Fold: Type II DNA topoisomerase

4 domains: (1) toprim alpha/beta; (2) "winged helix"-like; (3) alpha+beta; (4) all-alpha

Lineage:

1. Root: scop
2. Class: Multi-domain proteins (alpha and beta)
   Folds consisting of two or more domains belonging to different classes
3. Fold: Type II DNA topoisomerase
   4 domains: (1) toprim alpha/beta; (2) "winged helix"-like; (3) alpha+beta; (4) all-alpha

Superfamilies:

1. Type II DNA topoisomerase (1)
   1. Type II DNA topoisomerase (2)
      domain 2 contains the catalytic tyrosine residue
      1. DNA topoisomerase II, C-terminal fragment (residues 410-1202)
         the N-terminal fragment is homologous to known structure of DNA gyrase B
         1. Baker's yeast (Saccharomyces cerevisiae) (2)
      2. DNA Gyrase A
         1. Escherichia coli (1)