Superfamily: beta-Lactamase/D-ala carboxypeptidase

Lineage:

1. Root: scop
2. Class: Multi-domain proteins (alpha and beta)
   Folds consisting of two or more domains belonging to different classes
3. Fold: beta-Lactamase/D-ala carboxypeptidase
   contains a cluster of helices and an alpha+beta sandwich
4. Superfamily: beta-Lactamase/D-ala carboxypeptidase

Families:

1. beta-Lactamase/D-ala carboxypeptidase (19)
   1. D-ala carboxypeptidase/transpeptidase
      1. Streptomyces sp., K15 (7)
      2. Streptomyces sp., R61 (4)
   2. beta-Lactamase, class A
      1. Escherichia coli, TEM-1 (11)
      2. Escherichia coli, TOHO-1 (1)
      3. Klebsiella pneumoniae, SHV-1 (2)
      4. Pseudomonas aeruginosa, PSE-4 carbenicillinase (2)
      5. Staphylococcus aureus (13)
      6. Bacillus licheniformis (3)
      7. Enterobacter cloacae, NMC-A carbapenemase (2)
      8. Streptomyces albus G (1)
      9. Mycobacterium fortuitum (1)
      10. Pseudomonas aeruginosa, PER-1 (1)
      11. Serratia marcescens, Sme-1 (1)
          imipenem-hydrolyzing
   3. AMPC beta-Lactamase, class C
      contains small alpha+beta subdomain inserted in the common fold
      1. Citrobacter freundii (2)
      2. Enterobacter cloacae, P99, cephalosporinase (3)
      3. Escherichia coli, cephalosporinase (6)
   4. OXA-10 beta-lactamase, class D
      1. Pseudomonas aeruginosa (4)
   5. Penicillin-binding protein 2x (pbp-2x), transpeptidase domain
      1. Streptococcus pneumoniae (3)
   6. D-aminopeptidase, N-terminal domain
      1. Ochrobactrum anthropi (1)