Fold: Profilin-like

core: 2 alpha-helices and 5-stranded sheet; 3 layers: alpha/beta/alpha

Lineage:

1. Root: scop
2. Class: Alpha and beta proteins (a+b)
   Mainly antiparallel beta sheets (segregated alpha and beta regions)
3. Fold: Profilin-like
   core: 2 alpha-helices and 5-stranded sheet; 3 layers: alpha/beta/alpha

Superfamilies:

1. Profilin (actin-binding protein) (1)
   alpha-beta(2)-alpha-beta(5)-alpha
2. GAF domain (1)
   alpha(2)-beta(2)-alpha-beta(3)-alpha
3. PYP-like sensor domain (3)
   alpha-beta(2)-alpha(2)-beta(3)