Superfamily: Restriction endonuclease-like

Lineage:

1. Root: scop
2. Class: Alpha and beta proteins (a/b)
   Mainly parallel beta sheets (beta-alpha-beta units)
3. Fold: Restriction endonuclease-like
   core: 3 layers, a/b/a; mixed beta-sheet of 5 strands, order 12345; strands 2 &, in some families, 5 are antiparallel to the rest
4. Superfamily: Restriction endonuclease-like

Families:

1. Restriction endonuclease EcoRI (1)
2. Restriction endonuclease EcoRV (1)
3. Restriction endonuclease BamHI (1)
4. Restriction endonuclease BglI (1)
5. Restriction endonuclease BglII (1)
6. Restriction endonuclease PvuII (1)
7. Restriction endonuclease Cfr10I (1)
8. Restriction endonuclease MunI (1)
9. Restriction endonuclease NaeI (1)
10. Restriction endonuclease NgoIV (1)
11. Restriction endonuclease BsobI (1)
12. Restriction endonuclease FokI, C-terminal (catalytic) domain (1)
13. lambda exonuclease (1)
14. DNA mismatch repair protein MutH from (1)
15. Very short patch repair (VSR) endonuclease (1)
16. TnsA endonuclease, N-terminal domain (1)
17. Holliday junction resolvase (Endonuclease I) (1)