 layers: alpha/beta; mixed beta-sheet
  generally forms trimers with three closely packed beta-sheets
137. Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain [55346] (1)
  core: alpha-beta-alpha-beta(3); mixed sheet: 2134, strand 2 is parallel to strand 1
138. Hypothetical protein PF0899 [111056] (1)
  alpha-beta-alpha-beta(4); 2 layers: a/b; mixed beta-sheet, order 23145, strands 1 and 3 are parallel; similar to the GAPDH C-terminal domain-like fold (scop_cf 55346)
139. N domain of copper amine oxidase-like [55382] (3)
  alpha-beta(5)-alpha; 2 layers: alpha/beta; meander antiparallel sheet
140. Aha1/BPI domain-like [55393] (2)
  core: [beta]-alpha-beta(5)-alpha; 2 layers: alpha/beta; antiparallel beta-sheet, meander
141. Subtilisin inhibitor [55398] (1)
  alpha+beta sandwich
142. RNA bacteriophage capsid protein [55404] (1)
  6-standed beta-sheet followed with 2 helices; meander
143. Translation initiation factor eIF4e [55417] (1)
  beta(2)-alpha-beta(2)-alpha-beta(2)-alpha-beta-2; 2 layers: alpha/beta; antiparallel sheet: 21356478
144. CO dehydrogenase flavoprotein C-domain-like [55423] (2)
  core: beta(3,4)-alpha(3); alpha+beta sandwich
145. SRF-like [55454] (1)
  alpha-beta(2)-alpha; dimer; 3 layers a/b/a; antiparallel beta-sheet
146. Origin of replication-binding domain, RBD-like [55463] (1)
  alpha-beta-alpha-beta(2)-alpha-beta-alpha-beta; 3 layers: a/b/a; antiparallel sheet 41325
147. Hut operon positive regulatory protein HutP [111063] (1)
  alpha(2)-beta-alpha(2)-beta(3); 3 layers: a/b/a; antiparallel beta-sheet: order 1234
148. Hypothetical protein yfbM [111068] (1)
  beta-alpha(2)-beta-alpha(2)-beta(2)-alpha(n)-beta; 3 layers: a/b/a; antiparallel beta-sheet, order: 21543
149. Bacillus phage protein [111073] (1)
  alpa-beta(3)-alpha-beta(3)-alpha; 3 layers: b/a/b, 3-helical bundle flanked by two 3-stranded meander beta-sheets
150. FMN-dependent nitroreductase-like [55468] (1)
  core: (alpha-beta-alpha-beta)2; 3 layers a/b/a; antiparallel beta-sheet: 1243
151. N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1 [55480] (1)
  alpha-beta-alpha(2)-beta(3)-alpha; 3 layers a/b/a; antiparallel beta-sheet: 4123
152. Zincin-like [55485] (2)
  contains mixed beta sheet with connection over free side of the sheet
153. SH2-like [55549] (1)
  3 layers: a/b/a; antiparallel beta-sheet of 5 strands is flaked by two helices
154. HPr-like [55593] (2)
  beta-alpha-beta(2)-alpha-beta-alpha; 2 layers: a/b; antiparallel sheet 1423
155. Hypothetical protein YjiA, C-terminal domain [90001] (1)
  beta-alpha-beta(4)-alpha; 2 layers: a/b; antiparallel sheet 15234; topological similarity to the HPr-like fold
156. YggU-like [69785] (1)
  beta(2)-loop-alpha-beta(2)-alpha; 2 layers: a/b; antiparallel sheet 1243; some similarity to the Homing endonuclease-like fold
157. Homing endonuclease-like [55603] (2)
  alpha-beta(2)-alpha-beta(2)-alpha; 2 layers: a/b; antiparallel sheet 1243
158. T-fold [55619] (1)
  beta(2)-alpha(2)-beta(2); 2 layers: alpha/beta; antiparallel sheet 1234
  tunnel-shaped: its known members form wide oligomeric barrels different sizes
159. Cell cycle regulatory proteins [55636] (1)
  beta(2)-alpha(2)-beta(2); 2 layers: alpha/beta; antiparallel sheet 1243
  can form strand-exchange dimers
160. beta-lactamase-inhibitor protein, BLIP [55647] (1)
  alpha(2)-beta(4); 2 layers: alpha/beta
161. Ribosomal protein L9 C-domain [55652] (1)
  alpha-beta-alpha(2)-beta(2); 2 layers: alpha/beta
162. L9 N-domain-like [55657] (1)
  beta(2)-alpha-beta-alpha; 3 layers: alpha/beta/alpha
163. Tombusvirus P19 core protein, VP19 [103144] (1)
  beta(2)-alpha-beta(2)-alpha; 2 layers: alpha/beta; antiparallel sheet: order 2134
164. Ribonuclease PH domain 2-like [55665] (1)
  beta(2)-alpha-beta(2)-alpha; 3 layers: alpha/beta/alpha; antiparallel sheet: order 2134
165. Regulatory factor Nef [55670] (1)
  alpha(2)-beta(4)-alpha; 3 layers: alpha/beta/alpha
166. CytB endotoxin-like (Pfam 01338) [55675] (1)
  core: beta-alpha(2)-beta-alpha(2)-beta(4); 3 layers: a/b/a
167. Class II aaRS and biotin synthetases [55680] (1)
  contains large mixed beta-sheet
168. Subdomain of clathrin and coatomer appendage domain [55710] (1)
  beta-alpha-beta-alpha-beta(4)-alpha; 3 layers: a/b/a; bifurcated antiparallel beta-sheet
169. Sterol carrier protein, SCP [55717] (1)
  alpha-beta(3)-(crossover)-beta-(alpha)-beta; 3 layers: a/b/a; antiparallel beta-sheet of 5 strands; order: 32145
170. Hypothetical protein Ta1353 [103164] (1)
  core: beta-alpha-beta(2)-alpha-beta-alpha-beta; 3 layers: a/b/a; antiparallel beta-sheet of 5 strands; order: 51423;
171. Mog1p/PsbP-like [55723] (1)
  (beta-hairpin)-beta(3)-alpha-beta(4)-alpha; 3 layers: a/b/a; antiparallel beta-sheet of 7 strands; order: 1237654
172. Acyl-CoA N-acyltransferases (Nat) [55728] (1)
  3 layers: a/b/a; contains mixed beta-sheet
173. Gelsolin-like [55752] (2)
  3 layers: a/b/a; contains mixed beta-sheet
174. Profilin-like [55769] (7)
  core: 2 alpha-helices and 5-stranded antiparallel sheet: order 21543; 3 layers: alpha/beta/alpha
175. H-NOX domain [111125] (1)
  binds heme between the N-terminal 4-helical bundle and the C-terminal alpha-beta(2)-alpha-beta(2) subdomains
176. PR-1-like [55796] (1)
  alpha-beta-alpha-beta-alpha(2)-beta(2); 3 layers, alpha/beta/alpha; mixed sheet: order 1342
177. Phoshotransferase/anion transport protein [55803] (1)
  beta-alpha(2)-beta(3)-alpha(3); 3 layers, alpha/beta/alpha; mixed sheet: order 1342; loop crossing
178. Nudix [55810] (1)
  beta(2)-alpha-beta(3)-alpha; 3 layers: alpha/beta/alpha; mixed sheet
  contains beta-grasp motif
179. 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain [55815] (1)
  core: alpha-beta(2)-alpha-beta(2)-alpha-beta; 3 layers; mixed sheet: order 31425
180. YrdC/RibB [55820] (1)
  core: alpha-beta(2)-alpha-beta-alpha(2)-beta(2)-alpha-beta-alpha-beta; 3 layers; mixed twisted sheet of 7 strands; order 7126354; strands 7 and 1 are parallel to each other
181. GIY-YIG endonuclease [82770] (1)
  beta(2)-alpha(2)-beta-alpha-(beta); strand 4 is very short; 3 layers; antiparallel (mixed) beta-sheet; order 312(4)
182. YbaK/ProRS associated domain [55825] (1)
  core: alpha-beta-alpha-beta(2)-(alpha-beta)2-alpha-beta(2)-alpha-beta; 3 layers; bifurcated mixed sheet
183. Thymidylate synthase/dCMP hydroxymethylase [55830] (1)
  contains large mixed beta-sheet
184. Thymidylate synthase-complementing protein Thy1 [69795] (1)
  complex alpha+beta fold; contains antiparallel 5-stranded beta-sheet: order 12354
185. N-acetylmuramoyl-L-alanine amidase-like [55845] (1)
  contains mixed beta-sheet
186. Cytochrome b5-like heme/steroid binding domain [55855] (1)
  beta-alpha-beta(2)-alpha(1,2)-(beta)-alpha(2)-beta; 3 layers: a/b/a; antiparallel beta-sheet, order: 1532(4)
187. DNA topoisomerase I domain [55868] (1)
  beta(2)-alpha-beta-(alpha)-beta(2); left-handed crossover between strands 2 & 3
188. ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [55873] (1)
  8-stranded mixed beta-sheet; 2 layers: alpha/beta
189. Sporulation response regulatory protein Spo0B [55889] (1)
  core: alpha-beta-alpha-beta(2)-(alpha)-beta(2)
190. Ribonuclease Rh-like [55894] (1)
  alpha+beta fold
191. YlxR-like [64375] (1)
  alpha+beta fold; could have evolved from a glucocorticoid receptor-like zinc finger domain
192. YggX-like (Pfam 04362) [111147] (1)
  beta(2)-alpha(3); contains zinc-less 'zinc finger'-like fold (scop_cf 57715; see also scop_cf 64375)
193. Ornithine decarboxylase C-terminal domain [55903] (1)
  complex alpha+beta motif
194. Pentein, beta/alpha-propeller [55908] (1)
  duplication: composed of 5 alpha-beta(2)-alpha-beta units arranged around pseudo fivefold axis
195. Creatinase/aminopeptidase [55919] (1)
  duplication: composed of two very similar alpha+beta folds
196. Glutamine synthetase/guanido kinase [55930] (1)
  duplication: common core consists of two beta-alpha-beta2-alpha repeats
197. TBP-like [55944] (8)
  beta-alpha-beta(4)-alpha
198. S-adenosylmethionine synthetase [55972] (1)
  duplication: consists of 3 similar intertwined domains
  structural repeat: beta-alpha-beta(2)-alpha-beta; two layers, alpha/beta
199. DNA clamp [55978] (1)
  contains two helices and two beta sheets
  duplication: fold has internal pseudo two-fold symmetry
200. Hypothetical protein TM0160 [103255] (1)
  duplication: consists of two beta(3)-alpha(2) structural repeats; single barrel-like beta-sheet
201. Molybdenum cofactor-binding domain [56002] (1)
  beta(2)-alpha-beta-alpha-beta; 2 layers: a/b; mixed sheet: order 1243: crossing loops
202. Sulfite reductase hemoprotein (SiRHP), domains 2 and 4 [56013] (1)
  beta-alpha-beta-alpha-beta(3)-alpha(2,3); mixed sheet: order 12345; left-handed crossover connection between strands 1 and 2
203. The spindle assembly checkpoint protein mad2 [56018] (1)
  core: alpha(2)-beta(2)-alpha-beta; mixed sheet: order 213
204. Phospholipase D/nuclease [56023] (1)
  beta-alpha-beta-alpha-beta-alpha-beta(4)-alpha; mixed sheet: order 1765234
205. Monooxygenase (hydroxylase) regulatory protein [56028] (1)
  corner-like structure formed by two sheets and filled in with 2-3 helices
206. B3/B4 domain of PheRS, PheT [56036] (1)
  3 layers: beta/beta/alpha sandwich
207. PurM C-terminal domain-like [56041] (1)
  3 layers: alpha/beta/alpha; partial topological similarity to the ferredoxin-like fold
208. Chorismate synthase, AroC [103262] (1)
  duplication: consists of two DCoH-like beta(2)-alpha-beta(2)-alpha structural repeats; 3 layers, beta/alpha/beta
209. Hsp33 domain [64396] (1)
  3 layers: beta/alpha/beta; buried helix
210. MTH1598-like [69818] (1)
  beta(2)-alpha-beta-alpha-beta(4); 3 layers: beta/alpha/beta; some similarity to the Hsp33 fold
211. Protein-L-isoaspartyl O-methyltransferase, C-terminal domain [68929] (1)
  beta-alpha-beta(4)-alpha-beta(2); 3 layers: beta/alpha/beta; buried helix
212. OsmC-like [82783] (1)
  swapped dimer of beta(3)-alpha-beta(2)-alpha(2)-beta subunits; mixed beta-sheet; order: 321[4][5][6]; buried helix
213. Hypothetical protein HI1480 [103276] (1)
  beta-alpha(4)-beta-alpha-beta; segregated alpha-helical and beta-sheet subdomains; dimeric beta-sheet barrel: n=6, S=10
214. Ribosomal protein S8 [56046] (1)
  consists of 2 different alpha+beta subdomains arranged in a 4-layer structure: b/a/b/a
215. Ribosomal protein L6 [56052] (1)
  consists of two beta-sheets and one alpha-helix packed around single core
216. Smc hinge domain [75552] (1)
  consists of 2 different alpha+beta subdomains; forms subdomain-swapped dimers
217. ATP-grasp [56058] (2)
  Consists of two subdomains with different alpha+beta folds
  shares functional and structural similarities with the PIPK and protein kinase superfamilies
218. SAICAR synthase-like [56103] (1)
  consists of two alpha+beta subdomains
219. Protein kinase-like (PK-like) [56111] (1)
  consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
220. FAD-binding domain [56175] (1)
  consists of two alpha+beta subdomains
221. Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain [56193] (1)
  consists of two alpha+beta subdomains
222. Methenyltetrahydromethanopterin cyclohydrolase [56198] (1)
  consists of two alpha+beta subdomains
223. Prim-pol domain [56746] (1)
  consists of two alpha+beta domains
224. Hect, E3 ligase catalytic domain [56203] (1)
  consists of two alpha+beta domains; the N-terminal domain is array of helices and beta-hairpins; the C-terminal domain is an a/b sandwich with one left-handed beta-alpha(n)-beta unit; conformational flexibility of domain orientation
225. Nitrile hydratase alpha chain [56208] (1)
  4 layers a/b/b/a; inside is a sandwich of two 2-stranded beta-sheets
226. 4'-phosphopantetheinyl transferase [56213] (1)
  beta-alpha(3)-beta(2) motif
227. DNase I-like [56218] (1)
  contains beta-sandwich; duplication of alpha+beta motif
228. Aldehyde ferredoxin oxidoreductase, N-terminal domain [56227] (1)
  contains sandwich; duplication of alpha+beta motif with single mixed sheet
  motif: beta(2)-alpha-beta(3)-alpha-beta; strand order 216345, strands 1 and 6 are parallel
229. Ntn hydrolase-like [56234] (2)
  4 layers: alpha/beta/beta/alpha; has an unusual sheet-to-sheet packing
230. DmpA/ArgJ-like [56265] (1)
  duplication of beta(3)-alpha-beta-alpha motif; 4 layers: alpha/beta/beta/alpha
231. Pyruvoyl-dependent histidine and arginine decarboxylases [56270] (1)
  duplication of beta-alpha-beta(2) motif; 4 layers: alpha/beta/beta/alpha; contains "silk" beta-sandwich
232. S-adenosylmethionine decarboxylase [56275] (1)
  duplication of beta-alpha-beta(4)-alpha-beta-alpha-beta(2) motif; 4 layers a/b/b/a; antiparallel beta-sheets: order 23451687
233. Metallo-hydrolase/oxidoreductase [56280] (1)
  duplication of beta(4)-alpha-beta-alpha motif; 4 layers a/b/b/a; mixed beta-sheets
234. Protein serine/threonine phosphatase 2C, catalytic domain [81607] (1)
  4 layers: alpha/beta/beta/alpha; antiparallel beta sheets
235. Metallo-dependent phosphatases [56299] (1)
  4 layers: alpha/beta/beta/alpha; mixed beta sheets; contains duplication
236. Carbon-nitrogen hydrolase [56316] (1)
  4 layers: alpha/beta/beta/alpha; mixed beta sheets; contains duplication
237. CNF1/YfiH-like putative cysteine hydrolases [64437] (1)
  4 layers: alpha/beta/beta/alpha; mixed beta sheets
238. ADC synthase [56321] (1)
  duplication: contains four repeats of alpha-beta(2)-beta motif arranged in a 4 layer core structure: alpha/beta/beta/alpha; orthogonally packed beta-sheets
239. Sulfolobus fructose-1,6-bisphosphatase-like [111248] (1)
  4 layers: a/b/b/a; antiparallel beta sheets; similarities to ferredoxin-like fold (scop_cf 54861) in the N-terminal part (1-120) and to the Bacterial S-adenosylmethionine decarboxylase subunit (scop_fa 997656) in the C-terminal part (121-340)
240. LDH C-terminal domain-like [56326] (1)
  unusual fold, defines family
241. DNA breaking-rejoining enzymes [56348] (1)
  core: alpha3-beta3-alpha4; one side of beta-sheet is exposed
242. Replication modulator SeqA, C-terminal DNA-binding domain [82807] (1)
  consists of seven alpha-helices and three-stranded beta-sheet
243. SMAD MH1 domain [56365] (1)
  consists of four alpha-helices and three beta-ribbons
244. YopH tyrosine phosphatase N-terminal domain [64448] (1)
  consists of four alpha-helices and two beta-hairpins
245. Rotavirus NSP2 fragment, N-terminal domain [75573] (1)
  consists of six alpha-helices and two beta-hairpins
246. Ribosome inactivating proteins (RIP) [56370] (1)
  contains mixed beta-sheet
247. ADP-ribosylation [56398] (1)
  unusual fold
248. Peptide deformylase [56419] (1)
  alpha-beta(5)-alpha; 3 layers: a/b/a; meander beta-sheet wraps around the C-terminal alpha-helix
249. LCCL domain [69847] (1)
  unusual fold
250. Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain [56424] (1)
  unusual fold
251. C-type lectin-like [56435] (1)
  unusual fold
252. Hemolytic lectin CEL-III, C-terminal domain [111264] (1)
  unusual fold
253. SRCR-like [56486] (2)
  unusual fold; disulfide-rich; core: beta-x-alpha-beta-loop-beta
254. Fibrinogen C-terminal domain-like [56495] (1)
  unusual fold
255. gp120 core [56501] (1)
  unusual fold
256. Methionine synthase activation domain-like [56506] (1)
  unusual fold; core: beta-alpha(2)-beta(2)-alpha(2)-beta-alpha-beta; antiparallel beta-sheet: order 12354
257. Hypothetical protein TM0875 [90063] (1)
  unusual fold; core: beta(2)-loop-beta(2)-alpha-beta; mixed beta-sheet: order 51243; parallel strands 2 and 4
258. Metal cation-transporting ATPase, ATP-binding domain N [81661] (1)
  unusual fold; core: beta-alpha(2)-beta(3)-alpha(2)-beta(2); 6-stranded antiparallel beta-sheet, order: 165432
259. Suppressor of Fused, N-terminal domain [103358] (1)
  unusual fold; bifurcated beta-sheet; left-handed beta-alpha-beta unit
260. Nitric oxide (NO) synthase oxygenase domain [56511] (1)
  unusual fold
261. Penicillin binding protein dimerisation domain [56518] (1)
  unusual fold
262. Sulfite oxidase, middle catalytic domain [56523] (1)
  unusual fold; contains 3 layers of beta-sheet structure and a beta-grasp like motif
263. FAH [56528] (1)
  unusual fold; contains 3 layers of beta-sheet structure
264. Aromatic aminoacid monoxygenases, catalytic and oligomerization domains [56533] (1)
  unusual fold
265. Substrate-binding domain of HMG-CoA reductase [56541] (1)
  unusual fold
266. Argininosuccinate synthetase, C-terminal domain [69863] (1)
  unusual fold
267. Hypothetical protein PH1602 [103364] (1)
  complex alpha+beta fold; contains a region of similarity to the ferredoxin-like fold
268. Putative cell cycle protein MesJ, middle and C-terminal domain [82828] (1)
  consists of two different alpha+beta domains
269. GCM domain [90072] (1)
  consists of two different alpha+beta subdomains; 2 zinc-binding sites
270. Conserved core of transcriptional regulatory protein vp16 [56547] (1)
  unusual fold
271. Insert subdomain of RNA polymerase alpha subunit [56552] (1)
  unusual fold; contains a left-handed beta-alpha-beta unit
272. Baseplate structural protein gp11 [56557] (1)
  unusual fold; trimer
273. Receptor-binding domain of short tail fibre protein gp12 [88873] (1)
  unusual fold; trimer
274. Major capsid protein gp5 [56562] (1)
  unusual fold
275. Outer capsid protein sigma 3 [64464] (1)
  unusual fold
276. NinB [103369] (1)
  unusual fold; intertwined dimer; consists of two different structural domains
277. SSo0622-like (Pfam 02676) [111277] (1)
  alpha(2)-beta(2)-alpha-beta-alpha-beta(2)-alpha; 2 layers: a/b; antiparallel beta-sheet: order 21354; strands 1,3 and 5 and the C-terminal helix are longer than other secondary structures
278. Putative modulator of DNA gyrase, PmbA/TldD (Pfam 01523) [111282] (1)
  consists of two different alpha+beta domains; d1: [duplication of alpha-beta(3)-alpha motif; 2 layers: a/b; antiparallel beta-sheet, order: 321456; strands 1, 2, 4 and 5 are twice longer than other secondary structures]; d2 [ complex fold; contains beta-barrel (n=5, S=10)]
279. Non-globular alpha+beta subunits of globular proteins [56567] (1)
  not a true fold
Multi-domain proteins (alpha and beta) [56572] (46)
Folds consisting of two or more domains belonging to different classes
1. Serpins [56573] (1)
  contains a cluster of helices and a beta-sandwich
2. Replication terminator protein (Tus) [56595] (1)
  contains a cluster of helices and a beta-sandwich
3. beta-lactamase/transpeptidase-like [56600] (1)
  contains a cluster of helices and an alpha+beta sandwich
4. 2-methylcitrate dehydratase PrpD [103377] (1)
  consists of an all-alpha and alpha+beta domains
5. Antivirulence factor [103382] (1)
  contains a helical bundle with a buried helix and an alpha+beta insert domain
6. Virulence-associated V antigen [103387] (1)
  consists of an all-alpha and alpha+beta domains connected by antiparallel coiled coil
7. ADP ribosyl cyclase-like [56628] (1)
  contains a cluster of helices and an alpha/beta domain
8. Heme-dependent catalases [56633] (1)
  contains an (8,10) beta-barrel and an all-alpha domain
9. Acyl-CoA dehydrogenase NM domain-like [56644] (1)
  2 domains: (1) all-alpha: 5 helices; (2) contains an open beta-sheet barrel: n*=5, S*=8; complex topology
10. Carbohydrate phosphatase [56654] (1)
  N-terminal domain is an alpha+beta, C-terminal domain is an alpha/beta with mixed beta-sheet
11. DNA/RNA polymerases [56671] (1)
  divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members
12. beta and beta-prime subunits of DNA dependent RNA-polymerase [64483] (1)
  Multidomain subunits of complex domain organization
13. Adenylylcyclase toxin (the edema factor) [81299] (1)
  3 domains: (1&2) alpha+beta, with domain 2 being inserted in domain 1; (3) all-alpha
14. Prokaryotic type I DNA topoisomerase [56711] (1)
  4 domains: (1) Toprim alpha/beta; (2&4) "winged helix"-like; (3) barrel: n=6, S=8
15. Type II DNA topoisomerase [56718] (1)
  4 domains: (1) toprim alpha/beta; (2) "winged helix"-like; (3) alpha+beta; (4) all-alpha
16. DNA topoisomerase IV, alpha subunit [56725] (1)
  2 domains: (1) toprim alpha/beta; (2) "winged helix"-like
17. DNA primase core [56730] (1)
  2 domains: (1) alpha+beta; (2) toprim alpha/beta
18. Recombination protein RecR [111303] (1)
  consists of three domains: alpha-helical dimerisation domain (res. 1-53) with HhH motif (Pfam 00633); 'treble cleft' C4 zinc-finger domain (54-76; Pfam 02132); and Toprim domain (76-199; segment-swapped dimer; Pfam 01751)
19. Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment [56740] (1)
  2 domains: alpha+beta and all-beta
20. D-aminoacid aminotransferase-like PLP-dependent enzymes [56751] (1)
  2 domains: (1) alpha+beta: beta3-alpha2-beta2; (2) alpha/beta, a part of its mixed sheet forms barrel: n=6, S=8
21. Nickel-iron hydrogenase, large subunit [56761] (1)
  3 domains: (1) all-alpha; (2&3) alpha+beta
22. Nickel-iron hydrogenase, small subunit [56769] (1)
  2 domains: (1) alpa/beta; (2) Fe-S cluster-bound
23. Dehydroquinate synthase-like [56795] (1)
  2 domains: (1) alpha/beta of a Rossmann-fold topology, binds NAD (2) multihelical array
24. Siroheme synthase middle domains-like [75614] (1)
  2 domains: (1) alpha+beta, 2 layers; (2) 3/4-helical bundle, right-handed twist, left-handed superhelix
25. Acetyl-CoA synthetase-like [56800] (1)
  4 domains: (1&2) duplication: share the same alpha/beta fold; (3) beta-barrel; (4) alpha+beta
26. Ribosomal protein L1 [56807] (1)
  2 domains: (1) alpha+beta; (2) alpha/beta (interrupts domain 1)
27. Release factor (Pfam 00472) [75619] (1)
  4 domains: (1) 3-helical bundle; (2) alpha+beta of ferredoxin-like fold (3 and 4) alpha+beta of dsRDB-like fold
28. YebC-like [75624] (1)
  3 domains: (1) 3-helical bundle; (2 and 3 ) alpha+beta of different folds: domain 3 has a ferredoxin-like fold and is inserted in domain 2
29. Cullin homology domain [75631] (1)
  3 domains: (1) 4-helical bundle; (2) alpha+beta; (3) "winged helix"-like
30. Sec1/munc18-like (SM) proteins [56814] (1)
  3 domains: (1 and 2) alpha+beta; (3) mostly alpha, inserted in domain 2
31. Prismane protein-like [56820] (1)
  3 domains: (1) spectrin repeat-like 3-helical bundle; (2 and 3) alpha/beta: Rossmann-fold topology
32. Subunits of heterodimeric actin filament capping protein Capz [90095] (1)
  3 domains: (1) protozoan pheromone-like alpha-helical bundle; (2) rubredoxin-like domain lacking metal-binding site; (3) alpha+beta heterodimerisation domain: alpha-beta(5)-alpha
33. Upper collar protein gp10 (connector protein) [56825] (1)
  2 domains: (1) alpha-helical bundle; (2) beta-barrel (n=5, S=8)
34. Phase 1 flagellin [64517] (1)
  3 domains: (1) alpha-helical bundle; (2&3) complex all-beta folds
35. 39 kda initiator binding protein, IBP39, C-terminal domains [103408] (1)
  2 closely associated domains: (1) all-alpha, EF-hand like; (2) alpha+beta, Frataxin-like
36. Hypothetical protein At2g17340 [111320] (1)
  2 domains; d1: [all-alpha; 3-helical bundle, similar to the immunoglobulin/albumin-binding domain-like fold (scop_cf 46996)]; d2: [alpha/beta; 3 layers, a/b/a; 6-stranded mixed beta-sheet, order: 321456, strand 6 is antiparallel to the rest]
37. Urocanase (Pfam 01175) [111325] (1)
  3 domains; d1: alpha+beta [alpha(2)-beta(3); mixed sheet: 213]; d2: alpha/beta of the NAD(P)-binding Rossmann-fold superfamily (scop_sf 51735, most similar to scop_fa 51883 and scop_fa 51736); d3: alpha+beta of the glutamine synthetase/guanido kinase fold (scop_cf 55930); d1 and d3 form a single beta-sheet
38. NAD kinase (Pfam 01513) [111330] (1)
  2 domains: d1 [alpha/beta; related to the PFK N-terminal domain (scop_sf 53784)]; d2 [all-beta; atypical beta-sandwich made of 4 structural repeats of beta(3) unit]
39. QueA-like (Pfam 02547) [111336] (1)
  2 domains; d1 (1-64,174-335) [alpha/beta; 3 layers, a/b/a; mixed beta sheet of 9 strands, order: 219863457; strands 1, 5 and 8 are antiparallel to the rest]; d2 (65-142) [all-beta; barrel, closed (n=6, S=10); greek-key; topologically similar to the split barrel fold (scop_cf 50474)
40. CbiD-like (Pfam 01888) [111341] (1)
  2 domains; (1) alpha+beta (res 1-192), a circularly permuted rS5 domain 2-like fold (scop_cf 54210); (2) alpha/beta with parallel beta-sheet of 4 strands, order 2134
41. Rap/Ran-GAP (Pfam 02145) [111346] (1)
  consists of two domains; d1: alpha+beta (78-190; alpha-beta(4)-alpha-beta-alpha; 3 layers; antiparallel beta-sheet of 5 strands; order 51234); d2: alpha/beta similar to the G-domain fold (191-381; scop_fa 52592)
42. NSP3 homodimer [69902] (1)
  2 domains: (1) all-alpha, (2) alpha+beta; asymmetric homodimer with each domain intertwining with its counterpart
43. Membrane penetration protein mu1 [69907] (1)
  4 domains: three intertwined predominately alpha domains and one jelly-roll beta-sandwich
44. Reovirus inner layer core protein p3 [56830] (1)
  large protein without apparent domain division; has a number of all-alpha regions and one all beta domain near the C-end
45. L-A virus major coat protein [82855] (1)
  large protein without apparent domain division
46. Major capsid protein VP5 [103416] (1)
  large protein without apparent domain division
Membrane and cell surface proteins and peptides [56835] (47)
Does not include proteins in the immune system
1. Toxins' membrane translocation domains [56836] (5)
  multi-helical domains of various folds which is thought to unfold in the membrane
2. Family A G protein-coupled receptor-like [81322] (1)
  core: up-and-down bundle of seven transmembrane helices tilted 20 degrees with respect to the plane of the membrane
3. Single transmembrane helix [81407] (30)
  not a true fold
4. Bacterial photosystem II reaction centre, L and M subunits [81484] (1)
  five transmembrane helices forming a sheet-like structure
5. Cytochrome c oxidase subunit I-like [81443] (1)
  12 transmembrane helices in an approximate threefold rotational symmetric arrangement
6. Cytochrome c oxidase subunit III-like [81453] (1)
  core: 7 transmembrane helices organized into two bundles, one formed by the first two helices and the other by the rest
7. Transmembrane helix hairpin [81334] (2)
  two antiparallel transmembrane helices
8. F1F0 ATP synthase subunit A [81337] (1)
  core: up-and-down bundle of four transmembrane helices
9. Aquaporin-like [81339] (1)
  core: 8 helices, 2 short helices are surrounded by 6 long transmembrane helices
10. Ammonium ransporter (Pfam 00909) [111351] (1)
  11 transmembrane helices; duplication: consist of 2 structural repeats of five helices each plus extra C-terminal helix
11. MFS general substrate transporter [103472] (1)
  12 transmembrane helices; duplication: the N- and C-terminal halves are structurally similar
12. Clc chloride channel [81341] (1)
  core: 18 transmembrane helices
13. Voltage-gated potassium channels [81325] (1)
  oligomeric transmembrane alpha-helical proteins
14. Small-conductance potassium channel [81328] (1)
  oligomeric transmembrane alpha-helical protein
15. Gated mechanosensitive channel [81331] (1)
  oligomeric transmembrane alpha-helical protein
16. Neurotransmitter-gated ion-channel transmembrane pore [90111] (1)
  heteropentameric transmembrane alpha-helical protein; 4 transmembrane helices per subunit
17. Mechanosensitive channel protein MscS (YggB), transmembrane region [82860] (1)
  oligomeric fold; 3 transmembrane helices per subunit
18. Multidrug resistance efflux transporter EmrE [103480] (1)
  oligomeric fold; 3 transmembrane helices per subunit
19. V-type ATP synthase subunit C [103485] (1)
  9 transmembrane helices
20. Preprotein translocase SecY subunit [103490] (1)
  10 transmembrane helices forming of a gated channel
21. Photosystem I subunits PsaA/PsaB [81559] (1)
  core:11 transmembrane helices
22. Photosystem I reaction center subunit X, PsaK [81564] (1)
  core: hairpin of two transmembrane helices
23. Photosystem I reaction center subunit XI, PsaL [81569] (1)
  core: three transmembrane helices, bundle
24. ABC transporter involved in vitamin B12 uptake, BtuC [81346] (1)
  multihelical; complex architecture with several transmembrane helices
25. Multidrug resistance ABC transporter MsbA, N-terminal domain [90122] (1)
  multihelical; complex architecture with several transmembrane helices
26. Multidrug efflux transporter AcrB transmembrane domain [82865] (1)
  12 transmembrane helices; duplication: the N- and C-terminal halves of the whole proteins are structurally similar
27. a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) [81649] (1)
  core: three transmembrane helices, up-and-down bundle
28. Heme-binding four-helical bundle [81344] (3)
  core: four transmembrane helices, up-and-down bundle, binds one or two heme groups in between the helices
29. 14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) [81525] (1)
  membrane-associated alpha-helical protein; no transmembrane helices
30. Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) [81532] (1)
  membrane-associated alpha-helical protein; no transmembrane helices
31. Mitochondrial ATP synthase coupling factor 6 (Pfam 05511) [111356] (1)
  2 helices, hairpin
32. Calcium ATPase, transmembrane domain M [81666] (1)
  core: multihelical; consists of three transmembrane regions of 2, 2 and 6 helices, separated by cytoplasmic domains
33. Light-harvesting complex subunits [56917] (1)
  membrane all-alpha fold
34. Mitochondrial carrier [103505] (1)
  membrane all-alpha fold; 6-helical "barrel" with internal binding cavity
35. Chlorophyll a-b binding protein [103510] (1)
  membrane all-alpha fold; three transmembrane helices
36. Transmembrane beta-barrels [56924] (6)
  not a true fold, gathers together transmembrane barrels of different (n,S)
37. Integral outer membrane protein TolC, efflux pump component [56953] (1)
  subunit fold contains tandem repeat of alpha-beta hairpin-alpha(2) motif
  trimeric fold contains barrel (n=12, S=18) formed by beta-hairpins, two from each subunit, and a bundle of helices with a channel running through it
38. HlyD-like secretion proteins (Pfam 00529) [111368] (1)
  consists of three domains: beta-barrel (res. 29-38,170-259; scop_cf 50412); barrel-sandwich hybrid (39-72,135-169; scop_sf 51230) and long alpha-hairpin (73-134; scop_cf 46556)
39. Leukocidin-like [56958] (1)
  subunit fold contains beta-sandwich of Ig-like (grerk-key) topology and a beta-ribbon arm that forms an oligomeric transmembrane barrel
40. Lipovitellin-phosvitin complex; beta-sheet shell regions [56967] (1)
  contains several large open beta-sheets
41. Aerolisin/ETX pore-forming domain [56972] (1)
  3 domains: (1) alpha+beta; (2&3) all-beta
42. Perfringolysin [56977] (1)
  2 domains: (1) alpha+beta; (2) all-beta, similar to the CalB domain fold but the two last strands are transposed
43. Viral glycoprotein, central and dimerisation domains [56982] (1)
  2 intertwined domains; all-beta and alpha+beta
44. VP4 membrane interaction domain [111378] (1)
  2 domains; d1: complexed all-beta fold; d2: coiled-coil (trimeric) helical region
45. Head and neck region of the ectodomain of NDV fusion glycoprotein [69921] (1)
  3 intertwined all-beta domains
46. OmpH-like (Pfam 03938) [111383] (1)
  trimer; one subunit consists of an alpha/beta oligomerization subdomain [3-stranded parallel beta-sheet, order 213], and an antiparallel coiled coil
47. Anthrax protective antigen [56987] (1)
  4 domains; I (res. 14-225) and II (226-487) are beta-sandwiches of similar gamma-crystallin like topologies; III (488-594) has a beta-grasp like fold; IV (595-735) has an Ig-like fold
Small proteins [56992] (75)
Usually dominated by metal ligand, heme, and/or disulfide bridges
1. Insulin-like [56993] (1)
  nearly all-alpha
  can be classified as disulfide-rich
2. Toxic hairpin [57006] (3)
  disulfide crosslinked alpha-helical hairpin
3. Knottins (small inhibitors, toxins, lectins) [57015] (19)
  disulfide-bound fold; contains beta-hairpin with two adjacent disulfides
4. PMP inhibitors [57282] (1)
  disulfide-rich fold; all-beta: 3 antiparallel strands
5. Midkine [57287] (1)
  disulfide-rich fold; all-beta: 3 antiparallel strands
6. TSP-1 type 1 repeat [82894] (1)
  disulfide-rich fold; all-beta: 3 antiparallel strands
7. Amb V allergen [57295] (1)
  disulfide-rich; alpha+beta: 3 antiparallel strands followed by a short alpha helix
8. Snake toxin-like [57301] (1)
  disulfide-rich fold: nearly all-beta
9. BPTI-like [57361] (1)
  disulfide-rich alpha+beta fold
10. Defensin-like [57391] (1)
  Disulfide-rich fold, nearly all-beta
11. Hairpin loop containing domain-like [57413] (1)
  alpha+beta fold with two crossing loops
12. Neurotoxin III (ATX III) [57418] (1)
  disulfide-rich fold
13. LDL receptor-like module [57423] (1)
  disulfide-rich calcium-binding fold
14. Crambin-like [57428] (1)
  disulfide-rich alpha+beta fold
15. Kringle-like [57439] (1)
  disulfide-rich fold; nearly all-beta
16. Kazal-type serine protease inhibitors [100894] (1)
17. Plant proteinase inhibitors [100896] (1)
  disulfide-rich small alpha+beta fold; topological similarity to the Ovomucoid domain III
18. Trefoil/Plexin domain-like [57491] (2)
  disulfide-rich fold; common core is alpha+beta with two conserved disulfides
19. Necrosis inducing protein 1, NIP1 [103579] (1)
  disulfide-rich fold; all-beta; duplication: contains two structural repeats
20. Cystine-knot cytokines [57500] (1)
  disulfide-rich fold; common core is all-beta
21. Complement control module/SCR domain [57534] (1)
  disulfide-rich all-beta fold
22. Sea anemone toxin k [57545] (1)
  disulfide-rich all-alpha fold
23. Blood coagulation inhibitor (disintegrin) [57551] (1)
  small disulfide-rich
24. Methylamine dehydrogenase, L chain [57560] (1)
  disulfide-rich; nearly all-beta
25. Serine proterase inhibitors [57566] (1)
  disulfide-rich; nearly all-beta
26. TB module/8-cys domain [57580] (1)
  disulfide-rich; alpha+beta
27. TNF receptor-like [57585] (1)
  duplication: consists of three similar disulfide-rich domains
28. Heparin-binding domain from vascular endothelial growth factor [57592] (1)
  duplication: consists of two similar disulfide-rich domains, alpha+beta
29. Antifungal protein (AGAFP) [57597] (1)
  disulfide-rich; all-beta: open barrel, 5 strands; OB-fold-like
30. Fibronectin type I module [57602] (1)
  disulfide-rich, all-beta
31. Thyroglobulin type-1 domain [57609] (1)
  disulfide-rich, alpha+beta
32. Type X cellulose binding domain, CBDX [57614] (1)
  disulfide-rich, alpha+beta
33. Cellulose docking domain, dockering [64570] (1)
  disulfide-rich, alpha+beta
34. Carboxypeptidase inhibitor [57619] (1)
  disulfide-rich, alpha+beta
35. Invertebrate chitin-binding proteins [57624] (1)
  disulfide-rich
36. Pheromone ER-23 [69963] (1)
  disulfide-rich, all-alpha
37. Mollusk pheromone [90182] (1)
  disulfide-rich; all-alpha
38. Apical membrane antigen 1 [82909] (1)
  disulfide-rich, alpha+beta
39. Somatomedin B domain [90187] (1)
  disulfide-rich
40. Notch domain [90192] (1)
  disulfide-rich; all-alpha; calcium-binding
41. Mini-collagen I, C-terminal domain [103588] (1)
  disulfide-rich
42. Hormone receptor domain (HRM, Pfam 02793) [111417] (1)
  disulfide-rich all-beta fold; contains beta sandwich of 5 strands
43. Resistin (Pfam 06954) [111422] (1)
  disulfide-rich six-stranded beta-sandwich; jelly-roll
44. YAP1 redox domain [111429] (1)
  bipartite cysteine-rich all-alpha domain; a single helix in the N-terminal part (chain A) is linked by disulfides to the C-terminal part (chain B) [3-helical bundle of the RuvA C-terminal domain-like fold (scop_cf 46928)
45. GLA-domain [57629] (1)
  Calcium ion-bound
46. Cholecystokinin A receptor, N-domain [57641] (1)
  a few helical turns and a disulfide-crosslinked loop
47. HIV-1 VPU cytoplasmic domain [57646] (1)
  a few helical turns assembled without a hydrophobic core?
48. HIPIP (high potential iron protein) [57651] (1)
  folds around 4Fe-4S cluster
49. Ferredoxin thioredoxin reductase (FTR), catalytic beta chain [57661] (1)
  folds around 4Fe-4S cluster
50. C2H2 and C2HC zinc fingers [57666] (1)
  alpha+beta metal(zinc)-bound fold: beta-hairpin + alpha-helix
51. Zn2/Cys6 DNA-binding domain [57700] (1)
  all-alpha dimetal(zinc)-bound fold
52. Glucocorticoid receptor-like (DNA-binding domain) [57715] (1)
  alpha+beta metal(zinc)-bound fold
53. SBT domain [103611] (1)
  consist of two different zn-binding subdomains, each subdomain resembles a distorted glucocorticoid receptor-like fold
54. Retrovirus zinc finger-like domains [57755] (1)
  metal(zinc)-bound fold
55. Rubredoxin-like [57769] (13)
  metal(zinc or iron)-bound fold; sequence contains two CX(n)C motifs, in most cases n = 2
56. Ribosomal protein L36 [57839] (1)
  zinc-bound beta-ribbon motif
57. Zinc-binding domain of translation initiation factor 2 beta [75688] (1)
  zinc-bound beta-ribbon motif
58. B-box zinc-binding domain [57844] (1)
  zinc-bound alpha+beta motif
59. RING/U-box [57849] (1)
  dimetal(zinc)-bound alpha+beta motif; structurally diverse
60. Pyk2-associated protein beta ARF-GAP domain [57862] (1)
  zinc-bound alpha+beta motif
61. Metallothionein [57867] (1)
  metal(iron)-bound fold
  duplication: consists of clear structural/sequence repeats
62. Zinc domain conserved in yeast copper-regulated transcription factors [57878] (1)
  metal(zinc)-bound alpha+beta fold
63. Ada DNA repair protein, N-terminal domain (N-Ada 10) [57883] (1)
  metal(zinc)-bound alpha+beta fold
64. Cysteine-rich domain [57888] (1)
  dimetal(zinc)-bound alpha+beta fold
65. FYVE/PHD zinc finger [57902] (1)
  dimetal(zinc)-bound alpha+beta fold
66. Zn-binding domains of ADDBP [57916] (1)
  metal(zinc)-bound alpha+beta fold
67. Inhibitor of apoptosis (IAP) repeat [57923] (1)
  metal(zinc)-bound alpha+beta fold
68. CCCH zinc finger [90228] (1)
  metal(zinc)-bound alpha+beta fold
69. Zinc finger domain of DNA polymerase-alpha [90233] (1)
  Zn-binding, all-alpha fold
70. TAZ domain [57932] (1)
  all-alpha fold; Zn-binding sites are in the loops connecting helices
71. Cysteine-rich DNA binding domain, (DM domain) [82926] (1)
  alpha-helical fold with two Zn-binding sites
72. DnaJ/Hsp40 cysteine-rich domain [57937] (1)
  metal(zinc)-bound extended beta-hairpin fold
73. CCHHC domain [103636] (1)
  metal(zinc)-bound fold
74. Sec-C motif [103641] (1)
  metal(zinc)-bound fold
75. TSP type-3 repeat [103646] (1)
  metal(calcium)-bound fold
Coiled coil proteins [57942] (6)
Not a true class
1. Parallel coiled-coil [57943] (28)
  this is not a true fold; includes oligomers of shorter identical helices
2. Tetramerization domain of the Mnt repressor [58058] (1)
3. Stalk segment of viral fusion proteins [58063] (3)
  core: trimeric coiled coil
4. Antiparallel coiled-coil [58086] (16)
  this is not a true fold; contains at least two very long antiparallel helices
5. Apolipoprotein A-I [58112] (1)
  tetrameric antiparallel coiled coil, closed in a circuit
6. Apolipoprotein A-II [82935] (1)
  segmented tetrameric parallel coiled coil
Low resolution protein structures [58117] (24)
Not a true class
1. Ribosome and ribosomal fragments [58118] (1)
2. Helicase [58135] (1)
3. ATP synthase [58140] (1)
4. Membrane ion ATPase [82940] (1)
5. Multidrug resistance ABC transporter [64606] (1)
6. Electron transport chains [58146] (1)
7. Photosystems [58155] (1)
8. Viruses and virus-receptor complexes [58162] (1)
9. Reovirus components [58175] (1)
10. Virus envelope proteins [75718] (1)
11. Bacteriophage HK97 procapsid (prohead II) [64611] (1)
12. Bacteriophage T4 3D cryo-EM reconstruction [103674] (1)
13. RNA polymerase [58180] (1)
14. Blood clotting [58187] (1)
15. Microtubule complexes [58193] (1)
16. Muscle protein complexes [64616] (1)
17. Ep-cadherin [103681] (1)
18. Transferrin receptor-transferrin complex [103686] (1)
19. Signal recognition particle (SRP) complex [103691] (1)
20. GroE chaperon [69998] (1)
21. AP1 clathrin adaptor core [111484] (1)
22. anthrax toxin protective antigen-receptor complex [111489] (1)
23. Computational models partly based on NMR data [58198] (1)
24. Proteins of incorrect, partial and unknown sequence [58207] (1)
Peptides [58231] (116)
Peptides and fragments. Not a true class
1. Membrane ion channel-forming peptide antibiotics containing D-aminoacids [58232] (1)
2. Lantibiotic peptides [58243] (1)
  peptide antibiotic
3. Leucocin-like bacteriocin [100898] (1)
  consists of a conserved, disulfide-containing N-terminal region (forming a beta-sheet) and a C-terminal helix
4. Antimicrobial beta-hairpin [58251] (1)
  contains beta-hairpin crosslinked by disulfide bridge(s)
5. Antimicrobial helix [58268] (1)
  antibiotic peptide
6. Macrocyclic bacteriocins [58278] (1)
  macrocyclic antimicrobial peptide; bacteriocin
7. Peptide hormones [58283] (1)
  contains one alpha-helix
8. Angiotensin [90269] (1)
9. delta toxin-like [58307] (2)
  single alpha helix
10. PSP1-like [58312] (1)
11. Arg-rich RNA binding peptides [58321] (6)
12. DNA-binding domains of HMG-I(Y) [58348] (1)
13. VPR protein fragments [58353] (1)
14. Inactivation gate of potassium and sodium channels [58358] (1)
15. Coagulation factor VIII, membrane-binding peptide [58368] (1)
16. Phosphocholine cytidylyltransferase membrane-binding peptides [58373] (1)
17. Parathyroid hormone fragments (residues between 1 and 39) [58378] (1)
18. Corticotropin releasing hormone [58384] (1)
19. Liposaccharide-binding protein CAP18 (residues 106-137) [58389] (1)
20. Polymorphic antigen SPAM-H1 (residues 90-127) [58394] (1)
21. Insect toxins [58399] (1)
22. Tertiapin [58404] (1)
  small disulfide-rich peptide
23. Antifreeze polypeptide HPLC-6 [58409] (1)
24. Troponin I fragments [58414] (1)
25. Pilin fragments [58420] (1)
26. RP71935 [58427] (1)
27. Atrial natriuretic peptide [58432] (1)
28. Compstatin [58437] (1)
29. Membrane-bound antimicrobial peptides [58442] (1)
30. Endothelin-like [58449] (1)
  small disulfide-rich
31. Heat-stable enterotoxin (HSE) [58457] (1)
32. Conotoxins [58464] (1)
  disulfide-rich fold
33. Conantokin [58494] (1)
34. Contryphan-R [58502] (1)
35. Kappa-hefutoxin-like [58507] (2)
  hairpin of two short helices crosslinked with two disulfides
36. Penaeidin-3a [103726] (1)
37. Bradykinin [58512] (1)
38. Transmembrane helical fragments [58517] (1)
39. Topogenic peptides [58555] (4)
40. Phospholamban fragments [58568] (1)
41. Influenza hemagglutinin fragments [64631] (1)
42. Fragments of bowman-birk inhibitor [58574] (1)
43. Fragments of apolipoproteins [58579] (1)
44. Transactivation protein TAT [58593] (1)
45. Proline pipe [58599] (1)
46. Amyloid peptides [58604] (1)
47. Gelsolin fragment (residues 150-169) [58609] (1)
48. Acetylcholine receptor fragment (residues alpha 67-76) [58614] (1)
49. Thrombomodulin EGF domain fragment (residues 409-426) [58619] (1)
50. C-terminal fragment of thermolysin [63387] (1)
51. Capsid protein major homology region peptide analog [58629] (1)
52. CD4 and CD8 receptor regions [58635] (1)
53. Proto-oncogene tyrosine-protein kinase lck CD4/CD8 interacting region [103748] (1)
54. Heparin binding site of non collagenous domain I (nc1) of collagen facit xiv [58640] (1)
55. GroES fragments [58645] (1)
56. cAMP and cGMP phosphodiesterase (PDE) fragments [58650] (1)
57. HIV-1 Nef protein fragments [58657] (1)
58. HIV-1 envelope gp120 protein fragments [58662] (1)
59. HIV-1 gp41 fragments [70010] (1)
60. Hepatitis C virus N-terminal capsid protein fragment 2-45 [58667] (1)
61. P27(KIP1) fragment 22-106 [58672] (1)
62. Transducin alpha-1 subunit rhodopsin binding domain (res. 340-350) [58677] (1)
63. Transducin gamma-t1 subunit rhodopsin bound fragment (res. 60-71) [90290] (1)
64. alpha-lactalbumin peptide model [58682] (1)
65. Coat protein-binding domain of bacteriophage P22 scaffolding protein [58687] (1)
66. Immunoreceptor tyrosine kinase activation motif, ITAM [58692] (1)
67. Integrin fragments [58697] (1)
68. Human glutathione reductase (HGR) inhibitor [58702] (1)
69. Small subunit C-terminal inhibitory peptide of ribonucleotide reductase [58707] (1)
70. Histone H3 C-terminal fragment 130-135 [58712] (1)
71. Smad-binding domain of Sara [58717] (1)
72. Transactivation domain [81275] (1)
73. Nuclear receptor coactivator Src-1 [100901] (1)
74. TBP-binding domain of the transcription factor IIIb Brf1 subunit [90297] (1)
75. BRCA2 BRC4 repeat [82985] (1)
76. Peptide derived from p-21 activated kinase [58722] (1)
77. pak1 autoregulatory domain [58728] (1)
78. Translocated intimin receptor (tir) intimin-binding domain [58733] (1)
79. Fragments of the L-type calcium channel alpha subunit Cav.1 (dihydropyridine receptor) [58738] (1)
80. Tumor suppressor p53 fragments [58743] (1)
81. FxFG nucleoporin repeats [58748] (1)
82. beta-Catenine bound non-globular protein regions [58753] (1)
83. Synaptobrevin-II fragments [58758] (1)
84. VMIP-II fragment [58763] (1)
85. Papillomavirus e6-interacting peptide of e6ap [58768] (1)
86. Isolated insulin B-chain [58773] (1)
87. N-terminal hairpin of ubiquitin (residues 1-17) [58778] (1)
88. alpha-helical hairpin of p8mtcp1 [58783] (1)
89. Syndecan-4 cytoplasmic domain [64638] (1)
90. Actin-binding peptides [70017] (1)
91. Pituitary adenylate cyclase activating polypeptide, pacap21 [64643] (1)
92. Rack1 interaction site of the CAMP-specific phosphodiesterase pde4d5. [70022] (1)
93. Prepeptide of 5-ALAS [70027] (1)
94. Cholecystokinin receptor fragments [64648] (1)
95. the cytoplasmic N-terminus of the bk beta-subunit kcnmb2 [70032] (1)
96. Trypsin inhibitor SFTIf-1 [64653] (1)
97. Prion protein fragments [70037] (1)
98. Tumor suppressor protein p19-ARF fragment [70042] (1)
99. Antennapedia homeodomain fragments [70047] (1)
100. Sheep myeloid antimicrobial peptide SMAP29 based peptides [75751] (1)
101. alpha-2a adrenergic receptor pepride t3-i2 [75756] (1)
102. Catestatin fragment from chromogranin A [75761] (1)
103. Bhpbr3, the Baff-binding loop of br3 embedded in a beta-hairpin peptide [82992] (1)
104. N-terminal fragment of gastric H/K-ATPase [82997] (1)
105. Barstar fragment [83002] (1)
106. Cannabinoid receptor 1 (CB1) fragment [83007] (1)
107. Ribosomal protein L10 [64658] (1)
108. Ubiquitin interacting motif (UIM) [90302] (1)
109. Metal-binding peptide from MerP [103758] (1)
110. Marinostatin, MstI [103763] (1)
111. Cross-reactive peptides from 60S acidic ribosomal protein p2 [103768] (1)
112. NTR, cyclotide processing element [111516] (1)
113. HMG-box transcription factor 1 fragments [111523] (1)
114. MAD protein fragments [111528] (1)
115. Fragments of TNF receptors [111533] (1)
116. Ezrin-radixin-moesin binding phosphoprotein 50 (ebp50) fragments [111538] (1)
Designed proteins [58788] (42)
Experimental structures of proteins with essentially non-natural sequences. Not a true class
1. New fold designs [103774] (1)
2. In vitro evolution products [103779] (1)
3. Hybrid and chimeric proteins [58789] (1)
4. Amphiphilic (amphipathic) alpha helix [58798] (1)
5. Collagen-like peptides [58805] (1)
6. Coiled serine [58812] (1)
7. Designed trimeric coiled-coil [100903] (1)
8. Designed heterodimeric leucine zipper [58822] (1)
9. Thermostable heterotrimeric coiled coil [58827] (1)
10. Designed four-helix bundle protein [58832] (1)
11. Designed single chain three-helix bundle [58839] (1)
  not a true fold: both possible topologies are created
12. Peptide f (amphiphilic octadecapeptide) [58846] (1)
13. Retro-GCN4 leucine zipper [58851] (1)
14. Glytm1bzip [70053] (1)
15. Zinc finger design [58856] (1)
16. Protein A Ig(Fc)-binding domain mimics [58863] (1)
17. Zinc finger based beta-beta-alpha motif [58868] (1)
18. helix-turn-helix motif [58877] (1)
19. alpha2d [58882] (1)
20. RH4 designed right-handed coiled coil tetramer [58887] (1)
21. TPR domain-based design [90307] (1)
22. Erythropoietin (EPO) mimetic peptides [58892] (1)
23. IL-1 receptor type 1 antagonist peptide AF10847 [58897] (1)
24. Octreotide (Sandostatine), a somatostatine analogue [58902] (1)
25. Calmodulin [58907] (1)
26. Prototype WW domain [58912] (1)
27. Artificial ankyrin repeat proteins [83017] (1)
28. Carboxypeptidase A prodomain-based design [103789] (1)
29. Scorpion toxin-based designs [58917] (1)
30. TH (toxin hand)-motif beta-sheet mini-protein designs [64673] (1)
31. Inhibitor of mammalian ribonucleotide reductase [58925] (1)
32. Integrin-binding RGD peptide [64682] (1)
33. Peptide antagonists of IGF-1 [64687] (1)
34. beta-hairpin design [64692] (1)
35. Trp-cage miniprotein [75769] (1)
36. Synthetic high affinity IgE receptor antagonists [64703] (1)
37. IFN mimetic syr6 [75779] (1)
38. TAZ (CH) Zn-binding domain based design [75784] (1)
39. Beta-sheet designs [75789] (1)
40. PW2, a tryptophan-rich anticocidial peptide [75796] (1)
41. Designed EF-hand type cation-binding loop [111554] (1)
42. Metalloporphyrin-binding designed peptides [90314] (1)