Class: All alpha proteins

Lineage:

1. Root: scop
2. Class: All alpha proteins [46456]

Folds:

1. Globin-like [46457] (2)
   core: 6 helices; folded leaf, partly opened
2. Long alpha-hairpin [46556] (12)
   2 helices; antiparallel hairpin, left-handed twist
3. Type I dockerin domain [63445] (1)
   tandem repeat of two calcium-binding loop-helix motifs, distinct from the EF-hand
4. LEM/SAP HeH motif [63450] (4)
   helix-extended loop-helix; parallel helices
5. Cytochrome c [46625] (1)
   core: 3 helices; folded leaf, opened
6. DNA/RNA-binding 3-helical bundle [46688] (12)
   core: 3-helices; bundle, closed or partly opened, right-handed twist; up-and down
7. Another 3-helical bundle [81602] (3)
   topologically similar to the DNA/RNA-binding bundles; distinct packing
8. RuvA C-terminal domain-like [46928] (6)
   3 helices; bundle, right-handed twist
9. S13-like H2TH domain [81297] (1)
   core: 3-4 helices
10. Putative DNA-binding domain [46954] (1)
    core: 3 helices; architecture is similar to that of the "winged helix" fold but topology is different
11. Spectrin repeat-like [46965] (9)
    3 helices; bundle, closed, left-handed twist; up-and-down
12. immunoglobulin/albumin-binding domain-like [46996] (6)
    3 helices; bundle, closed, left-handed twist; up-and-down; mirror topology to the spectrin-like fold
13. Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex [47004] (1)
    3 helices; bundle, closed, right-handed twist; up-and-down
14. Protozoan pheromone proteins [47013] (1)
    3 helices; bundle, closed, left-handed twist, up-and-down
15. Acyl-CoA binding protein-like [47026] (2)
    core: 3 helices; bundle, closed, left-handed twist; up-and-down
16. Kix domain of CBP (creb binding protein) [47039] (1)
    3 helices; bundle, partly opened
17. alpha-2-Macroglobulin receptor associated protein (RAP) domain 1 [47044] (1)
    3 helices, the first one is shorter than the other two; bundle, partly opened
18. VHP, Villin headpiece domain [47049] (1)
    3 short helices; irregular array
19. TAF(II)230 TBP-binding fragment [47054] (1)
    3 short helices; irregular array
20. S15/NS1 RNA-binding domain [47059] (1)
    3 helices; irregular array
21. p8-MTCP1 [47071] (1)
    3 helices; irregular array; disulfide-rich
22. Frizzled cysteine-rich domain [63500] (1)
    Core: 3 helices; irregular array; disulfide-rich
23. T4 endonuclease V [47076] (1)
    3 helices; irregular array
24. Fertilization protein [47081] (1)
    core: 3 helices; bundle, closed, right-handed twist; up-and-down
25. PGBD-like [47089] (1)
    core: 3 helices; bundle, closed, left-handed twist; parallel
26. HMG-box [47094] (1)
    3 helices; irregular array
27. Histone-fold [47112] (1)
    core: 3 helices; long middle helix is flanked at each end with shorter ones
28. Open three-helical up-and-down bundle [47143] (5)
    core: 3 helices; bundle, open
29. beta-catenin-interacting protein ICAT [81729] (1)
    core: 3 helices; irregular array
30. Four-helical up-and-down bundle [47161] (20)
    core: 4 helices; bundle, closed or partly opened, left-handed twist; up-and-down
31. PTS-regulatory domain, PRD [63519] (1)
    core: 4 helices; bundle, closed, right-handed twist; 1 crossover connection
32. Ferritin-like [47239] (2)
    core: 4 helices; bundle, closed, left-handed twist; 1 crossover connection
33. 4-helical cytokines [47265] (1)
    core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections
34. Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases [47322] (1)
    core: 4 helices; bundle; one loop crosses over one side of the bundle
35. Acyl carrier protein-like [47335] (3)
    4 helices, bundle; helix 3 is shorter than others; up-and-down
36. Bromodomain-like [47363] (5)
    4 helices; bundle; minor mirror variant of up-and-down topology
37. ROP-like [47379] (4)
    4 helices; dimer of identical alpha-hairpin subunits; bundle, closed, left-handed twist
38. Dimerization-anchoring domain of cAMP-dependent type II PK regulatory subunit [47390] (1)
    4 helices; bundle, closed, right-handed twist
39. Soluble domain of poliovirus core protein 3a [89042] (1)
    4 helices; bundle, closed, right-handed twist
40. Transcription factor IIA (TFIIA), alpha-helical domain [47395] (1)
    4 helices; bundle, closed, right-handed twist
41. Ectatomin subunits [47400] (1)
    4 helices; bundle, closed, left-handed twist
42. Dimerisation interlock [47405] (3)
    4 helices; bundle, closed, right-handed twist
43. lambda repressor-like DNA-binding domains [47412] (1)
    core: 4 helices; folded leaf, closed
44. Signal peptide-binding domain [47445] (1)
    4 helices; orthogonal array
45. A DNA-binding domain in eukaryotic transcription factors [47453] (1)
    4 helices; the long C-terminal helix protrudes from the domain and binds to DNA
46. HLH-like [47458] (2)
    4-helices; bundle, closed, left-handed twist; 2 crossover connections
47. EF Hand-like [47472] (4)
    core: 4 helices; array of 2 hairpins, opened
48. CH domain-like [47575] (2)
    core: 4 helices: bundle
49. Domain of poly(ADP-ribose) polymerase [47586] (1)
    core: 4 helices: bundle; unusual topology
50. SWIB/MDM2 domain [47591] (1)
    core: 4 helices: open bundle; capped by two small 3-stranded beta-sheets
    duplication: consists of two structural repeats
51. Pre-protein crosslinking domain of SecA [81766] (1)
    core: 4 helices: bundle; flanked by two short beta-hairpins
    duplication: consists of two structural repeats
52. Ribbon-helix-helix [47597] (1)
    core: 4 helices; array of 2 hairpins, opened
53. Glutathione S-transferase (GST), C-terminal domain [47615] (1)
    core: 4 helices; bundle, closed, left-handed twist; right-handed superhelix
54. Methionine synthase domain-like [47643] (2)
    4 helices; bundle, left-handed twist; right-handed superhelix
55. Circadian clock protein KaiA, C-terminal domain [101214] (1)
    4 helices; bundle, right-handed twist; right-handed superhelix
56. STAT-like [47654] (2)
    4 long helices; bundle, left-handed twist (coiled coil); right-handed superhelix
57. N-cbl like [47667] (3)
    4 helices; bundle, left-handed twist; left-handed superhelix
58. Replisome organizer (g39p helicase loader/inhibitor protein) [89063] (1)
    4 helices; bundle, right-handed twist; left-handed superhelix
59. C-terminal domain of B transposition protein [47680] (1)
    4 helices; irregular array
60. RNA polymerase omega subunit [63561] (1)
    4 helices; irregular array
61. HAND domain of the nucleosome remodeling ATPase ISWI [101223] (1)
    4 helices; irregular array
62. N-terminal, cytoplasmic domain of anti-sigmaE factor RseA [89068] (1)
    4 helices; irregular array
63. Anaphylotoxins (complement system) [47685] (1)
    4 helices; irregular array, disulfide-linked
64. Cytochrome c oxidase subunit h [47693] (1)
    4 helices; irregular array, disulfide-linked
65. Crustacean CHH/MIH/GIH neurohormone [81777] (1)
    4 helices; irregular array, disulfide-linked
66. C-terminal domain of DFF45/ICAD (DFF-C domain) [81782] (1)
    4 helices; folded leaf; right-handed superhelix
67. Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin [47698] (1)
    4 helices; folded leaf; right-handed superhelix
68. p53 tetramerization domain [47718] (1)
    core: 4 helices; bundle
69. Bcr-Abl oncoprotein oligomerization domain [69035] (1)
    core: 4 long helices; bundle
70. Domain of early E2A DNA-binding protein, ADDBP [47723] (1)
    4 helices; bundle, partly opened
71. IHF-like DNA-binding proteins [47728] (1)
    core: 4 helices; bundle, partly opened, capped with a beta-sheet
72. CO dehydrogenase ISP C-domain like [47740] (1)
    core: 4 helices, bundle
73. Protein HNS-dependent expression A; HdeA [47751] (1)
    4 helices; the three last helices form a bundle similar to that of the RuvA C-domain
74. PABP domain-like [63569] (2)
    4 helices; an orthogonal array
75. Chemotaxis receptor methyltransferase CheR, N-terminal domain [47756] (1)
    4 helices; an orthogonal array
76. PWI domain [101232] (1)
    4 helices; up-and-down bundle; topological similarity to the bromodomain-like and SAM domain-like folds
77. PAH2 domain [47761] (1)
    4 helices; open up-and-down bundle; binds alpha-helical peptides
78. Myosin phosphatase inhibitor 17kDa protein, CPI-17 [81789] (1)
    4 helices; open up-and-down bundle; flexible N-terminal tail
79. XPC-binding domain of Rad23 homolog A (Hhr23a) [101237] (1)
    4 helices; array
80. SAM domain-like [47768] (13)
    4-5 helices; bundle of two orthogonally packed alpha-hairpins; involved in the interactions with DNA and proteins
81. Retroviral matrix proteins [47835] (1)
    4-5 helices; right-handed superhelix
82. Flavivirus capsid protein C [101256] (1)
    core: 5 helices; right-handed superhelix; swapped dimer with the two long C-terminal helices
83. Hepatitis B viral capsid (hbcag) [47851] (1)
    5 helices; array; two long helices form a hairpin that dimerizes into a 4-helical bundle
84. Apolipophorin-III [47856] (1)
    5 helices; bundle, closed, left-handed twist
85. Methenyltetrahydrofolate cyclohydrolase-like [101261] (1)
    5 helices; bundle, closed, left-handed twist
86. Saposin-like [47861] (2)
    5 helices; folded leaf, closed
87. Annexin [47873] (1)
    5 helices; folded leaf, closed
88. Transducin (alpha subunit), insertion domain [47894] (1)
    5 helices; folded leaf
89. Wiscott-Aldrich syndrome protein, WASP, C-terminal domain [47911] (1)
    5 helices; irregular array; left-handed superhelix
90. Left-handed superhelix [47916] (3)
    core: 4-5 helices; bundle; left-handed superhelix
91. N-terminal domain of the delta subunit of the F1F0-ATP synthase [47927] (1)
    core: 5 helices; bundle
92. ERP29 C domain-like [47932] (2)
    5 helices; bundle
93. Functional domain of the splicing factor Prp18 [47937] (1)
    core: 5 helices; bundle
94. Retrovirus capsid protein, N-terminal core domain [47942] (1)
    core: 5 helices; bundle
95. Cyclin-like [47953] (1)
    core: 5 helices; one helix is surrounded by the others
96. Arp2/3 complex 21 kDa subunit ARPC3 [69059] (1)
    5 helices; one helix is surrounded by the others
97. RNase III endonuclease catalytic domain [69064] (1)
    core: 5 helices; one helix is surrounded by the others
98. Ribosomal protein S7 [47972] (1)
    core: 5 helices; contains one more helix and a beta-hairpin outside the core
99. DNA polymerase III clamp loader subunits, C-terminal domain [48018] (1)
    core: 5 helices: bundle
100. PAP/OAS1 substrate-binding domain [81632] (1)
     core: 5-helical bundle; up-and-down; right-handed twist
101. Anti-sigma factor AsiA [69069] (1)
     core: 5 helices: orthogonal array
102. Antibiotic binding domain of TipA-like multidrug resistance regulators [89081] (1)
     5 helices: orthogonal array
103. N-terminal domain of adenylylcyclase associated protein, CAP [101277] (1)
     6 helices: bundle; left-handed twist, up-and-down topology
104. Iron-dependent repressor protein, dimerization domain [47978] (1)
     6 helices, homodimer of 3-helical domains
105. Glutamyl tRNA-reductase dimerization domain [69074] (1)
     6 helices, homodimer of 3-helical domains
106. GRIP domain [101282] (1)
     6 helices, homodimer of 3-helical domains
107. L27 domain [101287] (1)
     6 helices, heterodimer of 3-helical domains
108. DEATH domain [47985] (1)
     6 helices: closed bundle; greek-key; internal pseudo twofold symmetry
109. Fatty acid responsive transcription factor FadR, C-terminal domain [48007] (1)
     core: 6 helices: closed bundle; greek-key; internal pseudo twofold symmetry
110. NusB-like [48012] (1)
     6 helices: bundle; one central helix is surrounded by 5 others
111. YutG-like [101306] (1)
     core: 6 helices; bundle; one central helix is surrounded by 5 others
112. N-terminal domain of DnaB helicase [48023] (1)
     6 helices: array
113. Invasion protein A (SipA) , C-terminal actin binding domain [101311] (1)
     6 helices: orthogonal array
114. Guanido kinase N-terminal domain [48033] (1)
     irregular array of 6 short helices
115. Scaffolding protein gpD of bacteriophage procapsid [48044] (1)
     core: 6 helices; one central helix is surrounded by 5 others
116. Hypothetical protein Aq_328 [101316] (1)
     core: 6 helices; one central helix is surrounded by 5 others
117. Hemocyanin, N-terminal domain [48049] (1)
     6 helices; bundle; one central helix is surrounded by 5 others
118. Di-copper centre-containing domain [48055] (1)
     multihelical
119. DBL homology domain (DH-domain) [48064] (1)
     multihelical; core: 5-helical bundle
120. LigA subunit of an aromatic-ring-opening dioxygenase LigAB [48075] (1)
     multihelical; contains compact array of 6 short helices
121. RuBisCo LSMT C-terminal, substrate-binding domain [81821] (1)
     multihelical; irregular array of long and short helices
122. Porin chaperone SurA, peptide-binding domain [81826] (1)
     multihelical; irregular array of long and short helices
123. Methyl-coenzyme M reductase alpha and beta chain C-terminal domain [48080] (1)
     multihelical bundle; contains buried central helix
124. YcfC-like [101321] (1)
     multihelical; contains two buried central helices
125. Transcription factor STAT-4 N-domain [48091] (1)
     multihelical; can be divided into two subdomains
126. Regulator of G-protein signaling, RGS [48096] (1)
     multihelical; consists of two all-alpha subdomains
     contains a 4-helical bundle with left-handed twist and up-and-down topology
127. GEF domain of SopE toxin [81831] (1)
     multihelical; consists of two all-alpha subdomains each containing a 3-helical bundle with right-handed twist
128. Variable surface antigen VlsE [74747] (1)
     multihelical; consists of two all-alpha subdomains; contains a 4-helical bundle with left-handed twist and up-and-down topology
129. YgfB-like [101326] (1)
     multihelical; consists of two tightly associated 3-helical bundles with different twists
130. Hypothetical protein MTH393 [101331] (1)
     multihelical; consists of two all-alpha subdomains; dimer
131. Carbamoyl phosphate synthetase, large subunit connection domain [48107] (1)
     multihelical; consists of two all-alpha subdomains
     possible duplication: subdomains have similar topologies
132. Heme-dependent peroxidases [48112] (1)
     multihelical; consists of two all-alpha domains
133. Ribosomal protein L19 (L19e) [48139] (1)
     multihelical; consists of two different 3-helical domains connected by a long, partly helical linker
134. GatB/YqeY domain [89094] (1)
     multihelical; consists of two different alpha-helical bundles (4-helical and 3-helical)
135. HD domain [101338] (1)
     multihelical; consists of two different alpha-helical bundles
136. Superantigen MAM [101343] (1)
     multihelical; consists of two different alpha-helical bundles
137. Influenza virus matrix protein M1 [48144] (1)
     multihelical; consists of two different all-alpha subdomains, 4 helices each
138. DNA-glycosylase [48149] (1)
     multihelical; consists of two all-alpha domains
139. An anticodon-binding domain of class I aminoacyl-tRNA synthetases [48162] (1)
     multihelical; consists of two all-alpha domains
140. Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) [101352] (1)
     multihelical; consists of two all-alpha subdomains
141. R1 subunit of ribonucleotide reductase, N-terminal domain [48167] (1)
     multihelical consists of two all-alpha subdomains
     subdomain 1 (residues 10-100) is a 4-helical bundle
142. BEACH domain [81836] (1)
     multihelical, complex architecture
143. Cryptochrome/photolyase FAD-binding domain [48172] (1)
     multihelical; consists of two all-alpha subdomains
144. 6-phosphogluconate dehydrogenase C-terminal domain-like [48178] (1)
     multihelical; common core is formed around two long antiparallel helices related by (pseudo) twofold symmetry
145. Uteroglobin-like [48200] (1)
     multihelical
146. alpha/alpha toroid [48207] (5)
     multihelical; up to seven alpha-hairpins are arranged in closed circular array; there may be sequence similarities between different superfamilies
147. Citrate synthase [48255] (1)
     multihelical; consists of two all-alpha domains
148. Cytochrome P450 [48263] (1)
     multihelical
149. Flagellar transcriptional activator FlhD [63591] (1)
     multihelical; forms intertwined dimer of identical 5-helical subunits
150. Ribosomal protein L7/12, oligomerisation (N-terminal) domain [48299] (1)
     multihelical; intertwined tetramer
151. Class II MHC-associated invariant chain ectoplasmic trimerization domain [48304] (1)
     multihelical; intertwined trimer of identical 3-helical subunits
152. Aldehyde ferredoxin oxidoreductase, C-terminal domains [48309] (1)
     multihelical; consists of two all-alpha domains
153. Acid phosphatase/Vanadium-dependent haloperoxidase [48316] (1)
     multihelical; core: 5-helical bundle; binds cofactor at the beginning of third helix
154. BRCA2 helical domain [81871] (1)
     multihelical; contains a 3-helical bundle surrounded by several shorter helices
155. BRCA2 tower domain [81877] (1)
     multihelical; contains a 3-helical Hin recombinase-like subdomain and two long dimerisation helices
156. H-NS histone-like proteins [81274] (1)
     multihelical oligomeric protein; structure of whole subunit is not known yet but are probably composed of three different domains
157. Sigma2 domain of RNA polymerase sigma factors [88945] (1)
     multihelical; consists of a conserved 4-helical core and a variable insert subdomain
158. DNA repair protein MutS, domain III [48333] (1)
     multihelical; consists of 2 all-alpha subdomains
159. Helical scaffold and wing domains of SecA [81885] (1)
     multihelical; consists of 2 all-alpha subdomains
160. Type II deoxyuridine triphosphatase [101385] (1)
     multihelical; consists of 2 all-alpha subdomains, "rigid" one and "mobile" one
161. Hsp90 co-chaperone CDC37 [101390] (1)
     multihelical; consists of 2 all-alpha subdomains connected by a long helix
162. Nop domain [89123] (1)
     multihelical; array of longer and shorter helices; contains an alpha-hairpin dimerisation subdomain
163. Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain [48339] (1)
     multihelical; bundle of longer and shorter helices
164. A virus capsid protein alpha-helical domain [48344] (1)
     multihelical; three-helical bundle in the core is surrounded by non-conserved helices
165. P40 nucleoprotein [101398] (1)
     multihelical; consists of two subdomains
166. GTPase activation domain, GAP [48349] (1)
     multihelical
167. Ras GEF [48365] (1)
     multihelical
168. Telomeric repeat binding factor (TRF) dimerisation domain [63599] (1)
     multihelical; can be divided into an alpha-alpha superhelix domain and a long alpha-hairpin dimerization domain
169. tRNA CCA-adding enzyme, C-terminal domains [81890] (1)
     multihelical; can be divided into three subdomains (neck, body and tail)
170. alpha-alpha superhelix [48370] (20)
     multihelical; 2 (curved) layers: alpha/alpha; right-handed superhelix
171. Lipoxigenase [48483] (1)
     multihelical
     large nearly all-alpha domain
172. gene 59 helicase assembly protein [48492] (1)
     multihelical; consists of two all-alpha subdomains
173. Tetracyclin repressor-like, C-terminal domain [48497] (1)
     multihelical; interlocked (homo)dimer
174. Skp1 dimerisation domain-like [81384] (1)
     multihelical; interlocked heterodimer with F-box proteins
175. F-box domain [81385] (1)
     multihelical; interlocked heterodimer with the Skp1 dimerisation domain
176. Nuclear receptor ligand-binding domain [48507] (1)
     multihelical; 3 layers or orthogonally packed helices
177. Phospholipase C/P1 nuclease [48536] (1)
     multihelical
178. PDEase [48546] (1)
     multihelical; can be divided into three subdomains
179. Serum albumin-like [48551] (1)
     multihelical; one domain consists of two similar disulfide-linked subdomains
180. L-aspartase-like [48556] (1)
     multihelical, consists of three all-alpha domains
181. Formin homology 2 domain (FH2 domain) [101446] (1)
     multihelical, consists of three all-alpha domains
182. Terpenoid synthases [48575] (1)
     multihelical; core: 8 helices (C-J) are arranged in 2 parallel layers
183. GroEL equatorial domain-like [48591] (1)
     multihelical; 8 helices arranged in 2 parallel layers
184. TorA specific chaperone TorD [89154] (1)
     multihelical; bundle
185. Chorismate mutase II [48599] (1)
     multihelical; core: 6 helices, bundle
186. Peridinin-chlorophyll protein [48607] (1)
     multihelical: forms a boat-shaped protein shell around cofactors
187. Heme oxygenase-like [48612] (1)
     multihelical; bundle
188. AhpD-like [69117] (1)
     multihelical; contains 4-helical bundle and 2-helical arm
189. Double Clp-N motif [81922] (1)
     multihelical; array
190. Orange carotenoid protein, N-terminal domain [81929] (1)
     multihelical; array
191. Citrobacter dihydroxyacetone kinase extra ATP-binding domain [101472] (1)
     multihelical; bundle
192. ADP-ribosylglycohydrolase [101477] (1)
     multihelical; bundle
193. Gametocyte protein Pfg27 [89161] (1)
     multihelical; bundle
194. N-terminal domain of bifunctional PutA protein [81934] (1)
     multihelical; array
195. Phospholipase A2, PLA2 [48618] (1)
     common core: 2 helices, disulfide-linked, and a calcium-binding loop
196. Fungal elicitin [48646] (1)
     5 helices: irregular disulfide-linked array; also contains a small beta-hairpin
197. Tetraspanin [48651] (1)
     5 helices: irregular disulfide-linked array; form homodimer
198. Repressor of bacterial conjugation FinO [48656] (1)
     6 helices: irregular non-globular array; also contains two small b-hairpins
199. Nuclear receptor coactivator interlocking domain [69124] (1)
     3 helices, non-globular array; forms interlocked heterodimers with its targets
200. Eukaryotic initiation factor 4f subunit eIF4g, eIF4e-binding domain [101488] (1)
     5 helices, non-globular array; wraps around the N-terminal tail of its target
201. Non-globular all-alpha subunits of globular proteins [48661] (10)
     not a true fold
202. Multiheme cytochromes [48694] (1)
     variable number of helices and little beta structure; not a true fold