Fold: Knottins (small inhibitors, toxins, lectins)

disulphide-bound fold; contains beta-hairpin with two adjacent disulphides

Lineage:

1. Root: scop
2. Class: Small proteins
   Usually dominated by metal ligand, heme, and/or disulfide bridges
3. Fold: Knottins (small inhibitors, toxins, lectins)
   disulphide-bound fold; contains beta-hairpin with two adjacent disulphides

Superfamilies:

1. Plant lectins/antimicrobial peptides (2)
2. Plant inhibitors of proteinases and amylases (1)
3. Cyclotides (3)
   macrocyclic plant knottins closed with the formation of an Asn-Gly peptide
4. Gurmarin-like (2)
5. Agouti-related protein (1)
6. omega toxin-like (2)
7. Scorpion toxin-like (5)
8. Cellulose-binding domain (1)
9. IGF binding domain (1)
10. Colipase-like (1)
11. EGF/Laminin (4)
12. Bromelain inhibitor VI (cysteine protease inhibitor) (1)
13. Bowman-Birk inhibitor, BBI (1)
14. Elafin-like (1)
15. Leech antihemostatic proteins (2)
16. N-terminal domain of granulin-1 (1)