Fold: Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase

beta-alpha-beta(3); 2 layers: alpha/beta

Lineage:

1. Root: scop
2. Class: Alpha and beta proteins (a+b)
   Mainly antiparallel beta sheets (segregated alpha and beta regions)
3. Fold: Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase
   beta-alpha-beta(3); 2 layers: alpha/beta

Superfamilies:

1. Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase (3)
   1. Glyoxalase I (lactoylglutathione lyase) (2)
      duplication: consists of two clear structural repeats each having this fold
   2. Bleomycin resistance protein, BRP (2)
      duplication: consists of two clear structural repeats each having this fold
      subunit fold and dimeric assembly are similar to those of glyoxalase
   3. Extradiol dioxygenases (4)
      duplication: consists of 2 similar domains with 2 repeats in each
      Similar to the glyoxalase dimer but the repeats are swapped between domains