Fold: SIS domain

consists of two similar domains related by pseudodyad; duplication
3 layers: a/b/a; parallel beta-sheet of 5 strands, order 21345

Lineage:

1. Root: scop
2. Class: Alpha and beta proteins (a/b)
   Mainly parallel beta sheets (beta-alpha-beta units)
3. Fold: SIS domain
   consists of two similar domains related by pseudodyad; duplication
   3 layers: a/b/a; parallel beta-sheet of 5 strands, order 21345

Superfamilies:

1. SIS domain (2)
   1. "Isomerase domain" of glucosamine 6-phosphate synthase (GLMS) (1)
   2. Phosphoglucose isomerase, PGI (2)
      permutation of the superfamily fold