Fold: beta-Lactamase/D-ala carboxypeptidase

contains a cluster of helices and an alpha+beta sandwich

Lineage:

1. Root: scop
2. Class: Multi-domain proteins (alpha and beta)
   Folds consisting of two or more domains belonging to different classes
3. Fold: beta-Lactamase/D-ala carboxypeptidase
   contains a cluster of helices and an alpha+beta sandwich

Superfamilies:

1. beta-Lactamase/D-ala carboxypeptidase (1)
   1. beta-Lactamase/D-ala carboxypeptidase (19)
      1. D-ala carboxypeptidase/transpeptidase
         1. Streptomyces sp., K15 (7)
         2. Streptomyces sp., R61 (4)
      2. beta-Lactamase, class A
         1. Escherichia coli, TEM-1 (11)
         2. Escherichia coli, TOHO-1 (1)
         3. Klebsiella pneumoniae, SHV-1 (2)
         4. Pseudomonas aeruginosa, PSE-4 carbenicillinase (2)
         5. Staphylococcus aureus (13)
         6. Bacillus licheniformis (3)
         7. Enterobacter cloacae, NMC-A carbapenemase (2)
         8. Streptomyces albus G (1)
         9. Mycobacterium fortuitum (1)
         10. Pseudomonas aeruginosa, PER-1 (1)
         11. Serratia marcescens, Sme-1 (1)
             imipenem-hydrolyzing
      3. AMPC beta-Lactamase, class C
         contains small alpha+beta subdomain inserted in the common fold
         1. Citrobacter freundii (2)
         2. Enterobacter cloacae, P99, cephalosporinase (3)
         3. Escherichia coli, cephalosporinase (6)
      4. OXA-10 beta-lactamase, class D
         1. Pseudomonas aeruginosa (4)
      5. Penicillin-binding protein 2x (pbp-2x), transpeptidase domain
         1. Streptococcus pneumoniae (3)
      6. D-aminopeptidase, N-terminal domain
         1. Ochrobactrum anthropi (1)