Family: S100 proteins

dimer: subunits are made of two EF-hands

Lineage:

1. Root: scop
2. Class: All alpha proteins
3. Fold: EF Hand-like
   core: 4 helices; array of 2 hairpins, opened
4. Superfamily: EF-hand
   Duplication: consists of two EF-hand units: each is made of two helices connected with calcium-binding loop
5. Family: S100 proteins
   dimer: subunits are made of two EF-hands

Protein Domains:

1. Calcyclin (S100)
   1. Rabbit (Oryctolagus cuniculus) (3)
   2. Rat (Rattus norvegicus), s100b (4)
   3. Cow (Bos taurus), s100b (2)
   4. Human (Homo sapiens), s100b (1)
   5. Human (Homo sapiens), P11 s100a10, calpactin (2)
      ligand of annexin II
   6. Human (Homo sapiens), psoriasin s100a7 (3)
   7. Pig (Sus scrofa), calgizzarin s100c (s100a11) (1)
   8. Human (Homo sapiens), calgranulin s100a8, MRP8 (1)
      Migration inhibitory factor-related protein 8
   9. Human (Homo sapiens), calgranulin C, s100a12 (1)