Family: Higher-molecular-weight phosphotyrosine protein phosphatases

have an extension to the beta-sheet of 3 antiparallel strands before strand 4

Lineage:

1. Root: scop
2. Class: Alpha and beta proteins (a/b)
   Mainly parallel beta sheets (beta-alpha-beta units)
3. Fold: (Phosphotyrosine protein) phosphatases II
   core: 3 layers, a/b/a; parallel beta-sheet of 4 strands, order 1432
4. Superfamily: (Phosphotyrosine protein) phosphatases II
   share with the family I the common active site structure with a circularly permuted topology
5. Family: Higher-molecular-weight phosphotyrosine protein phosphatases
   have an extension to the beta-sheet of 3 antiparallel strands before strand 4

Protein Domains:

1. Tyrosine phosphatase
   1. Human (Homo sapiens), 1B (24)
   2. Human (Homo sapiens), mu (1)
      receptor protein tyrosine phosphatase mu, domain 1
   3. Mouse (Mus musculus) (1)
      receptor protein tyrosine phosphatase alpha, domain 1
   4. Human (Homo sapiens), shp-2 (1)
   5. Human (Homo sapiens), shp-1 (1)
   6. Yersinia enterocolitica (4)
2. SptP tyrosine phosphatase, catalytic domain
   1. Salmonella typhimurium (2)
3. RPTP Lar
   duplication: tandem repeat of the phosphatase domain
   1. Human (Homo sapiens) (1)