Superfamily: (Phosphotyrosine protein) phosphatases II

share with the family I the common active site structure with a circularly permuted topology

Lineage:

1. Root: scop
2. Class: Alpha and beta proteins (a/b)
   Mainly parallel beta sheets (beta-alpha-beta units)
3. Fold: (Phosphotyrosine protein) phosphatases II
   core: 3 layers, a/b/a; parallel beta-sheet of 4 strands, order 1432
4. Superfamily: (Phosphotyrosine protein) phosphatases II
   share with the family I the common active site structure with a circularly permuted topology

Families:

1. Dual-specificity phosphatases (2)
2. Higher-molecular-weight phosphotyrosine protein phosphatases (8)
   have an extension to the beta-sheet of 3 antiparallel strands before strand 4
3. Phoshphoinositide phosphatase Pten (Pten tumor suppressor), N-terminal domain (1)