Fold: Concanavalin A-like lectins/glucanases

sandwich; 12-14 strands in 2 sheets; complex topology

Lineage:

1. Root: scop
2. Class: All beta proteins
3. Fold: Concanavalin A-like lectins/glucanases
   sandwich; 12-14 strands in 2 sheets; complex topology

Superfamilies:

1. Concanavalin A-like lectins/glucanases (11)
   1. Legume lectins (20)
      1. Concanavalin A
         natural circle permutation: the "old" N- and C-termini are linked with a peptide bond,whereas the "new" ones correspond to a cleaved loop
         1. Jack bean (Canavalia ensiformis) (38)
         2. Brazilian jackbean (Canavalia brasiliensis) (1)
      2. Lectin
         1. Garden pea (Pisum sativum) (4)
            two-chain protein resulted from a single-chain precursor
         2. Common lentil (Lens culinaris) (4)
            two-chain protein resulted from a single-chain precursor
         3. West-central african legume (Griffonia simplicifolia) (3)
         4. Coral tree (Erythrina corallodendron) (7)
         5. Winged bean (Psophocarpus tetragonolobus) (2)
         6. Lathyrus ochrus, isolectin I (7)
         7. Lathyrus ochrus, isolectin II (2)
         8. Peanut (Arachis hypogaea) (5)
         9. Soybean (Glycine max) (4)
         10. Field bean (Dolichos lab lab), Fril (1)
             a legume lectin that delays hematopoietic progenitor maturation
         11. Horse gram (Dolichos biflorus), different isoforms (5)
         12. Mucana (Dioclea grandiflora) (1)
         13. Furze (Ulex europaeus), UEA-I (1)
         14. Furze (Ulex europaeus), UEA-II (5)
         15. Maackia amurensis, leukoagglutinin (1)
      3. Phytohemagglutinin-L, PHA-L, also arcelin
         single-chain subunit has "generic" topology
         1. Kidney bean (Phaseolus vulgaris) (4)
         2. Kidney bean (Phaseolus vulgaris), G02771, arcelin-5a (1)
      4. alpha-mylase inhibitor
         1. Kidney bean (Phaseolus vulgaris) (1)
   2. beta-Glucanase-like (4)
      1. Bacillus 1-3,1-4-beta-glucanase
         1. Bacillus licheniformis (1)
         2. Hybrid protein: residues 1-16 from Bacillus amyloliquefaciens and Bacillus macerans (3)
         3. Bacillus macerans (6)
      2. kappa-Carrageenase, catalytic
         1,3-alpha-1,4-beta-D-galactose-4-sulfate-3,6-anhydro-D-galactose 4 galactohydrolase
         1. Pseudoalteromonas carrageenovora (1)
   3. Galectin (animal S-lectin) (7)
      1. S-lectin, different isoforms
         1. Cow (Bos taurus) (4)
         2. Human (Homo sapiens) (6)
         3. Chicken (Gallus gallus) (1)
         4. Toad (Bufo arenarum) (2)
      2. Charcot-Leyden crystal (CLC) protein
         1. Human (Homo sapiens) (2)
      3. Galectin-3 CRD
         1. Human (Homo sapiens) (1)
      4. Congerin I
         1. Conger eel (Conger myriaster) (2)
   4. Laminin G-like module (3)
      1. Sex hormone-binding globulin
         1. Human (Homo sapiens) (2)
      2. Laminin alpha2 chain
         1. Mouse (Mus musculus) (2)
      3. Ligand-binding domain of neurexin 1beta
         1. Rat (Rattus norvegicus) (1)
   5. Pentraxin (pentaxin) (2)
      1. Serum amyloid P component (SAP)
         1. Human (Homo sapiens) (2)
      2. C-reactive protein (CRP)
         1. Human (Homo sapiens) (2)
   6. Clostridium neurotoxins, the second last domain (3)
      1. Tetanus neurotoxin
         1. Clostridium tetani (6)
      2. Botulinum neurotoxin
         1. Clostridium botulinum, serotype A (1)
         2. Clostridium botulinum, serotype B (2)
   7. Exotoxin A, N-terminal domain (1)
      1. Exotoxin A, N-terminal domain
         1. Pseudomonas aeruginosa (1)
   8. Vibrio cholerae sialidase, N-terminal and insertion domains (1)
      1. Vibrio cholerae sialidase, N-terminal and insertion domains
         both domains have this fold
         rest of protein is beta-propeller of six sheets
         1. Vibrio cholerae (1)
   9. Leech intramolecular trans-sialidase, N-terminal domain (1)
      1. Leech intramolecular trans-sialidase, N-terminal domain
         1. North american leech (Macrobdella decora) (5)
   10. Endoglucanase/cellulase I catalitic core (4)
       contains many insertions in the common fold
       1. Cellobiohydrolase I (cellulase)
          1. Trichoderma reesei (8)
       2. Endoglucanase I
          1. Trichoderma reesei (1)
          2. Fusarium oxysporum (4)
          3. Humicola insolens, cel7b (3)
   11. Xylanase/endoglucanase 12 (12)
       1. Xylanase II
          Partial overlap with common fold and the active sites of the other endoglucanases
          1. Bacillus circulans (7)
          2. Bacillus subtilis (1)
          3. Bacillus agaradhaerens (2)
          4. Trichoderma harzianum (1)
          5. Trichoderma reesei, xynI (1)
          6. Trichoderma reesei, xynII (6)
          7. Thermomyces lanuginosus (1)
          8. Aspergillus niger (1)
          9. Aspergillus kawachii (1)
          10. Paecilomyces variotii bainier (1)
          11. Dictyoglomus thermophilum (1)
       2. Endo-1,4-beta-glucanase (cellulase) CelB2 catalytic domain
          1. Streptomyces lividans (2)