Fold: Dihydrofolate reductases

3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest

Lineage:

1. Root: scop
2. Class: Alpha and beta proteins (a/b)
   Mainly parallel beta sheets (beta-alpha-beta units)
3. Fold: Dihydrofolate reductases
   3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest

Superfamilies:

1. Dihydrofolate reductases (1)
   1. Dihydrofolate reductases (10)
      1. Dihydrofolate reductase, prokaryotic type
         1. Escherichia coli (42)
         2. Lactobacillus casei (5)
         3. Mycobacterium tuberculosis (4)
         4. Thermotoga maritima (2)
         5. Haloferax volcanii (1)
      2. Dihydrofolate reductases, eukaryotic type
         1. Chicken (Gallus gallus) (8)
         2. Human (Homo sapiens) (11)
         3. Fungus (Pneumocystis carinii) (7)
         4. Yeast (Candida albicans) (2)
      3. Bifunctional enzyme dihidrofolate reductase-thymidylate synthase, DFR domain
         1. Leishmania major (1)