Fold: Cysteine proteinases

consists of one alpha-helix and 4 strands of antiparallel beta-sheet and contains the catalytic triad Cys-His-Asn

Lineage:

1. Root: scop
2. Class: Alpha and beta proteins (a+b)
   Mainly antiparallel beta sheets (segregated alpha and beta regions)
3. Fold: Cysteine proteinases
   consists of one alpha-helix and 4 strands of antiparallel beta-sheet and contains the catalytic triad Cys-His-Asn

Superfamilies:

1. Cysteine proteinases (7)
   the constitute families differ by insertion into and circular permutation of the common catalytic core made of one alpha-helix and 3-strands of beta-sheet
   1. Papain-like (19)
   2. FMDV leader protease (1)
   3. Calpain large subunit, catalytic domain (domain II) (2)
   4. Transglutaminase (1)
   5. Arylamine N-acetyltransferase (1)
      fold similar to that of the factor XIII catalytic domain
   6. Deubiquitinating enzyme (2)
   7. Adenoviral protease-like (2)