Family: Calmodulin-like

Duplication: made with two pairs of EF-hands

Lineage:

1. Root: scop
2. Class: All alpha proteins
3. Fold: EF Hand-like
   core: 4 helices; array of 2 hairpins, opened
4. Superfamily: EF-hand
   Duplication: consists of two EF-hand units: each is made of two helices connected with calcium-binding loop
5. Family: Calmodulin-like
   Duplication: made with two pairs of EF-hands

Protein Domains:

1. Troponin C
   1. Chicken (Gallus gallus) (21)
   2. Turkey (Meleagris gallopavo) (2)
   3. Rabbit (Oryctolagus cuniculus) (4)
   4. Chicken (Gallus gallus), cardiac isoform (1)
   5. Human (Homo sapiens), cardiac isoform (3)
2. Sarcoplasmic calcium-binding protein
   1. Sandworm (Nereis diversicolor) (1)
   2. Amphioxus (Branchiostoma lanceolatum) (1)
3. Aequorin
   structurally most similar to sarcoplasmic calcium-binding protein
   1. Jellyfish (Aequorea aequorea) (1)
4. Calcium vector protein
   1. Amphioxus (Branchiostoma lanceolatum) (2)
5. Calmodulin
   1. Human (Homo sapiens) (2)
   2. Cow (Bos taurus) (13)
   3. Rat (Rattus rattus) (1)
   4. Chicken (Gallus gallus) (1)
      mutant with a two residue deletion in the central helix
   5. African frog (Xenopus laevis) (8)
   6. Drosophila melanogaster (3)
   7. Ciliate (Paramecium tetraurelia) (3)
6. Myosin Essential Chain
   1. Bay scallop (Aequipecten irradians) (5)
   2. Chicken (Gallus gallus) (3)
7. Myosin Regulatory Chain
   1. Bay scallop (Aequipecten irradians) (5)
   2. Chicken (Gallus gallus) (1)
8. Calcineurin regulatory subunit (B-chain)
   1. Cow (Bos taurus) (1)
   2. Human (Homo sapiens) (1)
9. Recoverin
   Calcium-myristoyl switch; only one EF-hand is functional
   1. Cow (Bos taurus) (3)
10. Frequenin
    1. Baker's yeast (Saccharomyces cerevisiae) (1)
11. Guanylate cyclase activating protein 2, GCAP-2
    1. Cow (Bos taurus) (1)
12. Neurocalcin
    1. Cow (Bos taurus) (1)
13. Calium- and integrin-binding protein, CIB
    1. Human (Homo sapiens) (2)