Fold: Lactate & malate dehydrogenases, C-terminal domain

unusual fold, defines family

Lineage:

1. Root: scop
2. Class: Alpha and beta proteins (a+b)
   Mainly antiparallel beta sheets (segregated alpha and beta regions)
3. Fold: Lactate & malate dehydrogenases, C-terminal domain
   unusual fold, defines family

Superfamilies:

1. Lactate & malate dehydrogenases, C-terminal domain (1)
   1. Lactate & malate dehydrogenases, C-terminal domain (16)
      N-terminal domain is NAD-binding module (alpha/beta Rossmann-fold domain)
      1. Malate dehydrogenase
         1. Pig (Sus scrofa) (3)
         2. Sorghum (Sorghum vulgare), chloroplast (1)
         3. Flaveria bidentis, chloroplast (1)
         4. Escherichia coli (2)
         5. Thermus flavus (2)
         6. Haloarcula marismortui (3)
         7. Aquaspirillum arcticum (3)
      2. L-2-hydroxyisocapronate dehydrogenase, L-HICDH
         1. Lactobacillus confusus (1)
      3. Lactate dehydrogenase
         1. Pig (Sus scrofa) (3)
         2. Mouse (Mus musculus) (1)
         3. Dogfish (Squalus acanthias) (3)
         4. Malaria parasite (Plasmodium falciparum) (3)
         5. Bacillus stearothermophilus (3)
         6. Lactobacillus casei (1)
         7. Bifidobacterium longum, strain am101-2 (2)
         8. Thermotoga maritima (1)