Superfamily: EF-hand

Duplication: consists of two EF-hand units: each is made of two helices connected with calcium-binding loop

Lineage:

1. Root: scop
2. Class: All alpha proteins
3. Fold: EF Hand-like
   core: 4 helices; array of 2 hairpins, opened
4. Superfamily: EF-hand
   Duplication: consists of two EF-hand units: each is made of two helices connected with calcium-binding loop

Families:

1. Calbindin D9K (2)
   made of two EF-hands only
2. S100 proteins (9)
   dimer: subunits are made of two EF-hands
3. Osteonectin (1)
   5 helices; two EF-hands plus one of additional helices in the N-terminal part
4. Parvalbumin (7)
   6-helices; array of 3 hairpins, closed
   made with two-helical hairpin and two EF-hands
5. Calmodulin-like (27)
   Duplication: made with two pairs of EF-hands
6. Eps15 homology domain (EH domain) (2)
7. EF-hand modules in multidomain proteins (10)