Fold: DHS-like NAD/FAD-binding domain

3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456; Rossmann-like

Lineage:

1. Root: scop
2. Class: Alpha and beta proteins (a/b)
   Mainly parallel beta sheets (beta-alpha-beta units)
3. Fold: DHS-like NAD/FAD-binding domain
   3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456; Rossmann-like

Superfamilies:

1. DHS-like NAD/FAD-binding domain (4)
   binds cofactor molecules in the opposite direction than classical Rossman fold
   1. Deoxyhypusine synthase, DHS (1)
   2. C-terminal domain of the electron transfer flavoprotein alpha subunit (2)
      lacks strand 3; shares the FAD-binding mode with the pyruvate oxidase domain
   3. Pyruvate oxidase and decarboxylase, middle domain (5)
      N-terminal domain is Pyr module, and C-terminal domain is PP module of thiamin diphosphate-binding fold
   4. Transhydrogenase domain III (dIII) (3)
      binds NADP, shares with the pyruvate oxidase FAD-binding domain a common ADP-binding mode