Fold: Thymidylate synthase/dCMP hydroxymethylase

contains large mixed beta-sheet

Lineage:

1. Root: scop
2. Class: Alpha and beta proteins (a+b)
   Mainly antiparallel beta sheets (segregated alpha and beta regions)
3. Fold: Thymidylate synthase/dCMP hydroxymethylase
   contains large mixed beta-sheet

Superfamilies:

1. Thymidylate synthase/dCMP hydroxymethylase (1)
   1. Thymidylate synthase/dCMP hydroxymethylase (9)
      1. Thymidylate synthase
         1. Escherichia coli (39)
         2. Lactobacillus casei (39)
         3. Bacillus subtilis (5)
         4. Bacteriophage T4 (1)
         5. Pneumocystis carinii (1)
         6. Rat (Rattus norvegicus) (2)
         7. Human (Homo sapiens) (3)
      2. Bifunctional enzyme dihidrofolate reductase-thymidylate synthase, TS domain
         1. Leishmania major (1)
      3. dCMP hydroxymethylase
         1. Bacteriophage T4 (3)