Fold: DEATH domain

6 helices: closed bundle; greek-key; internal pseudo twofold symmetry

Lineage:

1. Root: scop
2. Class: All alpha proteins
3. Fold: DEATH domain
   6 helices: closed bundle; greek-key; internal pseudo twofold symmetry

Superfamilies:

1. DEATH domain (1)
   1. DEATH domain (10)
      Caspase recruitment domain, CARD
      1. p75 low affinity neurotrophin receptor
         residues 334-418
         1. Rat (Rattus norvegicus) (1)
      2. Fas
         1. Human (Homo sapiens) (1)
      3. FADD (Mort1)
         duplication: tandem repeat of CARD
         1. Human (Homo sapiens) (4)
         2. Mouse (Mus musculus) (1)
      4. Raidd CARD domain
         1. Human (Homo sapiens) (1)
      5. Apoptotic protease activating factor 1, APAF-1
         1. Human (Homo sapiens) (5)
      6. Procaspase 9 prodomain
         1. Human (Homo sapiens) (1)
      7. Iceberg
         an inhibitor of interleukin-1beta generation
         1. Human (Homo sapiens) (1)
      8. Pelle death domain
         1. Drosophila melanogaster (1)
      9. Tube death domain
         1. Drosophila melanogaster (1)