Family: EF-hand modules in multidomain proteins

Lineage:

1. Root: scop
2. Class: All alpha proteins
3. Fold: EF Hand-like
   core: 4 helices; array of 2 hairpins, opened
4. Superfamily: EF-hand
   Duplication: consists of two EF-hand units: each is made of two helices connected with calcium-binding loop
5. Family: EF-hand modules in multidomain proteins

Protein Domains:

1. Phosphoinositide-specific phospholipase C, isozyme D1 (PLC-D!)
   1. Rat (Rattus norvegicus) (10)
2. Grancalcin
   Calpain small subunit homologue
   1. Human (Homo sapiens) (2)
3. Calpain small (regulatory) subunit (domain VI)
   1. Human (Homo sapiens) (1)
   2. Rat (Rattus norvegicus) (3)
   3. Pig (Sus scrofa) (2)
4. Calpain large subunit, C-terminal domain (domain IV)
   1. Human (Homo sapiens) (1)
   2. Rat (Rattus norvegicus) (1)
5. Dystrophin
   probably lost calcium-binding function; contains extra helices in each domain
   1. Human (Homo sapiens) (2)
6. Cbl
   1. Human (Homo sapiens) (3)
7. alpha-Spectrin
   1. Chicken (Gallus gallus) (1)