Fold: SAM domain-like

4-5 helices; bundle of two orthogonally packed alpha-hairpins; involved in the interactions with DNA and proteins

Lineage:

1. Root: scop
2. Class: All alpha proteins
3. Fold: SAM domain-like
   4-5 helices; bundle of two orthogonally packed alpha-hairpins; involved in the interactions with DNA and proteins

Superfamilies:

1. SAM/Pointed domain (2)
2. RuvA domain 2-like (2)
   duplication: contains two helix-hairpin-helix (HhH) motifs
3. C-terminal domain of RNA polymerase alpha subunit (1)
   contains one classic and one pseudo HhH motifs
4. DNA repair protein Rad51, N-terminal domain (1)
   contains one classic and one pseudo HhH motifs
5. Barrier-to-autointegration factor, BAF (1)
   contains one classic and one pseudo HhH motifs
6. DNA polymerase beta, N-terminal (8 kD)-domain (1)
   contains one classic and one pseudo HhH motifs
7. 5' to 3' exonuclease, C-terminal subdomain (1)
8. HRDC domain from RecQ helicase (1)
9. lambda integrase-like, N-terminal domain (1)
10. Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain (1)