Fold: (Phosphotyrosine protein) phosphatases II

core: 3 layers, a/b/a; parallel beta-sheet of 4 strands, order 1432

Lineage:

1. Root: scop
2. Class: Alpha and beta proteins (a/b)
   Mainly parallel beta sheets (beta-alpha-beta units)
3. Fold: (Phosphotyrosine protein) phosphatases II
   core: 3 layers, a/b/a; parallel beta-sheet of 4 strands, order 1432

Superfamilies:

1. (Phosphotyrosine protein) phosphatases II (3)
   share with the family I the common active site structure with a circularly permuted topology
   1. Dual-specificity phosphatases (2)
      1. VH1-related dual-specificity phosphatase, VHR
         1. Human (Homo sapiens) (2)
      2. Mapk phosphotase Pyst1 (mkp3)
         1. Human (Homo sapiens) (1)
   2. Higher-molecular-weight phosphotyrosine protein phosphatases (8)
      have an extension to the beta-sheet of 3 antiparallel strands before strand 4
      1. Tyrosine phosphatase
         1. Human (Homo sapiens), 1B (24)
         2. Human (Homo sapiens), mu (1)
            receptor protein tyrosine phosphatase mu, domain 1
         3. Mouse (Mus musculus) (1)
            receptor protein tyrosine phosphatase alpha, domain 1
         4. Human (Homo sapiens), shp-2 (1)
         5. Human (Homo sapiens), shp-1 (1)
         6. Yersinia enterocolitica (4)
      2. SptP tyrosine phosphatase, catalytic domain
         1. Salmonella typhimurium (2)
      3. RPTP Lar
         duplication: tandem repeat of the phosphatase domain
         1. Human (Homo sapiens) (1)
   3. Phoshphoinositide phosphatase Pten (Pten tumor suppressor), N-terminal domain (1)
      1. Phoshphoinositide phosphatase Pten (Pten tumor suppressor), N-terminal domain
         1. Human (Homo sapiens) (1)