Fold: Phosphorylase/hydrolase-like

core: 3 layers, a/b/a ; mixed sheet of 5 strands: order 21354; strand 4 is antiparallel to the rest; contains crossover loops

Lineage:

1. Root: scop
2. Class: Alpha and beta proteins (a/b)
   Mainly parallel beta sheets (beta-alpha-beta units)
3. Fold: Phosphorylase/hydrolase-like
   core: 3 layers, a/b/a ; mixed sheet of 5 strands: order 21354; strand 4 is antiparallel to the rest; contains crossover loops

Superfamilies:

1. Hydrogenase maturating endopeptidase HybD (1)
   the fold coincides with the consensus core structure
2. Purine and uridine phosphorylases (1)
   complex architecture; contains mixed beta-sheet of 8 strands, order 23415867, strands 3, 6 & 7 are antiparallel to the rest; and barrel, closed; n=5, S=8
3. Peptidyl-tRNA hydrolase (1)
4. Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase) (1)
5. Zn-dependent exopeptidases (5)
   core: mixed beta-sheet of 8 strands, order 12435867; strands 2, 6 & 7 are antiparallel to the rest
6. LigB subunit of an aromatic-ring-opening dioxygenase LigAB (1)
   circular permutation of the common fold, most similar to the PNP fold