Fold: HIT-like

alpha-beta3-alpha-beta2; 3 layers: alpha/beta/alpha

Lineage:

1. Root: scop
2. Class: Alpha and beta proteins (a+b)
   Mainly antiparallel beta sheets (segregated alpha and beta regions)
3. Fold: HIT-like
   alpha-beta3-alpha-beta2; 3 layers: alpha/beta/alpha

Superfamilies:

1. HIT-like (2)
   1. HIT (HINT, histidine triad) family of protein kinase-interacting proteins (4)
      topologically similar to the N-terminal domain of protein kinases
   2. Hexose-1-phosphate uridylyltransferase (1)
      duplication: consists of 2 HIT-like motifs
      binds zinc and iron ions