Fold: NAD(P)-binding Rossmann-fold domains

core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
The nucleotide-binding modes of this and the next two folds/superfamilies are similar

Lineage:

1. Root: scop
2. Class: Alpha and beta proteins (a/b)
   Mainly parallel beta sheets (beta-alpha-beta units)
3. Fold: NAD(P)-binding Rossmann-fold domains
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

Superfamilies:

1. NAD(P)-binding Rossmann-fold domains (8)
   1. Alcohol/glucose dehydrogenases, C-terminal domain (9)
      N-terminal all-beta domain defines family
   2. Tyrosine-dependent oxidoreductases (27)
      also known as short-chain dehydrogenases and SDR family
      parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7
   3. Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain (20)
      family members also share a common alpha+beta fold in C-terminal domain
   4. Formate/glycerate dehydrogenases, NAD-domain (9)
      this domain interrupts the other domain which defines family
   5. Lactate & malate dehydrogenases, N-terminal domain (16)
   6. 6-phosphogluconate dehydrogenase-like, N-terminal domain (8)
      the beta-sheet is extended to 8 strands, order 32145678; strands 7 & 8 are antiparallel to the rest
      C-terminal domains also show some similarity
   7. Amino-acid dehydrogenase-like, C-terminal domain (11)
   8. Succinyl-CoA synthetase, alpha-chain, N-terminal (CoA-binding) domain (2)