Class: Alpha and beta proteins (a+b)

Mainly antiparallel beta sheets (segregated alpha and beta regions)

Lineage:

1. Root: scop
2. Class: Alpha and beta proteins (a+b)
   Mainly antiparallel beta sheets (segregated alpha and beta regions)

Folds:

1. Microbial ribonucleases (1)
   single helix packs against antiparallel beta-sheet
2. Lysozyme-like (1)
   common alpha+beta motif for the active site region
3. Cysteine proteinases (1)
   consists of one alpha-helix and 4 strands of antiparallel beta-sheet and contains the catalytic triad Cys-His-Asn
4. His-Me finger endonucleases (1)
   core: (alpha)-beta-omega_loop-beta-alpha; embeded in larger different structures
5. RNase A-like (1)
   contains long curved beta-sheet and 3 helices
6. Prion protein domain (1)
   beta-alpha-beta-alpha(2); antiparallel beta-ribbon
7. LysM domain (1)
   beta-alpha(2)-beta;
8. Urease, gamma-subunit (1)
   alpha(3)-beta(2); antiparallel hairpin
9. IL8-like (2)
   beta(3)-alpha
10. DNA-binding domain (1)
    beta(3)-alpha; 2 layers: alpha/beta
11. Penicillin-binding protein 2x (pbp-2x), c-terminal domain (1)
    alpha1-beta3; 2 layers: alpha/beta; order 132
12. Ribosomal proteins L23 and L15e (1)
    beta-(alpha)-beta-alpha-beta(2); 3 layers: alpha/beta/alpha; antiparallel beta-sheet: order 1243
13. HIT-like (1)
    alpha-beta3-alpha-beta2; 3 layers: alpha/beta/alpha
14. Ribosomal protein S5 domain 2-like (1)
    core: beta(3)-alpha-beta-alpha; 2 layers: alpha/beta; left-handed crossover
15. beta-Grasp (ubiquitin-like) (9)
    core: beta(2)-alpha-beta(2); mixed beta-sheet 2143
16. FAD-linked reductases, C-terminal domain (1)
    alpha+beta sandwich
17. Cystatin-like (5)
    Core: alpha-beta(4); helix packs against coiled antiparallel beta-sheet
18. Transcriptional coactivator PC4 C-terminal domain (1)
    beta(4)-alpha; forms dimers by swapping helices
19. MHC antigen-recognition domain (1)
    dimeric
20. Ubiquitin conjugating enzyme (1)
    alpha-beta(4)-alpha(3); core: meander beta-sheet plus one helix 2
21. Diaminopimelate epimerase (1)
    mixed beta-sheet folds into a barrel (n=8, S=14) around the central helix
22. Fluorescent proteins (1)
    beta-sheet folds into a barrel (n=11, S=14) around the central helix
23. Transcriptional factor tubby, C-terminal domain (1)
    beta-sheet folds into a barrel (n=12, S=12) around the central helix
24. Pilin (1)
    contains very long N-terminal helix, which end is packed against beta-sheet
25. Acidic mitochondrial matrix protein p32 (1)
    core: beta(7)-alpha(2); N- and C-terminal extensions form a coiled coil subdomain
26. FKBP-like (3)
    core: beta(2)-alpha-beta(2); antiparallel beta-sheet
27. Ribosomal protein S16 (1)
    beta(4)-alpha-beta; 2 layers: alpha/beta; mixed beta-sheet, order: 51234
28. Ribosomal protein S19 (1)
    alpha-beta-X-beta(2); 2 layers: alpha/beta; mixed beta-sheet, order: 123
29. Ribosomal protein L31e (1)
    beta-alpha-beta-(aplha)-beta(2); 2 layers: alpha/beta; mixed beta-sheet, order: 1342
30. Allophycocyanin linker chain (domain) (1)
    beta(2)-alpha-beta; 2 layers: alpha/beta
31. Cdc48 domain 2-like (1)
    beta-alpha-beta(3); 2 layers: alpha/beta
32. Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase (1)
    beta-alpha-beta(3); 2 layers: alpha/beta
33. Bacterial protein-export protein SecB (1)
    beta(4)-alpha(2); two layers: alpha/beta; antiparallel sheet: order 1432
34. DNA-binding domain of Mlu1-box binding protein MBP1 (1)
    beta(4)-alpha(2)-beta(2)-alpha; antiparallel sheet: order 123465
35. Heme-binding protein A (HasA) (1)
    beta-alpha-beta(6)-alpha(2); antiparallel sheet: order 165432
36. Chalcone isomerase (1)
    beta(3)-alpha(2)-beta-alpha(2)-beta3; 2 layers alpha/beta; antiparallel sheet: order 1234567
37. CBS-domain (1)
    core: beta-alpha-beta(4); 2 layers: alpha/beta
38. Thioesterase/thiol ester dehydrase-isomerase (1)
    core: beta-alpha-beta(4); 2 layers: alpha/beta
39. Dynein light chain 8 (DLC8) (1)
    core: beta-alpha(2)-beta-X-beta(2); 2 layers: alpha/beta; antiparallel beta-sheet: order 1342
40. CI-2 family of serine protease inhibitors (1)
    alpha+beta sandwich; loop across free side of beta-sheet
41. alpha/beta-Hammerhead (5)
    core: beta-BETA-alpha-beta-BETA-beta-alpha; contains a beta-hammerhead motif similar to that in barrel-sandwich hybrids
42. POZ domain (1)
    core: beta(2)-alpha(2)-beta(2)-alpha(2); 2 layers a/b; mixed sheet: 2143
43. Elongation factor Ts (EF-Ts), dimerisation domain (1)
    beta(2)-alpha(n)-beta; 2 layers a/b; antiparallel sheet: 123
44. Fe,Mn superoxide dismutase (SOD), C-terminal domain (1)
    alpha-beta(2)-alpha-beta-alpha(2); 3 strands of antiparallel sheet: 213
45. Ribosomal protein L7/12, C-terminal domain (1)
    beta-alpha(2)-beta-alpha-beta; 2 layers, alpha/beta
46. Transcription-state regulator AbrB, the N-terminal DNA recognition domain (1)
    beta-alpha-beta(2); 2 layers, alpha/beta; antiparallel beta-sheet: order 123
47. Ribosomal protein L11, N-terminal domain (1)
    beta-alpha(2)-beta(2); 2 layers, alpha/beta; antiparallel beta-sheet: order 123
48. Anti-LPS factor/recA domain (2)
    alpha-beta(3)-alpha(2); 2 layers, alpha/beta
49. Signal recognition particle alu RNA binding heterodimer, SRP9/14 (1)
    (beta)-alpha-beta(3)-alpha; 2 layers, alpha/beta
50. dsRBD-like (3)
    alpha-beta(3)-alpha; 2 layers: alpha/beta
51. KH-domain (1)
    beta-alpha(2)-beta(2)-alpha; 2 layers: alpha/beta
52. Alpha-lytic protease prodomain-like (3)
    core: alpha-beta(2)-(alpha)-beta; 2 layers: alpha/beta
53. Ribosomal protein S3 C-terminal domain (1)
    alpha(2)-beta(4); 2 layers: alpha/beta; antiparallel beta-sheet: order 2143
54. Enolase N-terminal domain-like (1)
    beta(3)-alpha(3); meander and up-and-down bundle
55. Ribosomal protein L22 (1)
    beta-alpha(3)-beta(2); 2 layers: alpha/beta; related to the enolase/MLE N-domain fold by a circular permutation
56. GroEL-like chaperone, intermediate domain (1)
    3-helical bundle packed against 3-stranded mixed beta-sheet
57. DNA damage-inducible protein DinI (1)
    beta-alpha-beta(2)-alpha; 2 layers: alpha/beta; mixed sheet 213; crossing loops
58. Ferredoxin-like (36)
    alpha+beta sandwich with antiparallel beta-sheet; (beta-alpha-beta)x2
59. Ribosomal protein L30p/L7e (1)
    core: beta-alpha-beta-alpha-beta; antiparallel beta-sheet: order 312; some similarity with the ferredoxin-like fold
60. Probable bacterial effector-binding domain (1)
    duplication of beta-alpha-beta(2) motif: antiparallel beta sheet forms barrel (n=6, S=12)
61. tRNA splicing product Appr>p cyclic nucleotide phosphodiesterase (1)
    duplication of beta-alpha-beta-alpha-beta motif: antiparallel beta sheet forms barrel (n=6, S=8) similar to the barrel of prokaryotic DNA topoisomerases I and III
62. Pepsin inhibitor-3 (1)
    duplication of beta(3)-alpha(2) motif: meander beta sheets form barrel-like structure
63. mRNA triphosphatase CET1 (1)
    duplication of beta-alpha-beta(3) motif: antiparallel beta sheet forms wide barrel (n=8, S=16) with a channel running through it
64. eIF1-like (1)
    beta(2)-alpha-beta(2)-alpha-beta; 2 layers: alpha/beta; mixed beta-sheet: order 51243
65. Hedgehog/DD-pepidase (1)
    alpha-beta(2)-alpha-beta(2); 2 layers: alpha/beta
66. Alpha-L RNA-binding motif (1)
    alpha(2)-beta(2)-loop-beta; 2 layers: alpha/beta
67. RRF/tRNA synthetase additional domain-like (3)
    core:alpha-beta(2)-alpha-beta(2); 2 layers: alpha/beta
68. IF3-like (2)
    beta-alpha-beta-alpha-beta(2); 2 layers; mixed sheet 1243, strand 4 is antiparallel to the rest
69. C-terminal domain of TolA (1)
    alpha-beta(2)-alpha-beta; 2 layers, alpha/beta; left-handed beta-alpha-beta unit
70. Yest killer toxins (1)
    beta-alpha-beta(2)-alpha-beta(2); 2 layers, alpha/beta; left-handed crossover connection
71. Cell division protein MinE topological specificity domain (1)
    dimer of alpha-beta(2) motifs ; 2 layers, alpha/beta
72. Cyanase C-terminal domain (1)
    intertwined dimer of alpha-beta(2) motifs ; 2 layers, alpha/beta
73. RuBisCO, small subunit (1)
    alpha-beta(2)-alpha-beta(2); 2 layers, alpha/beta
74. DCoH-like (4)
    beta(2)-alpha-beta(2)-alpha; 2 layers, alpha/beta
75. MutS N-terminal domain-like (2)
    beta(2)-alpha-beta(2)-alpha; 2 layers, alpha/beta
76. GYF domain (1)
    beta(2)-alpha-beta(2)-alpha; 2 layers, alpha/beta
77. Ribosomal protein L5 (1)
    beta-alpha-beta(2)-alpha-beta(3)-alpha; 2 layers, alpha/beta; antiparallel beta-sheet: order 231654
78. RPB5-like RNA polymerase subunit (1)
    core: beta-alpha-beta-alpha-beta(2); 2 layers, alpha/beta
79. Bacillus chorismate mutase-like (4)
    core: beta-alpha-beta-alpha-beta(2); mixed beta-sheet: order: 1423, strand 4 is antiparallel to the rest
80. Tautomerase/MIF (1)
    (beta-alpha-beta)2; 2 layers: alpha/beta; mixed beta-sheet
    forms trimers with three closely packed beta-sheets
81. Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain (1)
    core: alpha-beta-alpha-beta(3); mixed sheet: 2134, strand 2 is parallel to strand 1
82. N domain of copper amine oxidase-like (2)
    alpha-beta(5)-alpha; 2 layers: alpha/beta; meander antiparallel sheet
83. Bactericidal permeability-increasing protein, BPI (1)
    beta-alpha-beta(5)-alpha-beta2; 2 layers: alpha/beta; antiparallel sheet
84. Subtilisin inhibitor (1)
    alpha+beta sandwich
85. RNA bacteriophage capsid protein (1)
    6-standed beta-sheet followed with 2 helices; meander
86. Translation initiation factor eIF4e (1)
    beta(2)-alpha-beta(2)-alpha-beta(2)-alpha-beta-2; 2 layers: alpha/beta; antiparallel sheet: 21356478
87. CO dehydrogenase flavoprotein C-domain-like (2)
    core: beta(3,4)-alpha(3); alpha+beta sandwich
88. SRF-like (1)
    alpha-beta(2)-alpha; dimer; 3 layers a/b/a; antiparallel beta-sheet
89. The origin DNA-binding domain of SV40 T-antigen (1)
    alpha-beta-alpha-beta(2)-alpha-beta-alpha-beta; 3 layers:a/b/a; antiparallel sheet 41325
90. NADH oxidase/flavin reductase (1)
    core: (alpha-beta-alpha-beta)2; 3 layers a/b/a; antiparallel beta-sheet: 1243
91. N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1 (1)
    alpha-beta-alpha(2)-beta(3)-alpha; 3 layers a/b/a; antiparallel beta-sheet: 4123
92. Zincin-like (2)
    contains mixed beta sheet with connection over free side of the sheet
93. SH2-like (1)
    3 layers: a/b/a; antiparallel beta-sheet of 5 strands is flaked by two helices
94. Histidine-containing phosphocarrier proteins (HPr) (1)
    beta-alpha-beta(2)-alpha-beta-alpha; 2 layers: a/b; antiparallel sheet 1423
95. Homing endonuclease-like (2)
    alpha-beta(2)-alpha-beta(2)-alpha; 2 layers: a/b; antiparallel sheet 1243
96. T-fold (1)
    beta(2)-alpha(2)-beta(2); 2 layers: alpha/beta; antiparallel sheet 1234
    tunnel-shaped: its known members form wide oligomeric barrels different sizes
97. Cell cycle regulatory proteins (1)
    beta(2)-alpha(2)-beta(2); 2 layers: alpha/beta; antiparallel sheet 1243
    can form strand-exchange dimers
98. beta-lactamase-inhibitor protein, BLIP (1)
    alpha(2)-beta(4); 2 layers: alpha/beta
99. Ribosomal protein L9 C-domain (1)
    alpha-beta-alpha(2)-beta(2); 2 layers: alpha/beta
100. L9 N-domain-like (1)
     beta(2)-alpha-beta-alpha; 3 layers: alpha/beta/alpha
101. Polynucleotide phosporylase/guanosine pentaphospate synthase (PNPase/GPSI), domains 2 and 5 (1)
     beta(2)-alpha-beta(2)-alpha; 3 layers: alpha/beta/alpha; antiparallel sheet: order 2134
102. Regulatory factor Nef (1)
     alpha(2)-beta(4)-alpha; 3 layers: alpha/beta/alpha
103. Mosquitocidal delta-endotoxin CytB (1)
     core: beta-alpha(2)-beta-alpha(2)-beta(4); 3 layers: a/b/a
104. Class II aaRS and biotin synthetases (1)
     contains large mixed beta-sheet
105. Clathrin adaptor appendage domain (1)
     beta-alpha-beta-alpha-beta(4)-alpha; 3 layers: a/b/a; bifurcated antiparallel beta-sheet
106. Sterol carrier protein 2 (SCP2) (1)
     alpha-beta(3)-(crossover)-beta-(alpha)-beta; 3 layers: a/b/a; antiparallel beta-sheet of 5 strands; order: 32145
107. Ran-binding protein mog1p (1)
     (beta-hairpin)-beta(3)-alpha-beta(4)-alpha; 3 layers: a/b/a; antiparallel beta-sheet of 7 strands; order: 1237654
108. Acyl-CoA N-acyltransferases (Nat) (1)
     3 layers: a/b/a; contains mixed beta-sheet
109. Actin depolymerizing proteins (1)
     3 layers: a/b/a; contains mixed beta-sheet
110. Profilin-like (3)
     core: 2 alpha-helices and 5-stranded sheet; 3 layers: alpha/beta/alpha
111. PR-1-like (1)
     alpha-beta-alpha-beta-alpha(2)-beta(2); 3 layers, alpha/beta/alpha; mixed sheet: order 1342
112. IIA domain of mannitol-specific and ntr phosphotransherase EII (1)
     beta-alpha(2)-beta(3)-alpha(3); 3 layers, alpha/beta/alpha; mixed sheet: order 1342
113. Nucleoside triphosphate pyrophosphorylase (MutT) (1)
     beta(2)-alpha-beta(3)-alpha; 3 layers: alpha/beta/alpha; mixed sheet
     contains beta-grasp motif
114. 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain (1)
     core: alpha-beta(2)-alpha-beta(2)-alpha-beta; 3 layers; mixed sheet: order 31425
115. Hypothetica protein YrdC (1)
     core: alpha-beta(2)-alpha-beta-alpha(2)-beta(2)-alpha-beta-alpha-beta(3); 3 layers; mixed twisted sheet of 9 strands
116. Hypothetica protein HI1434 (YbaK homologue) (1)
     core: alpha-beta-alpha-beta(2)-(alpha-beta)2-alpha-beta(2)-alpha-beta; 3 layers; bifurcated mixed sheet
117. Thymidylate synthase/dCMP hydroxymethylase (1)
     contains large mixed beta-sheet
118. Bacteriophage T7 lysozyme (Zn amidase) (1)
     contains mixed beta-sheet
119. Streptomyces lysozyme (1)
     contains curved mixed beta-sheet; incomplete barrel
120. Cytochrome b5 (1)
     small, heme-binding fold
121. DNA topoisomerase I domain (1)
     beta(2)-alpha-beta-(alpha)-beta(2); left-handed crossover between strands 2 & 3
122. ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase (1)
     8-stranded mixed beta-sheet; 2 layers: alpha/beta
123. Sporulation responce regulatory protein Spo0B (1)
     core: alpha-beta-alpha-beta(2)-(alpha)-beta(2)
124. Ribonuclease Rh-like (1)
     alpha+beta fold
125. Ornithine decarboxylase C-terminal domain (1)
     complex alpha+beta motif
126. Pentein, beta/alpha-propeller (1)
     duplication: composed of 5 alpha-beta(2)-alpha-beta units arranged around pseudo fivefold axis
127. Creatinase/aminopeptidase (1)
     duplication: composed of two very similar alpha+beta folds
128. Glutamine synthase/guanidino kinase catalytic domain (1)
129. TBP-like (3)
     beta-alpha-beta(4)-alpha
130. S-adenosylmethionine synthetase (1)
     duplication: consists of 3 similar intertwined domains
     structural repeat: beta-alpha-beta(2)-alpha-beta; two layers, alpha/beta
131. DNA clamp (1)
     contains two helices and two beta sheets
     duplication: fold has internal pseudo two-fold symmetry
132. Mitochondrial processing peptidase, MPP (1)
     beta(2)-alpha(2)-beta(2)-alpha(5)-beta; 2 layers: a/b; mixed sheet: order 15243: strands 2 to 5 are connected with a ferredoxin-like topology
133. Molybdemum cofactor-binding domain (1)
     beta(2)-alpha-beta-alpha-beta; 2 layers: a/b; mixed sheet: order 1243: crossing loops
134. Sulfite reductase hemoprotein (SiRHP), domains 2 and 4 (1)
     beta-alpha-beta-alpha-beta(3)-alpha(2,3); mixed sheet: order 12345; left-handed crossover connection bettween strands 2 and 3
135. The spindle assembly checkpoint protein mad2 (1)
     beta-alpha(2)-beta(2)-alpha-beta(3); mixed sheet: order 132465
136. Phospholipase D/nuclease (1)
     beta-alpha-beta-alpha-beta-alpha-beta(4)-alpha; mixed sheet: order 1765234
137. Monooxygenase (hydroxylase) regulatory protein (1)
     corner-like structure formed by two sheets and filled in with 2-3 helices
138. B3/B4 domain of PheRS, PheT (1)
     3 layers: beta/beta/alpha sandwich
139. Aminoimidazole ribonucleotide synthetase (PurM) C-terminal domain (1)
     3 layers: alpha/beta/alpha; partial topological similarity to the ferredoxin-like fold
140. Ribosomal protein S8 (1)
     consists of 2 different alpha+beta subdomains arranged in a 4-layer structure: b/a/b/a
141. Ribosomal protein L6 (1)
     consists of two beta-sheets and one alpha-helix packed around single core
142. ATP-grasp (2)
     Consists of two subdomains with different alpha+beta folds
     shares functional and structural similarities with the PIPK and protein kinase superfamilies
143. SAICAR synthase-like (1)
     consists of two alpha+beta subdomains
144. Protein kinase-like (PK-like) (1)
     consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
145. FAD-binding domain (1)
     consists of two alpha+beta subdomains
146. Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain (1)
     consists of two alpha+beta subdomains
147. Methenyltetrahydromethanopterin cyclohydrolase (1)
     consists of two alpha+beta subdomains
148. Ubiquitin-protein ligase E3a, Hect catalytic domain (E6ap) (1)
     consists of two alpha+beta domains; the N-terminal domain is array of helices and beta-hairpins; the C-terminal domain is an a/b sandwich with one left-handed beta-alpha(n)-beta unit
149. Nitrile hydratase alpha chain (1)
     4 layers a/b/b/a; inside is a sandwich of two 2-stranded beta-sheets
150. 4'-Phosphopantetheinyl transferase SFP (1)
     4 layers a/b/b/a; duplication of beta-alpha(3)-beta(2) motif
151. DNase I-like (1)
     contains beta-sandwich; duplication of alpha+beta motif
152. Aldehyde ferredoxin oxidoreductase, N-terminal domain (1)
     contains sandwich; duplication of alpha+beta motif with single mixed sheet
     motif: beta(2)-alpha-beta(3)-alpha-beta; strand order 216345, strands 1 and 6 are parallel
153. N-terminal nucleophile aminohydrolases (Ntn hydrolases) (1)
     4 layers: alpha/beta/beta/alpha; has an unusual sheet-to-sheet packing
154. L-aminopeptidase D-Ala-esterase/amidase (1)
     duplication of beta(3)-alpha-beta-alpha motif; 4 layers: alpha/beta/beta/alpha
155. Histidine decarboxylase (1)
     contains "silk" beta-sandwich flanked on both sides with alpha-helices
156. S-adenosylmethionine decarboxylase (1)
     duplication of beta-alpha-beta(4)-alpha-beta-alpha-beta(2) motif; 4 layers a/b/b/a; antiparallel beta-sheets: order 23451687
157. Metallo-hydrolase/oxidoreductase (1)
     duplication of beta(4)-alpha-beta-alpha motif; 4 layers a/b/b/a; mixed beta-sheets
158. Protein serine/threonine phosphatase 2C (1)
     4 layers: alpha/beta/beta/alpha; antiparallel beta sheets
159. Metallo-dependent phosphatases (1)
     4 layers: alpha/beta/beta/alpha; mixed beta sheets; contains duplication
160. Nitrilase/N-carbamyl-D-aminoacid amidohydrolase (1)
     4 layers: alpha/beta/beta/alpha; mixed beta sheets; contains duplication
161. Anthranilate synthase aminodeoxyisochorismate synthase/lyase subunit TrpE (1)
     duplication: contains four repeats of alpha-beta(2)-beta motif arranged in a 4 layer core structure: alpha/beta/beta/alpha; orthogonally packed beta-sheets
162. Lactate & malate dehydrogenases, C-terminal domain (1)
     unusual fold, defines family
163. DNA breaking-rejoining enzymes (1)
     core: alpha3-beta3-alpha4; one side of beta-sheet is exposed
164. SMAD MH1 domain (1)
     consists of four alpha-helices and three beta-ribbons
165. Ribosome inactivating proteins (RIP) (1)
     contains mixed beta-sheet
166. ADP-ribosylation (1)
     unusual fold
167. Peptide deformylase (1)
     alpha-beta(5)-alpha; 3 layers: a/b/a; meander beta-sheet wraps around the C-terminal alpha-helix
168. Succinate dehydrogenase/fumarate reductase catalytic domain (1)
     unusual fold
169. C-type lectin-like (1)
     unusual fold
170. SRCR-like (2)
     unusual fold; disulphide-rich; core: beta-x-alpha-beta-loop-beta
171. Fibrinogen C-terminal domains (1)
     unusual fold
172. gp120 core (1)
     unusual fold
173. Methionine synthase (activation domain) (1)
     unusual fold
174. Nitric oxide (NO) synthase oxygenase domain (1)
     unusual fold
175. Penicillin-binding protein 2x (pbp-2x), N-terminal domain (1)
     unusual fold
176. Sulfite oxidase, middle catalytic domain (1)
     unusual fold; contains 3 layers of beta-sheet structure and a beta-grasp like motif
177. Fumarylacetoacetate hydrolase, FAH (1)
     unusual fold; contains 3 layers of beta-sheet structure and a SH3-like like motif
178. Aromatic aminoacid monoxygenases, catalytic and oligomerization domains (1)
     unusual fold
179. Substrate-binding domain of HMG-CoA reductase (1)
     unusual fold
180. Conserved core of transcriptional regulatory protein vp16 (1)
     unusual fold
181. Insert subdomain of RNA polymerase alpha subunit N-terminal domain (1)
     unusual fold; contains a left-handed beta-alpha-beta unit
182. Baseplate structural protein gp11 (1)
     unusual fold; trimer
183. Major capsid protein gp5 (1)
     unusual fold
184. Non-globular alpha_beta subunits of globular proteins (1)