Fold: FAD/NAD(P)-binding domain

core: 3 layers, b/b/a; central parallel beta-sheet of 5 strands, order 32145; top antiparallel beta-sheet of 3 strands, meander

Lineage:

1. Root: scop
2. Class: Alpha and beta proteins (a/b)
   Mainly parallel beta sheets (beta-alpha-beta units)
3. Fold: FAD/NAD(P)-binding domain
   core: 3 layers, b/b/a; central parallel beta-sheet of 5 strands, order 32145; top antiparallel beta-sheet of 3 strands, meander

Superfamilies:

1. FAD/NAD(P)-binding domain (5)
   1. C-terminal domain of adrenodoxin reductase-like (3)
   2. FAD-linked reductases, N-terminal domain (10)
      C-terminal domain is alpha+beta is common for the family
   3. Guanine nucleotide dissosiation inhibitor, GDI (1)
      Similar to FAD-linked reductases in both domains but does not bind FAD
   4. Succinate dehydrogenase/fumarate reductase N-terminal domain (5)
   5. FAD/NAD-linked reductases, N-terminal and central domains (17)
      duplication: both domains have similar folds and functions
      most members of the family contain common C-terminal alpha+beta domain