Structural Classification of Proteins
home mail help root up expand collapse

Changes in domain definitions and classification
Release 1.65 ---> 1.67

Root: scop

Classes:

  1. All alpha proteins [46456] (11)
    1. DNA/RNA-binding 3-helical bundle [46688] (2)
      1. Homeodomain-like [46689] (1)
        1. Transcriptional regulator TyrR, C-terminal domain [63469] (1)
          1. Transcriptional regulator TyrR, C-terminal domain [63470]
            1. Haemophilus influenzae [63471] (1) picpic
      2. "Winged helix" DNA-binding domain [46785] (1)
        1. CAP C-terminal domain-like [46796] (1)
          1. Listeriolysin regulatory protein PrfA, C-terminal domain [88975]
            1. Bacteria (Listeria monocytogenes) [88976] (2) picpic
    2. Ferritin-like [47239] (1)
      1. Ferritin-like [47240] (1)
        1. Ribonucleotide reductase-like [47253] (1)
          1. Manganese catalase (T-catalase) [47263]
            1. Lactobacillus plantarum [74707] (12) picpic
    3. Bromodomain-like [47363] (1)
      1. RecG, N-terminal domain [69008] (1)
        1. RecG, N-terminal domain [69009] (1)
          1. RecG, N-terminal domain [69010]
            1. Thermotoga maritima [69011] (1) picpic
    4. SinR repressor dimerisation domain-like [47405] (1)
      1. SinR repressor dimerisation domain-like [47406] (1)
        1. SinR repressor dimerisation domain-like [47407] (1)
          1. Dimerization cofactor of HNF-1 alpha [47410]
            1. Mouse (Mus musculus) [47411] (16) picpic
    5. Met repressor-like [47597] (1)
      1. Met repressor-like [47598] (1)
        1. CopG/MetJ-like bacterial repressors [47604] (3)
          1. Transcriptional repressor CopG [47605]
            1. Streptococcus agalactiae [47606] (15) picpic
          2. Omega transcriptional repressor [69031]
            1. Streptococcus pyogenes [69032] (2) picpic
          3. Met repressor, MetJ (MetR) [47607]
            1. Escherichia coli [47608] (30) picpic
    6. Disulphide-bond formation facilitator (DSBA), insertion domain [47609] (1)
      1. Disulphide-bond formation facilitator (DSBA), insertion domain [47610] (1)
        1. Disulphide-bond formation facilitator (DSBA), insertion domain [47611] (2)
          1. Disulphide-bond formation facilitator (DSBA), insertion domain [47612]
            1. Escherichia coli [47613] (23) picpic
            2. Vibrio cholerae [47614] (1) picpic
    7. 6-phosphogluconate dehydrogenase C-terminal domain-like [48178] (1)
      1. 6-phosphogluconate dehydrogenase C-terminal domain-like [48179] (1)
        1. Mannitol 2-dehydrogenase [81843] (1)
          1. Mannitol 2-dehydrogenase [81844]
            1. Pseudomonas fluorescens [81845] (3) picpic
    8. FIS-like [48282] (1)
      1. FIS-like [48283] (1)
        1. FIS-like [48284] (2)
          1. FIS protein [48285]
            1. Escherichia coli [48286] (26) picpic
          2. DNA-binding domain of NTRC [48287]
            1. Salmonella typhimurium [48288] (2) picpic
    9. alpha-alpha superhelix [48370] (2)
      1. ARM repeat [48371] (3)
        1. HEAT repeat [48385] (2)
          1. Eukaryotic initiation factor eIF4G [48388]
            1. Human (Homo sapiens) [48389] (1) picpic
          2. CBP80, 80KDa nuclear cap-binding protein [63606]
            1. Human (Homo sapiens) [63607] (27) picpic
        2. IP3 receptor type 1 binding core, domain 2 [81895] (1)
          1. IP3 receptor type 1 binding core, domain 2 [81896]
            1. Mouse (Mus musculus) [81897] (1) picpic
        3. Chemosensory protein Csp2 [81898] (1)
          1. Chemosensory protein Csp2 [81899]
            1. Cabbage moth (Mamestra brassicae) [81900] (7) picpic
      2. Phosphoinositide-binding clathrin adaptor, N-terminal domain [48473] (1)
        1. Phosphoinositide-binding clathrin adaptor, N-terminal domain [48474] (2)
          1. Clathrin assembly lymphoid myeloid leukaemia protein, Calm [48475]
            1. Rat (Rattus norvegicus) [48476] (4) picpic
          2. AP180 (Lap) [48477]
            1. Fruit fly (Drosophila melanogaster) [48478] (2) picpic
    10. GroEL equatorial domain-like [48591] (1)
      1. GroEL equatorial domain-like [48592] (1)
        1. Group II chaperonin (CCT, TRIC), ATPase domain [48596] (1)
          1. Thermosome, E domain [48597]
            1. Archaeon Thermoplasma acidophilum [48598] (4) picpic
    11. Non-globular all-alpha subunits of globular proteins [48661] (1)
      1. Nuclear receptor coactivator Src-1 [48682] (1)
        1. Nuclear receptor coactivator Src-1 [48683] (1)
          1. Nuclear receptor coactivator Src-1 [48684]
            1. Human (Homo sapiens) [48685] (1) picpic
  2. All beta proteins [48724] (5)
    1. Viral protein domain [49817] (1)
      1. Viral protein domain [49818] (1)
        1. Top domain of virus capsid protein [49819] (1)
          1. Virus capsid protein vp7 (BTV-10 vp7), central (top) domain [49820]
            1. African horse sickness virus [49822] (3) picpic
    2. Concanavalin A-like lectins/glucanases [49898] (1)
      1. Concanavalin A-like lectins/glucanases [49899] (1)
        1. Galectin (animal S-lectin) [49932] (4)
          1. S-lectin, different isoforms [49933]
            1. Cow (Bos taurus) [49934] (12) picpic
            2. Human (Homo sapiens) [49935] (12) picpic
            3. Chicken (Gallus gallus) [49936] (2) picpic
            4. Toad (Bufo arenarum) [49937] (4) picpic
    3. OB-fold [50198] (1)
      1. Bacterial enterotoxins [50203] (1)
        1. Superantigen toxins, N-terminal domain [50219] (1)
          1. Staphylococcal enterotoxin B, SEB [50226]
            1. Staphylococcus aureus [50227] (1) picpic
    4. beta-Roll [51119] (1)
      1. Serralysin-like metalloprotease, C-terminal domain [51120] (1)
        1. Serralysin-like metalloprotease, C-terminal domain [51121] (4)
          1. Metalloprotease [51122]
            1. Pseudomonas aeruginosa [51123] (3) picpic
            2. Serratia marcescens [51124] (4) picpic
            3. Erwinia chrysanthemi [82189] (5) picpic
            4. Pseudomonas sp., tac ii 18 [82190] (8) picpic
    5. Double-stranded beta-helix [51181] (1)
      1. cAMP-binding domain-like [51206] (1)
        1. Listeriolysin regulatory protein PrfA, N-terminal domain [89419] (1)
          1. Listeriolysin regulatory protein PrfA, N-terminal domain [89420]
            1. Bacteria (Listeria monocytogenes) [89421] (2) picpic
  3. Alpha and beta proteins (a/b) [51349] (12)
    Mainly parallel beta sheets (beta-alpha-beta units)
    1. NAD(P)-binding Rossmann-fold domains [51734] (1)
      1. NAD(P)-binding Rossmann-fold domains [51735] (1)
        1. 6-phosphogluconate dehydrogenase-like, N-terminal domain [51868] (1)
          1. Mannitol 2-dehydrogenase [82301]
            1. Pseudomonas fluorescens [82302] (3) picpic
    2. The "swivelling" beta/beta/alpha domain [52008] (1)
      1. GroEL apical domain-like [52029] (1)
        1. Group II chaperonin (CCT, TRIC), apical domain [52034] (1)
          1. Thermosome, A-domain [52035]
            1. Archaeon Thermoplasma acidophilum [52036] (7) picpic
    3. Outer arm dynein light chain 1 [52074] (1)
      1. Outer arm dynein light chain 1 [52075] (1)
        1. Outer arm dynein light chain 1 [52076] (1)
          1. Outer arm dynein light chain 1 [52077]
            1. Green algae (Chlamydomonas reinhardtii) [52078] (2) picpic
    4. Flavodoxin-like [52171] (2)
      1. Cutinase-like [52259] (1)
        1. Cutinase-like [52260] (3)
          1. Cutinase [52261]
            1. Fungus (Fusarium solani), subsp. pisi [52262] (44) picpic
          2. Acetylxylan esterase [52263]
            1. Penicillium purpurogenum [52264] (3) picpic
            2. Trichoderma reesei [52265] (2) picpic
      2. Class I glutamine amidotransferase-like [52317] (2)
        1. Putative sigma cross-reacting protein 27A (SCRP-27A, EllB) [89605] (1)
          1. Putative sigma cross-reacting protein 27A (SCRP-27A, EllB) [89606]
            1. Escherichia coli [89607] (4) picpic
        2. HSP31 chaperone [89608] (1)
          1. HSP31 (HchA; YedU) [89609]
            1. Escherichia coli [89610] (1) picpic
    5. Cysteine hydrolase [52498] (1)
      1. Cysteine hydrolase [52499] (2)
        1. N-carbamoylsarcosine amidohydrolase [52500] (1)
          1. N-carbamoylsarcosine amidohydrolase [52501]
            1. Arthrobacter sp. [52502] (4) picpic
        2. Pyrazinamidase/nicotinamidase-like [52503] (3)
          1. Pyrazinamidase/nicotinamidase [69465]
            1. Archaeon Pyrococcus horikoshii [69466] (2) picpic
          2. Phenazine biosynthesis protein PhzD [89643]
            1. Pseudomonas aeruginosa [89644] (2) picpic
          3. YcaC [52504]
            1. Escherichia coli [52505] (2) picpic
    6. Phosphosugar isomerase [52511] (1)
      1. Phosphosugar isomerase [52512] (2)
        1. Glucosamine 6-phosphate deaminase/isomerase [52513] (1)
          1. Glucosamine 6-phosphate deaminase/isomerase [52514]
            1. Escherichia coli [52515] (16) picpic
        2. D-ribose-5-phosphate isomerase (RpiA), catalytic domain [75176] (3)
          1. D-ribose-5-phosphate isomerase (RpiA), catalytic domain [75177]
            1. Escherichia coli [75178] (6) picpic
            2. Haemophilus influenzae [82391] (2) picpic
            3. Archaeon Pyrococcus horikoshii [75179] (8) picpic
    7. Thiamin diphosphate-binding fold (THDP-binding) [52517] (1)
      1. Thiamin diphosphate-binding fold (THDP-binding) [52518] (1)
        1. Branched-chain alpha-keto acid dehydrogenase Pyr module [88741] (1)
          1. E1-beta subunit of pyruvate dehydrogenase (PP module) [89651]
            1. Human (Homo sapiens) [89652] (2) picpic
    8. (Phosphotyrosine protein) phosphatases II [52798] (1)
      1. (Phosphotyrosine protein) phosphatases II [52799] (1)
        1. Higher-molecular-weight phosphotyrosine protein phosphatases [52805] (1)
          1. Tyrosine phosphatase [52806]
            1. Yersinia enterocolitica [52812] (6) picpic
    9. Thioredoxin fold [52832] (1)
      1. Thioredoxin-like [52833] (2)
        1. Thioltransferase [52834] (1)
          1. Thioredoxin [52835]
            1. Escherichia coli [52836] (1) picpic
        2. Disulphide-bond formation facilitator (DSBA) [52858] (2)
          1. Disulphide-bond formation facilitator (DSBA) [52859]
            1. Escherichia coli [52860] (23) picpic
            2. Vibrio cholerae [52861] (1) picpic
    10. Phosphoglycerate mutase-like [53253] (1)
      1. Phosphoglycerate mutase-like [53254] (1)
        1. Phytase (myo-inositol-hexakisphosphate-3-phosphohydrolase) [53262] (3)
          1. Phytase (myo-inositol-hexakisphosphate-3-phosphohydrolase) [53263]
            1. Aspergillus ficuum [53264] (1) picpic
            2. Aspergillus niger [53265] (2) picpic
            3. Escherichia coli [53266] (7) picpic
    11. CoA transferase [53315] (1)
      1. CoA transferase [53316] (2)
        1. alpha subunit-like [74656] (3)
          1. Glutaconate:CoA transferase alpha [53318]
            1. Acidaminococcus fermentans [53319] (2) picpic
          2. Acetate:CoA transferase alpha [75257]
            1. Escherichia coli [75258] (2) picpic
          3. Succinate:CoA transferase, N-terminal domain [82464]
            1. Pig (Sus scrofa) [82465] (8) picpic
        2. beta subunit-like [74657] (2)
          1. Glutaconate:CoA transferase beta [53320]
            1. Acidaminococcus fermentans [53321] (2) picpic
          2. Succinate:CoA transferase, C-terminal domain [82466]
            1. Pig (Sus scrofa) [82467] (8) picpic
    12. Nucleotide-diphospho-sugar transferases [53447] (1)
      1. Nucleotide-diphospho-sugar transferases [53448] (1)
        1. CMP acylneuraminate synthetase [53455] (1)
          1. CMP acylneuraminate synthetase [53456]
            1. Neisseria meningitidis [53457] (4) picpic
  4. Alpha and beta proteins (a+b) [53931] (6)
    Mainly antiparallel beta sheets (segregated alpha and beta regions)
    1. beta-Grasp (ubiquitin-like) [54235] (1)
      1. Superantigen toxins, C-terminal domain [54334] (1)
        1. Superantigen toxins, C-terminal domain [54335] (1)
          1. Staphylococcal enterotoxin B, SEB [54342]
            1. Staphylococcus aureus [54343] (1) picpic
    2. GroEL-intermediate domain like [54848] (1)
      1. GroEL-intermediate domain like [54849] (1)
        1. Group II chaperonin (CCT, TRIC), intermediate domain [54853] (1)
          1. Thermosome, I domain [54854]
            1. Archaeon Thermoplasma acidophilum [54855] (4) picpic
    3. Ferredoxin-like [54861] (1)
      1. Pseudouridine synthase [55120] (3)
        1. Pseudouridine synthase I [55121] (1)
          1. Pseudouridine synthase I [55122]
            1. Escherichia coli [55123] (4) picpic
        2. Pseudouridine synthase II TruB [69746] (1)
          1. Pseudouridine synthase II TruB [69747]
            1. Escherichia coli [69748] (2) picpic
        3. Ribosomal small subunit pseudouridine 516 synthase RsuA [75459] (1)
          1. Ribosomal small subunit pseudouridine 516 synthase RsuA [75460]
            1. Escherichia coli [75461] (6) picpic
    4. DCoH-like [55247] (1)
      1. Hypothetical protein Yml108w [89975] (1)
        1. Hypothetical protein Yml108w [89976] (1)
          1. Hypothetical protein Yml108w [89977]
            1. Baker's yeast (Saccharomyces cerevisiae) [89978] (1) picpic
    5. SH2-like [55549] (1)
      1. SH2 domain [55550] (1)
        1. SH2 domain [55551] (1)
          1. Tyrosine-protein kinase zap-70 [89996]
            1. Human (Homo sapiens) [89997] (1) picpic
    6. Thymidylate synthase/dCMP hydroxymethylase [55830] (1)
      1. Thymidylate synthase/dCMP hydroxymethylase [55831] (1)
        1. Thymidylate synthase/dCMP hydroxymethylase [55832] (1)
          1. Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, TS domain [55841]
            1. Malaria parasite (Plasmodium falciparum) [88964] (2) picpic
  5. Multi-domain proteins (alpha and beta) [56572] (5)
    Folds consisting of two or more domains belonging to different classes
    1. DNA/RNA polymerases [56671] (1)
      1. DNA/RNA polymerases [56672] (1)
        1. Lesion bypass DNA polymerase (Y-family) [64477] (3)
          1. DinB homolog (DBH) [64478]
            1. Archaeon Sulfolobus solfataricus, DNA polymerase IV [69879] (2) picpic
            2. Archaeon Sulfolobus solfataricus [64479] (4) picpic
          2. DNA polymerase eta [69880]
            1. Baker's yeast (Saccharomyces cerevisiae) [69881] (2) picpic
    2. beta and beta-prime subunits of DNA dependent RNA-polymerase [64483] (1)
      1. beta and beta-prime subunits of DNA dependent RNA-polymerase [64484] (2)
        1. RNA-polymerase beta [64485] (1)
          1. RBP1 [64486]
            1. Baker's yeast (Saccharomyces cerevisiae) [64487] (4) picpic
        2. RNA-polymerase beta-prime [64490] (1)
          1. RBP2 [64491]
            1. Baker's yeast (Saccharomyces cerevisiae) [64492] (4) picpic
    3. DNA primase [56746] (1)
      1. DNA primase [56747] (1)
        1. DNA primase [56748] (1)
          1. DNA primase [56749]
            1. Archaeon Pyrococcus furiosus [56750] (2) picpic
    4. Ku heterodimer subunits [64500] (1)
      1. Ku heterodimer subunits [64501] (2)
        1. Ku70 subunit [64502] (1)
          1. Ku70 subunit [68905]
            1. Human (Homo sapiens) [64504] (2) picpic
        2. Ku80 subunit [64505] (1)
          1. Ku80 subunit [64506]
            1. Human (Homo sapiens) [64507] (2) picpic
    5. Heat shock protein 70kD (HSP70), C-terminal substrate-binding fragment [56777] (1)
      1. Heat shock protein 70kD (HSP70), C-terminal substrate-binding fragment [56778] (1)
        1. Heat shock protein 70kD (HSP70), C-terminal substrate-binding fragment [56779] (2)
          1. DnaK [56780]
            1. Escherichia coli [56781] (7) picpic
            2. Rat (Rattus norvegicus) [56782] (2) picpic
  6. Small proteins [56992] (3)
    Usually dominated by metal ligand, heme, and/or disulfide bridges
    1. Ovomucoid/PCI-1 like inhibitors [57466] (1)
      1. Ovomucoid/PCI-1 like inhibitors [57467] (2)
        1. Animal Kazal-type inhibitors [57468] (13)
          1. Ovomucoid III domain [57469]
            1. Turkey (Meleagris gallopavo) [57470] (20) picpic
            2. Japanese quail (Coturnix coturnix japonica) [57471] (5) picpic
            3. Silver pheasant (Lophura nycthemera) [57472] (4) picpic
          2. Secretory trypsin inhibitor [57473]
            1. Human (Homo sapiens) [57474] (3) picpic
            2. Pig (Sus scrofa) [57475] (1) picpic
          3. Blood-sucking insect-derived tryptase inhibitor [57476]
            1. Bug (Rhodnius prolixus), rhodniin [57477] (8) picpic
          4. Dipetalin [75676]
            1. Dipetalogaster maximus, dipetalin [75677] (1) picpic
          5. Domain of BM-40/SPARC/osteonectin [57478]
            1. Human (Homo sapiens) [57479] (4) picpic
          6. Domain of follistatin [90166]
            1. Rat (Rattus norvegicus) [90167] (3) picpic
          7. Seminal plasma inhibitor IIa [57480]
            1. Cow (Bos taurus) [57481] (2) picpic
          8. PEC-60 peptide [57482]
            1. Pig (Sus scrofa) [57483] (1) picpic
          9. Leech derived tryptase inhibitor (LDTI-C) [57484]
            1. Medicinal leech (Hirudo medicinalis) [57485] (2) picpic
          10. Ascidian trypsin inhibitor [75678]
            1. Sea squirt (Halocynthia roretzi) [75679] (1) picpic
        2. Plant proteinase inhibitors [57486] (3)
          1. Plant chymotrypsin inhibitor [57487]
            1. Potato tuber (Solanum tuberosum) [57488] (1) picpic
          2. Multidomain proteinase inhibitor [57489]
            1. Winged tobacco (Nicotiana alata) [57490] (5) picpic
          3. Wound-induced proteinase inhibitor-II [90168]
            1. Tomato (Lycopersicon esculentum) [90169] (1) picpic
    2. Serine proteinase inhibitor lekti [69958] (1)
      1. Serine proteinase inhibitor lekti [69959] (1)
        1. Serine proteinase inhibitor lekti [69960] (1)
          1. Serine proteinase inhibitor lekti [69961]
            1. Human (Homo sapiens) [69962] (2) picpic
    3. Zinc-binding domain of translation initiation factor 2 beta [75688] (1)
      1. Zinc-binding domain of translation initiation factor 2 beta [75689] (1)
        1. Zinc-binding domain of translation initiation factor 2 beta [75690] (1)
          1. Zinc-binding domain of translation initiation factor 2 beta [75691]
            1. Archaeon Methanococcus jannaschii [75692] (1) picpic
  7. Peptides [58231] (6)
    Peptides and fragments. Not a true class
    1. Antimicrobial beta-hairpin [58251] (1)
      1. Antimicrobial beta-hairpin [58252] (1)
        1. Leucocin [58253] (1)
          1. Leucocin [58254]
            1. Leuconostoc gelidum [58255] (3) picpic
    2. Antimicrobial helix [58268] (1)
      1. Antimicrobial helix [58269] (1)
        1. Carnobacteriocin B2 [58275] (1)
          1. Carnobacteriocin B2 [58276]
            1. Carnobacterium piscicola [58277] (1) picpic
    3. Arg-rich RNA binding peptides [58321] (1)
      1. RSG-1.2 peptide [58330] (1)
        1. RSG-1.2 peptide [58331] (1)
          1. RSG-1.2 peptide [58332]
            1. Human immunodeficiency virus type 1 [58333] (1) picpic
    4. Transmembrane helical fragments [58517] (1)
      1. Transmembrane helical fragments [58518] (1)
        1. Transmembrane helical fragments [58519] (1)
          1. F1F0 ATP synthase subunit c [58534]
            1. Escherichia coli [58535] (2) picpic
    5. MoMLV p15 fragment (residues 409-426) [58624] (1)
      1. MoMLV p15 fragment (residues 409-426) [58625] (1)
        1. MoMLV p15 fragment (residues 409-426) [58626] (1)
          1. MoMLV p15 fragment (residues 409-426) [58627]
            1. Molomey murine leukaemia virus, MoMLV [58628] (1) picpic
    6. Integrin fragments [58697] (1)
      1. Integrin fragments [58698] (1)
        1. Integrin fragments [58699] (1)
          1. Membrane proximal regions of alpha-iib and beta-3 integrins [75747]
            1. Synthetic [75748] (2) picpic
  8. Designed proteins [58788] (3)
    Experimental structures of proteins with essentially non-natural sequences. Not a true class
    1. Collagen-like peptides [58805] (1)
      1. Collagen-like peptides [58806] (1)
        1. Collagen-like peptides [58807] (1)
          1. Collagen-like peptides [58808]
            1. Synthetic (contains biological sequence) [58811] (3) picpic
    2. VaLd trimeric coiled-coil [58817] (1)
      1. VaLd trimeric coiled-coil [58818] (1)
        1. VaLd trimeric coiled-coil [58819] (1)
          1. VaLd trimeric coiled-coil [58820]
            1. Synthetic [58821] (1) picpic
    3. Designed trimeric coiled-coil peptide [64664] (1)
      1. Designed trimeric coiled-coil peptide [64665] (1)
        1. Designed trimeric coiled-coil peptide [64666] (2)
          1. Designed trimeric coiled-coil peptide [64667]
            1. Synthetic, design-1 [64668] (12) picpic
            2. Synthetic, design-2 [75766] (1) picpic
Enter search key:
Generated from scop database 1.65_1.67 history with scopm 1.100 on Mon Feb 7 15:33:01 2005
Copyright © 1994-2005 The scop authors / scop@mrc-lmb.cam.ac.uk