Fold: Snake toxin-like

disulphide-rich fold: nearly all-beta

Lineage:

1. Root: scop
2. Class: Small proteins
   Usually dominated by metal ligand, heme, and/or disulfide bridges
3. Fold: Snake toxin-like
   disulphide-rich fold: nearly all-beta

Superfamilies:

1. Snake toxin-like (3)
   1. Snake venom toxins (26)
      1. Erabutoxin B (also neurotoxin B)
         1. Sea snake (Laticauda semifasciata) (7)
      2. gamma-Cardiotoxin
         1. Snake (Naja nigricollis) (3)
      3. Fasciculin
         different isoforms
         1. Green mamba (Dendroaspis angusticeps) (7)
      4. Erabutoxin A
         1. Broad-banded blue sea snake (Laticauda semifasciata) (3)
      5. Neurotoxin I
         1. Snake (Naja naja oxiana) (1)
      6. Cardiotoxin V4II (Toxin III)
         1. Naja mossambica mossambica (1)
      7. Cardiotoxin V
         1. Taiwan cobra (Naja naja atra) (2)
      8. alpha-Cobratoxin
         1. Cobra (Naja naja siamensis) (2)
      9. Long neurotoxin 1 (component LSIII)
         1. Sea snake (Laticauda semifasciata) (1)
      10. FS2 toxin
          1. Black mamba (Dendroaspis polylepis polylepis) (1)
      11. Bungarotoxin
          1. Alpha-bungarotoxin (Bungarus multicinctus) (6)
          2. Kappa-bungarotoxin (Bungarus multicinctus) (1)
          3. Neuronal bungarotoxin (Bungarus multicinctus) (1)
      12. Bucandin
          1. Malayan krait (Bungarus candidus) (1)
      13. Cardiotoxin CTXI
          1. Taiwan cobra (Naja naja atra) (1)
      14. Cardiotoxin CTX IIB
          1. Naja mossambica mossambica (1)
      15. Cardiotoxin II
          1. Taiwan cobra (Naja naja atra) (3)
          2. Central asian cobra (Naja naja oxiana) (3)
      16. Cardiotoxin III
          1. Taiwan cobra (Naja naja atra) (3)
      17. Cardiotoxin IV
          1. Taiwan cobra (Naja naja atra) (2)
      18. Cobrotoxin II (ct2)
          1. Taiwan cobra (Naja naja atra) (2)
          2. Monocled cobra (Naja kaouthia) (1)
      19. alpha-Toxin
          1. Snake (Naja nigricollis) (1)
          2. Black mamba (Dendroaspis polylepis polylepis) (1)
      20. Neurotoxin II
          1. Central asian cobra (Naja naja oxiana) (1)
      21. Toxin B (long neurotoxin)
          1. King cobra (Ophiophagus hannah) (2)
   2. Dendroaspin (1)
      1. Dendroaspin
         lacks neurotoxicity; acts as the disintegrins: contains RGD-motif
         1. Dendroaspis jamesoni kaimosae (1)
   3. Extracellular domain of cell surface receptors (3)
      1. CD59
         1. Human (Homo sapiens) (5)
      2. Type II activin receptor
         1. Mouse (Mus musculus) (1)
      3. BMP receptor Ia ectodomain
         1. Human (Homo sapiens) (1)