Fold: alpha/beta-Hydrolases

core: 3 layers, a/b/a; mixed beta-sheet of 8 strands, order 12435678, strand 2 is antiparallel to the rest

Lineage:

1. Root: scop
2. Class: Alpha and beta proteins (a/b)
   Mainly parallel beta sheets (beta-alpha-beta units)
3. Fold: alpha/beta-Hydrolases
   core: 3 layers, a/b/a; mixed beta-sheet of 8 strands, order 12435678, strand 2 is antiparallel to the rest

Superfamilies:

1. alpha/beta-Hydrolases (20)
   many members have left-handed crossover connection between strand 8 and additional strand 9
   1. Acetylcholinesterase-like (8)
   2. Carboxylesterase (2)
   3. Mycobacterial antigens (2)
   4. Prolyl oligopeptidase, C-terminal domain (1)
   5. Serine carboxypeptidase (4)
   6. Gastric lipase (1)
   7. Proline iminopeptidase (2)
   8. Haloalkane dehalogenase (3)
   9. Dienelactone hydrolase (2)
   10. Carbon-carbon bond hydrolase (1)
   11. Epoxide hydrolase (3)
   12. Haloperoxidase (5)
   13. Thioesterases (2)
   14. Carboxylesterase/thioesterase 1 (2)
   15. A novel bacterial esterase (1)
   16. Lipase (1)
   17. Fungal lipases (9)
   18. Bacterial lipase (5)
   19. Pancreatic lipase, N-terminal domain (6)
   20. Hydroxynitrile lyase (2)