Fold: Nucleotidyltransferases

common catalytic domain is alpha+beta; 2 layers: a/b; mixed sheet

Lineage:

1. Root: scop
2. Class: Multi-domain proteins (alpha and beta)
   Folds consisting of two or more domains belonging to different classes
3. Fold: Nucleotidyltransferases
   common catalytic domain is alpha+beta; 2 layers: a/b; mixed sheet

Superfamilies:

1. Nucleotidyltransferases (3)
   1. DNA polymerase beta, catalytic (31 kD) fragment (2)
      catalytic domain is between all-alpha and alpha+beta domains
   2. Poly(A) polymerase, catalytic domain (2)
   3. Kanamycin nucleotidyltransferase (KNTase) (1)
      N-terminal catalytic domain is followed by an all-alpha domain