Superfamily: C2 domain (Calcium/lipid-binding domain, CaLB)

two constituent families are related by circular permutation

Lineage:

1. Root: scop
2. Class: All beta proteins
3. Fold: C2 domain-like
   sandwich; 8 strands in 2 sheets; greek-key
4. Superfamily: C2 domain (Calcium/lipid-binding domain, CaLB)
   two constituent families are related by circular permutation

Families:

1. PLC-like (P variant) (7)
2. Synaptotagmin-like (S variant) (4)
   topologically similar to the C-terminal domain of PapD